4.5 Review

Cell therapy of chronic lymphocytic leukaemia: Transplants and chimeric antigen receptor (CAR)-T cells

Related references

Note: Only part of the references are listed.
Article Oncology

Ibrutinib for improved chimeric antigen receptor T-cell production for chronic lymphocytic leukemia patients

Fuli Fan et al.

Summary: The use of ibrutinib has been shown to improve the viability and expansion of CART cells derived from CLL patients, enriching them with less-differentiated naive-like T cell subsets and reducing exhaustion marker expression. Additionally, ibrutinib enhances the cytokine release capacity of CLL patient-derived CART cells, suggesting it can improve the yield and function of these cell products.

INTERNATIONAL JOURNAL OF CANCER (2021)

Article Hematology

Factors associated with outcomes after a second CD19-targeted CAR T-cell infusion for refractory B-cell malignancies

Jordan Gauthier et al.

Summary: CD19 CAR T-cell therapy has shown significant efficacy for R/R B-cell malignancies, but durable responses are limited. Second infusions of CD19 CAR T cells (CART2) can improve outcomes, with positive therapeutic effects observed in CLL, NHL, and ALL patients after CART2.

BLOOD (2021)

Editorial Material Hematology

Chronic lymphocytic leukemia prognostic models in real life: still a long way off

Stefano Molica

EXPERT REVIEW OF HEMATOLOGY (2021)

Review Immunology

T Cells in Chronic Lymphocytic Leukemia: A Two-Edged Sword

Elisavet Vlachonikola et al.

Summary: Chronic lymphocytic leukemia remains incurable despite recent progress in management, highlighting the importance of further investigating the underlying pathophysiology. The interactions between malignant CLL cells and the tumor microenvironment play a crucial role in disease progression, with T cell abnormalities and potential therapeutic targets being a key focus in enhancing targeted cytotoxic activity against the malignant clone.

FRONTIERS IN IMMUNOLOGY (2021)

Article Biophysics

Ibrutinib as a salvage therapy after allogeneic HCT for chronic lymphocytic leukemia

Mauricette Michallet et al.

BONE MARROW TRANSPLANTATION (2020)

Review Biochemistry & Molecular Biology

Harnessing the Effects of BTKi on T Cells for Effective Immunotherapy against CLL

Maissa Mhibik et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Oncology

Novel Therapies in Chronic Lymphocytic Leukemia: A Rapidly Changing Landscape

Lorenzo Iovino et al.

CURRENT TREATMENT OPTIONS IN ONCOLOGY (2020)

Article Oncology

Chronic lymphocytic leukemia in 2020: a surfeit of riches?

Sameer A. Parikh et al.

LEUKEMIA (2020)

Article Oncology

Long-Term Follow-Up of Anti-CD19 Chimeric Antigen Receptor T-Cell Therapy

Kathryn M. Cappell et al.

JOURNAL OF CLINICAL ONCOLOGY (2020)

Review Hematology

Chronic lymphocytic leukaemia: the role of T cells in a B cell disease

Stephen Man et al.

BRITISH JOURNAL OF HAEMATOLOGY (2019)

Article Medicine, General & Internal

Ibrutinib-Rituximab or Chemoimmunotherapy for Chronic Lymphocytic Leukemia

T. D. Shanafelt et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Article Medicine, General & Internal

Tisagenlecleucel in Adult Relapsed or Refractory Diffuse Large B-Cell Lymphoma

Stephen J. Schuster et al.

NEW ENGLAND JOURNAL OF MEDICINE (2019)

Letter Biophysics

Is there expert consensus on expert consensus?

Giovanni Barosi et al.

BONE MARROW TRANSPLANTATION (2018)

Article Oncology

Chronic lymphocytic leukemia cells acquire regulatory B-cell properties in response to TLR9 and CD40 activation

Shimrit Ringelstein-Harlev et al.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2018)

Article Medicine, General & Internal

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

S. L. Maude et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, General & Internal

Ibrutinib Regimens versus Chemoimmunotherapy in Older Patients with Untreated CLL

J. A. Woyach et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Article Medicine, Research & Experimental

Ibrutinib treatment improves T cell number and function in CLL patients

Meixiao Long et al.

JOURNAL OF CLINICAL INVESTIGATION (2017)

Article Medicine, General & Internal

Axicabtagene Ciloleucel CAR T-Cell Therapy in Refractory Large B-Cell Lymphoma

S. S. Neelapu et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Editorial Material Oncology

T cells in chronic lymphocytic leukemia: can they fight?

Anna Vardi et al.

ONCOTARGET (2017)

Review Pharmacology & Pharmacy

Ibrutinib-A double-edge sword in cancer and autoimmune disorders

Parviz Kokhaei et al.

JOURNAL OF DRUG TARGETING (2016)

Article Biophysics

Is there really a specific graft-versus-leukaemia effect?

R. P. Gale et al.

BONE MARROW TRANSPLANTATION (2016)

Article Multidisciplinary Sciences

Therapeutic antitumor immunity by checkpoint blockade is enhanced by ibrutinib, an inhibitor of both BTK and ITK

Idit Sagiv-Barfi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Medicine, General & Internal

Ibrutinib versus Ofatumumab in Previously Treated Chronic Lymphoid Leukemia

J. C. Byrd et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Editorial Material Biophysics

Markov model of CLL transplants

R. P. Gale

BONE MARROW TRANSPLANTATION (2012)

Review Hematology

Chronic lymphocytic leukemia and autoimmunity: a systematic review

Kate Hodgson et al.

HAEMATOLOGICA-THE HEMATOLOGY JOURNAL (2011)

Article Medicine, General & Internal

Chimeric Antigen Receptor-Modified T Cells in Chronic Lymphoid Leukemia

David L. Porter et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Review Oncology

T-cell function in chronic lymphocytic leukaemia

John C. Riches et al.

SEMINARS IN CANCER BIOLOGY (2010)

Review Biophysics

Graft-versus-leukemia in chronic lymphocytic leukemia

I. Ben-Bassat et al.

BONE MARROW TRANSPLANTATION (2007)