Journal
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
Volume 128, Issue 13, Pages 2141-2149Publisher
WILEY
DOI: 10.1111/1471-0528.16780
Keywords
Antenatal depression; perinatal depression; postpartum depression; patient and public involvement
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The study aimed to develop a Core Outcome Set for the treatment of perinatal depression through a systematic literature review and consensus development study, resulting in a COS of nine outcomes. This COS is expected to improve the consistency and uniformity of outcome selection and reporting in future clinical trials.
Objective To develop a Core Outcome Set (COS) for treatment of perinatal depression. Design Systematic overview of outcomes reported in the literature and consensus development study. Setting International. Population Two hundred and twenty-two participants, mainly patients, healthcare professionals and researchers, representing 13 countries. Methods A systematic overview of outcomes reported in recently published research, a two-round Delphi survey and a consensus meeting at which the final COS was decided using modified nominal group technique. Main results In the literature search, 1772 abstracts were identified and evaluated, and 165 studies were finally included in the review. In all, 106 outcomes were identified and included in the Delphi survey. In all, 222 participants registered for the first round of the Delphi survey and 151 (68%) responded. In the second round, 123 (55%) participants responded. Thirteen participants attended the consensus meeting, where the following nine outcomes were agreed upon for inclusion in the final COS: self-assessed symptoms of depression, diagnosis of depression by a clinician, parent to infant bonding, self-assessed symptoms of anxiety, quality of life, satisfaction with intervention, suicidal thoughts, attempted or committed suicide, thoughts of harming the baby, and adverse events. Conclusions The relevant stakeholders prioritised outcomes and reached consensus on a COS comprising nine outcomes. We expect that this COS will contribute to the consistency and uniformity of outcome selection and reporting in future clinical trials involving treatment of perinatal depression. Tweetable abstract Development of a core outcome set regarding treatment for perinatal depression by @SBU_en. Tweetable abstract
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