4.6 Article

Modified FOLFIRINOX versus gemcitabine plus oxaliplatin as first-line chemotherapy for patients with locally advanced or metastatic cholangiocarcinoma: a retrospective comparative study

Journal

BMC CANCER
Volume 21, Issue 1, Pages -

Publisher

BMC
DOI: 10.1186/s12885-021-08549-2

Keywords

mFOLFIRINOX chemotherapy gemcitabine cholangiocarcinoma

Categories

Funding

  1. National Natural Science Foundation of China [82073206, 81773043, 81702315]
  2. Shuguang Program of Shanghai Education Development Foundation
  3. Shanghai Municipal Education Commission [20SG14]
  4. Program of Shanghai Academic Research Leader [19XD1422700]
  5. Emerging Frontier Program of Hospital Development Center [SHDC12018107]
  6. Clinical Science and Technology Innovation Project of Shanghai Shenkang Hospital Development Center [SHDC12019110]
  7. Basic Research Project of Science and Technology Commission of Shanghai Municipality [20JC1419100, 20JC1419101, 20JC1419102]
  8. Shanghai Sailing Program [21YF1428700]
  9. Peak Plateau Discipline Construction Project of Shanghai Jiaotong University School of medicine [20181808]

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For patients with advanced or metastatic CCA, first-line mFOLFIRINOX showed more promising results compared to Gemox, with higher disease control rate and longer progression-free survival.
BackgroundGemcitabine plus platinum as the first-line chemotherapy for cholangiocarcinoma (CCA) has limited efficacy. The aim of this study was to evaluate the effectiveness of modified FOLFIRINOX (mFOLFIRINOX) compared to that of gemcitabine plus oxaliplatin (Gemox) for patients with locally advanced or metastatic CCA.MethodsFrom January 2016 to December 2019, consecutive patients who were diagnosed with locally advanced or metastatic CCA were treated with either mFOLFIRINOX or Gemox as a first-line chemotherapy. The main endpoint was Progression free survival (PFS). The second endpoints were Overall survival (OS), Disease control rate (DCR) and incidence of severe toxicity (grade 3-4). Tumors were evaluated at baseline and thence every 4-6weeks. The study was designed and carried out in accordance with the principles of the declaration of Helsinki, approved by the Ethics Committee of Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine (XHEC-D-2020-154) and registered with ClinicalTrials.gov, number NCT04305288 (registration date: 12/03/2020).ResultsOf 49 patients in this study, 27 were in the FOLFIRINOX regimen group and 22 in the Gemox regimen group. There were no significant differences between groups in baseline characteristics. The DCR was 77.8% in the mFOLFIRINOX group and 63.5% in the Gemox group. The corresponding median PFS was 9.9months (95% confidence interval [CI], 7.3-12.4) in the mFOLFIRINOX group versus 6.4months (95% CI,3.6-9.2, p=0.040) in the Gemox group. The corresponding median OS was 15.7months (95% CI, 12.5-19.0) versus 12.0months (95% CI, 9.3-14.8, p=0.099). Significantly more grade 3-4 vomiting occurred in the mFOLFIRINOX than the Gemox groups (7 (25.9%) vs 1 (4.5%), p=0.044).ConclusionsFirst-line mFOLFIRINOX offered more promising results in patients with advanced or metastatic CCA.

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