Live or die: PD-L1 delays neutrophil apoptosis Comment

Review Immunology

Neutrophils: Many Ways to Die

Erandi Perez-Figueroa et al.

Summary: Neutrophils play a crucial role in innate immune response by executing various effector functions. When activated, they undergo cell death processes to ensure the proper elimination of pathogens and damaged cells, contributing to timely resolution of inflammation. Neutrophils' cell death mechanisms include apoptosis, pyroptosis, necrosis, and others, ultimately maintaining homeostasis in the organism.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Multidisciplinary Sciences

PD-L1+ neutrophils contribute to injury-induced infection susceptibility

Ajitha Thanabalasuriar et al.

Summary: The rapid increase in neutrophil numbers in the lungs following injury is associated with elevated levels of PD-L1. Neutrophils transiently arrest in the lung vasculature and interact with PD-1 on lung endothelial cells, contributing to infection susceptibility. Treatment with an anti-PD-L1 antibody prevents neutrophil accumulation in the lung, reduces susceptibility to infection, and promotes skin healing.

SCIENCE ADVANCES (2021)

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Article Hematology

Upregulated PD-L1 delays human neutrophil apoptosis and promotes lung injury in an experimental mouse model of sepsis

Jia-feng Wang et al.

Summary: The study reveals that increased PD-L1 expression delays apoptosis in neutrophils from septic patients, triggering PI3K-dependent AKT phosphorylation to drive lung injury and increase mortality.

BLOOD (2021)

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Review Immunology