Journal
EXPERIMENTAL GERONTOLOGY
Volume 77, Issue -, Pages 76-86Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exger.2016.02.017
Keywords
Pogostone; Photoaging; Ultraviolet; Antioxidant; Anti-inflammation; Matrix metalloproteinases
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Funding
- Hongkong, Macao and Taiwan Science & Technology Cooperation Program of China [2014 DFH30010]
- Guangdong International Cooperation Project [2013508102016]
- Science and Technology Planning Project of Guangdong Province, China [2013B090600007]
- Natural Science Foundation of Guangdong Province, China [2014A020221050]
- China Postdoctoral Science Foundation [2014M552188, 2015T80901]
- Guangdong Province Universities and Colleges Pearl River Scholar Scheme
- National Natural Science Foundation of China [81503318]
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Pogostone, a chemical constituent of patchouli oil, has been confirmed to possess favorable anti-inflammatory property. In the present study, we investigated the possible anti-photoaging potential of pogostone and the underlying mechanism against UV-induced skin damage in mice. The macroscopic and histopathological lesions were significantly ameliorated by pretreatment of pogostone as compared to the VC group. Furthermore, topical application of pogostone markedly increased the activities of the antioxidant enzymes, including catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and observably decreased malonaldehyde (MDA) level. Analysis of inflammatory cytokines showed obvious down-regulation of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta) and cyclooxygenase-2 (COX-2), prostaglandin E-2 (PGE2) in the pogostone groups. In addition, pogostone pretreatment evidently inhibited the abnormal expression of matrix metalloproteinases (MMP-1 and MMP-3). Taken together, pogostone exhibited prominent photo-protective activity mainly by its antioxidative and anti-inflammatory properties, promising it as an effective alternative pharmaceutical therapy for photoaging. (C) 2016 Elsevier Inc. All rights reserved.
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