VISPR-online: a web-based interactive tool to visualize CRISPR screening experiments

Background: VISPR is an interactive visualization and analysis framework for CRISPR screening experiments. However, it only supports the output of MAGeCK, and requires installation and manual configuration. Furthermore, VISPR is designed to run on a single computer, and data sharing between collaborators is challenging. Results: To make the tool easily accessible to the community, we present VISPRonline, a web-based general application allowing users to visualize, explore, and share CRISPR screening data online with a few simple steps. VISPR-online provides an exploration of screening results and visualization of read count changes. Apart from MAGeCK, VISPR-online supports two more popular CRISPR screening analysis tools: BAGEL and JACKS. It provides an interactive environment for exploring gene essentiality, viewing guide RNA (gRNA) locations, and allowing users to resume and share screening results. Conclusions: VISPR-online allows users to visualize, explore and share CRISPR screening data online.

Automated summary

VISPR-online is a web-based tool that allows users to visualize, explore, and share CRISPR screening data online. In addition to supporting MAGeCK, it also supports two other popular CRISPR screening analysis tools: BAGEL and JACKS.