Journal
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
Volume 69, Issue 5, Pages 1893-1908Publisher
WILEY
DOI: 10.1002/bab.2255
Keywords
colorectal cancer; microRNAs; signaling pathways
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Colorectal cancer (CRC) is a major cause of cancer-related mortality and morbidity worldwide. Aberrant transcription of microRNAs (miRNAs) plays a significant role in the development of CRC, affecting prognosis, diagnosis, and treatment outcomes. MiRNAs are involved in various signaling pathways, primarily p53, EGFR, Wnt, and TGF-beta pathways.
Colorectal cancer (CRC) accounts for one of the main cancer-related mortality and morbidity worldwide. The molecular mechanisms of CRC development have been broadly investigated and, over the last decade, it has become evident that aberrant transcription of microRNAs (miRNAs), a class of small, noncoding RNA molecules, has a significant role in the inception and promotion of CRC. In the involved tissues of CRC, the transcription profile of miRNAs is modulated, and their expression templates are related with prognosis, diagnosis, and treatment outcomes. Here, in the current review, we attempted to discuss the latest information regarding the aberrantly expressed miRNAs in CRC and the advantages of utilizing miRNAs as biomarkers for early diagnosis and prognosis of CRC as well as potential therapeutic application. The effect of miRNAs involved in various signaling pathways, primarily p53, EGFR, Wnt, and TGF-beta pathways, was clarified.
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