4.6 Review

Modelling the functional genomics of Parkinson's disease in Caenorhabditis elegans: LRRK2 and beyond

Related references

Note: Only part of the references are listed.
Article Cell Biology

Retromer regulates the lysosomal clearance of MAPT/tau

Julian M. Carosi et al.

Summary: The autophagy-lysosome axis is crucial for the clearance of MAPT aggregates, with dysfunction of the central retromer component VPS35 leading to impaired autophagic resolution and accumulation of cytoplasmic MAPT aggregates. Maintaining the integrity of the retromer complex regulates the autophagy-lysosome axis to suppress MAPT aggregation and propagation.

AUTOPHAGY (2021)

Article Neurosciences

Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1

Shruti Sharma et al.

Summary: WDL has the potential to alleviate parkinsonism in Caenorhabditis elegans by reducing alpha-synuclein levels, improving neuronal health, and increasing dopamine levels. It also enhances mitochondrial health, decreases lipid and triglyceride levels, and alleviates protein carbonyl levels in PD conditions. These findings suggest that WDL could be a promising candidate for combating age-related multi-factorial PD pathology.

MOLECULAR NEUROBIOLOGY (2021)

Article Biochemistry & Molecular Biology

Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms

Asad U. Malik et al.

Summary: Autosomal dominant mutations in LRRK2 enhance kinase activity and cause Parkinson's disease. LRRK2 phosphorylates Rab GTPases including Rab8A and Rab10. This study found that LRRK1 can phosphorylate Rab7A at Ser72, and identified mutations that enhance this phosphorylation.

BIOCHEMICAL JOURNAL (2021)

Article Clinical Neurology

Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study

Edwin Jabbari et al.

Summary: The study identified genetic variation at the LRRK2 locus associated with survival in PSP patients. The mechanism of this association may involve lncRNA-regulated effects on LRRK2 expression. Further functional studies are needed to explore the potential of modulating LRRK2 as a therapy for PSP and related tauopathies.

LANCET NEUROLOGY (2021)

Article Biochemistry & Molecular Biology

Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes

C. Alexander Boecker et al.

Summary: Mutations in the LRRK2 gene associated with Parkinson's disease lead to defects in autophagosome transport, impairing effective degradation of autophagosomal cargo in neurons.

CURRENT BIOLOGY (2021)

Article Genetics & Heredity

A novel homozygous LRRK1 stop gain mutation in a patient suspected with osteosclerotic metaphyseal dysplasia

Mohammad Miryounesi et al.

ANNALS OF HUMAN GENETICS (2020)

Review Clinical Neurology

The genetic architecture of Parkinson's disease

Cornelis Blauwendraat et al.

LANCET NEUROLOGY (2020)

Review Biochemistry & Molecular Biology

Leucine-rich repeat kinase 2 and lysosomal dyshomeostasis in Parkinson disease

Susanna Cogo et al.

JOURNAL OF NEUROCHEMISTRY (2020)

Review Clinical Neurology

LRRK2 in Parkinson disease: challenges of clinical trials

Eduardo Tolosa et al.

NATURE REVIEWS NEUROLOGY (2020)

Article Multidisciplinary Sciences

In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets

Scott C. Vermilyea et al.

SCIENTIFIC REPORTS (2020)

Article Clinical Neurology

Characterization of Recessive Parkinson Disease in a Large Multicenter Study

Suzanne Lesage et al.

ANNALS OF NEUROLOGY (2020)

Review Biochemistry & Molecular Biology

Historical Perspective: Models of Parkinson's Disease

Shyh Jenn Chia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Genetics & Heredity

Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan

Yuanzhe Li et al.

JOURNAL OF HUMAN GENETICS (2020)

Review Neurosciences

Guilt-by-Association - Functional Insights Gained From Studying the LRRK2 Interactome

Christian Johannes Gloeckner et al.

FRONTIERS IN NEUROSCIENCE (2020)

Article Biochemistry & Molecular Biology

The effect of LRRK2 loss-of-function variants in humans

Nicola Whiffin et al.

NATURE MEDICINE (2020)

Article Cell Biology

PINOT: an intuitive resource for integrating protein-protein interactions

James E. Tomkins et al.

CELL COMMUNICATION AND SIGNALING (2020)

Review Neurosciences

LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models

Dylan J. Dues et al.

FRONTIERS IN NEUROSCIENCE (2020)

Review Neurosciences

Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics

Kaela Kelly et al.

FRONTIERS IN NEUROSCIENCE (2020)

Article Multidisciplinary Sciences

Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity

An Phu Tran Nguyen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Multidisciplinary Sciences

LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication

Keisuke Onishi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Article Clinical Neurology

The Parkinson's DiseaseGenome-WideAssociation Study Locus Browser

Francis P. Grenn et al.

MOVEMENT DISORDERS (2020)

Review Neurosciences

LRRK2 and the Endolysosomal System in Parkinson's Disease

Madalynn L. Erb et al.

JOURNAL OF PARKINSONS DISEASE (2020)

Review Neurosciences

The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease

Hardy J. Rideout et al.

FRONTIERS IN NEUROSCIENCE (2020)

Article Medicine, Research & Experimental

Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

Joanna A. Korecka et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2020)

Review Biochemistry & Molecular Biology

C. elegans Models to Study the Propagation of Prions and Prion-Like Proteins

Carl Alexander Sandhof et al.

BIOMOLECULES (2020)

Article Biochemistry & Molecular Biology

Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity

Alexia F. Kalogeropulou et al.

BIOCHEMICAL JOURNAL (2020)

Article Cell Biology

Modeling neurodegeneration in Caenorhabditis elegans

Kim A. Caldwell et al.

DISEASE MODELS & MECHANISMS (2020)

Article Cell Biology

Inhibition of mitophagy decreases survival of Caenorhabditis elegans by increasing protein aggregation

Mehtap Civelek et al.

MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)

Review Biochemistry & Molecular Biology

LRRK2 links genetic and sporadic Parkinson's disease

Jillian H. Kluss et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2019)

Article Clinical Neurology

The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease

Sara Bandres-Ciga et al.

MOVEMENT DISORDERS (2019)

Article Multidisciplinary Sciences

Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration

Xi Chen et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Chemistry, Medicinal

LRRK2 in Infection: Friend or Foe?

Susanne Herbst et al.

ACS INFECTIOUS DISEASES (2019)

Article Clinical Neurology

LRRK2 modifies α-syn pathology and spread in mouse models and human neurons

Gregor Bieri et al.

ACTA NEUROPATHOLOGICA (2019)

Article Neurosciences

Leucine rich repeat kinase 2: a paradigm for pleiotropy

Patrick A. Lewis

JOURNAL OF PHYSIOLOGY-LONDON (2019)

Review Biochemistry & Molecular Biology

Role of the endolysosomal system in Parkinson's disease

D. J. Vidyadhara et al.

JOURNAL OF NEUROCHEMISTRY (2019)

Article Multidisciplinary Sciences

Whole-animal connectomes of both Caenorhabditis elegans sexes

Steven J. Cook et al.

NATURE (2019)

Review Biochemistry & Molecular Biology

Progress in the genetic analysis of Parkinson's disease

Andrew Singleton et al.

HUMAN MOLECULAR GENETICS (2019)

Review Clinical Neurology

Neuropathology of dementia in patients with Parkinson's disease: a systematic review of autopsy studies

Callum . Smith et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)

Article Neurosciences

Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease

Michael X. Henderson et al.

ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2

Xiaorong Huang et al.

FASEB JOURNAL (2019)

Article Biochemistry & Molecular Biology

Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport

Victoria J. Butler et al.

HUMAN MOLECULAR GENETICS (2019)

Review Biochemistry & Molecular Biology

Roco Proteins: GTPases with a Baroque Structure and Mechanism

Lina Wauters et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Biochemistry & Molecular Biology

Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2

Rebekah G. Langston et al.

NEUROCHEMICAL RESEARCH (2019)

Article Multidisciplinary Sciences

Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking

Dieter Waschbuesch et al.

PLOS ONE (2019)

Review Neurosciences

LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same

Daniel C. Berwick et al.

MOLECULAR NEURODEGENERATION (2019)

Article Biochemistry & Molecular Biology

G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain

An Phu Tran Nguyen et al.

HUMAN MOLECULAR GENETICS (2018)

Article Biochemistry & Molecular Biology

Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology

Tetta Fujimoto et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)

Article Clinical Neurology

Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains

Michael J. Keogh et al.

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)

Review Neurosciences

Modeling Parkinson's Disease in C. elegans

Jason F. Cooper et al.

JOURNAL OF PARKINSONS DISEASE (2018)

Article Clinical Neurology

A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease

Lasse Pihlstrom et al.

ANNALS OF NEUROLOGY (2018)

Review Clinical Neurology

C9orf72-mediated ALS and FTD: multiple pathways to disease

Rubika Balendra et al.

NATURE REVIEWS NEUROLOGY (2018)

Article Multidisciplinary Sciences

LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

Tomoya Eguchi et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Article Cell Biology

LRRK2 activation in idiopathic Parkinson's disease

Roberto Di Maio et al.

SCIENCE TRANSLATIONAL MEDICINE (2018)

Article Multidisciplinary Sciences

LRRK2 kinase regulates alpha-synuclein propagation via RAB35 phosphorylation

Eun-Jin Bae et al.

NATURE COMMUNICATIONS (2018)

Article Infectious Diseases

Prediction of leprosy in the Chinese population based on a weighted genetic risk score

Na Wang et al.

PLOS NEGLECTED TROPICAL DISEASES (2018)

Article Clinical Neurology

Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease

Cornelis Blauwendraat et al.

JAMA NEUROLOGY (2018)

Article Genetics & Heredity

ClinVar at five years: Delivering on the promise

Melissa J. Landrum et al.

HUMAN MUTATION (2018)

Article Neurosciences

RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A

Jesus Madero-Perez et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Review Clinical Neurology

Tau Pathology in Parkinson's Disease

Xue Zhang et al.

FRONTIERS IN NEUROLOGY (2018)

Article Biochemistry & Molecular Biology

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase

Elena Purlyte et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2

Marian Blanca Ramirez et al.

HUMAN MOLECULAR GENETICS (2017)

Article Immunology

Rab32 connects ER stress to mitochondrial defects in multiple sclerosis

Yohannes Haile et al.

JOURNAL OF NEUROINFLAMMATION (2017)

Article Neurosciences

α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling

Audrey T. Medeiros et al.

FRONTIERS IN CELLULAR NEUROSCIENCE (2017)

Review Neurosciences

The Synucleinopathies: Twenty Years On

Michel Goedert et al.

JOURNAL OF PARKINSONS DISEASE (2017)

Review Neurosciences

VPS35, the Retromer Complex and Parkinson's Disease

Erin T. Williams et al.

JOURNAL OF PARKINSONS DISEASE (2017)

Review Neurosciences

The Role of Co-chaperones in Synaptic Proteostasis and Neurodegenerative Disease

Erica L. Gorenberg et al.

FRONTIERS IN NEUROSCIENCE (2017)

Article Medicine, Research & Experimental

LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model

Hien Tran Zhao et al.

MOLECULAR THERAPY-NUCLEIC ACIDS (2017)

Article Genetics & Heredity

Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models

Malabika Maulik et al.

Frontiers in Genetics (2017)

Review Neurosciences

Nicotine from cigarette smoking and diet and Parkinson disease: a review

Chaoran Ma et al.

TRANSLATIONAL NEURODEGENERATION (2017)

Article Multidisciplinary Sciences

Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein

Trevor Tyson et al.

SCIENTIFIC REPORTS (2017)

Article Multidisciplinary Sciences

Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes

Kushal Sejwal et al.

SCIENTIFIC REPORTS (2017)

Review Biochemistry & Molecular Biology

Genetic and Pharmacological Discovery for Alzheimer's Disease Using Caenorhabditis elegans

Edward F. Griffin et al.

ACS CHEMICAL NEUROSCIENCE (2017)

Review Clinical Neurology

New Genes Causing Hereditary Parkinson's Disease or Parkinsonism

Andreas Puschmann

CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2017)

Article Neurosciences

LRRK2 levels in immune cells are increased in Parkinson'sdisease

D. A. Cook et al.

NPJ PARKINSONS DISEASE (2017)

Article Neurosciences

LRRK2 Promotes Tau Accumulation, Aggregation and Release

Patricia Silva Guerreiro et al.

MOLECULAR NEUROBIOLOGY (2016)

Article Clinical Neurology

DNAJC6 Mutations Associated With Early-Onset Parkinson's Disease

Simone Olgiati et al.

ANNALS OF NEUROLOGY (2016)

Review Genetics & Heredity

CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering

Daniel J. Dickinson et al.

GENETICS (2016)

Article Biochemistry & Molecular Biology

A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death

Tomas Lopes da Fonseca et al.

HUMAN MOLECULAR GENETICS (2016)

Review Biochemistry & Molecular Biology

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

Dena G. Hernandez et al.

JOURNAL OF NEUROCHEMISTRY (2016)

Review Clinical Neurology

Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies

Maria Xilouri et al.

MOVEMENT DISORDERS (2016)

Article Multidisciplinary Sciences

Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts

Giambattista Guaitoli et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)

Article Biochemical Research Methods

The C. elegans Connectome Consists of Homogenous Circuits with Defined Functional Roles

Aharon Azulay et al.

PLOS COMPUTATIONAL BIOLOGY (2016)

Article Multidisciplinary Sciences

Premotor Symptoms as Predictors of Outcome in Parkinsons Disease: A Case-Control Study

Yu-Hsuan Wu et al.

PLOS ONE (2016)

Article Multidisciplinary Sciences

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

Tomoki Kuwahara et al.

SCIENTIFIC REPORTS (2016)

Article Biochemistry & Molecular Biology

Widespread Proteome Remodeling and Aggregation in Aging C-elegans

Dirk M. Walther et al.

Article Biochemistry & Molecular Biology

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

Joao P. L. Daher et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Clinical Neurology

Prediagnostic presentations of Parkinson's disease in primary care: a case-control study

Anette Schrag et al.

LANCET NEUROLOGY (2015)

Article Biochemistry & Molecular Biology

Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C-elegans

Sudipta Chakraborty et al.

METALLOMICS (2015)

Review Biochemistry & Molecular Biology

Detecting balancing selection in genomes: limits and prospects

Anna Fijarczyk et al.

MOLECULAR ECOLOGY (2015)

Editorial Material Clinical Neurology

VPS35 and EIF4G1 Interactions and Novel Candidate Genes for PD: From Genes to Pathways and Back

Roberto Erro

MOVEMENT DISORDERS (2015)

Review Clinical Neurology

MDS clinical diagnostic criteria for Parkinson's disease

Ronald B. Postuma et al.

MOVEMENT DISORDERS (2015)

Article Geriatrics & Gerontology

Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage

Tomoharu Kuboyama et al.

NEUROBIOLOGY OF AGING (2015)

Article Multidisciplinary Sciences

Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism

Stanley B. Prusiner et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)

Article Cell Biology

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

Reina N. Fuji et al.

SCIENCE TRANSLATIONAL MEDICINE (2015)

Article Genetics & Heredity

Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with α-Synuclein Pathology

Gabrielle R. Wilson et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2014)

Article Biochemistry & Molecular Biology

DNAJC13 mutations in Parkinson disease

Carles Vilarino-Gueell et al.

HUMAN MOLECULAR GENETICS (2014)

Article Biochemistry & Molecular Biology

Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration

Elpida Tsika et al.

HUMAN MOLECULAR GENETICS (2014)

Article Biochemistry & Molecular Biology

Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction

Eric S. Luth et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2014)

Article Clinical Neurology

VPS35 Parkinson's disease phenotype resembles the sporadic disease

Walter Struhal et al.

JOURNAL OF NEURAL TRANSMISSION (2014)

Article Biochemistry & Molecular Biology

Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct celluar signaling pathways

Lauran Reyniers et al.

JOURNAL OF NEUROCHEMISTRY (2014)

Article Clinical Neurology

Frontotemporal dementia and its subtypes: a genome-wide association study

Raffaele Ferrari et al.

LANCET NEUROLOGY (2014)

Article Multidisciplinary Sciences

Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats

Joao P. L. Daher et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Multidisciplinary Sciences

Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease

Alexandria Beilina et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

Article Clinical Neurology

Alpha-synuclein biology in Lewy body diseases

Woojin Scott Kim et al.

ALZHEIMERS RESEARCH & THERAPY (2014)

Article Clinical Neurology

Disease Penetrance of Late-Onset Parkinsonism A Meta-analysis

Joanne Trinh et al.

JAMA NEUROLOGY (2014)

Article Biochemistry & Molecular Biology

The million mutation project: A new approach to genetics in Caenorhabditis elegans

Owen Thompson et al.

GENOME RESEARCH (2013)

Article Biochemistry & Molecular Biology

GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2

Alice Biosa et al.

HUMAN MOLECULAR GENETICS (2013)

Article Biochemistry & Molecular Biology

Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity

Chen Yao et al.

HUMAN MOLECULAR GENETICS (2013)

Article Cell Biology

PTL-1 regulates neuronal integrity and lifespan in C-elegans

Yee Lian Chew et al.

JOURNAL OF CELL SCIENCE (2013)

Article Neurosciences

Interplay of LRRK2 with chaperone-mediated autophagy

Samantha J. Orenstein et al.

NATURE NEUROSCIENCE (2013)

Article Biochemistry & Molecular Biology

Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimers diseases

Giovanni Coppola et al.

HUMAN MOLECULAR GENETICS (2012)

Article Cell Biology

RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway

Donglei Zhang et al.

JOURNAL OF CELL BIOLOGY (2012)

Article Medicine, General & Internal

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

Randall J. Bateman et al.

NEW ENGLAND JOURNAL OF MEDICINE (2012)

Review Clinical Neurology

α-synuclein, LRRK2 and their interplay in Parkinson's disease

Guoxiang Liu et al.

FUTURE NEUROLOGY (2012)

Article Genetics & Heredity

A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease

Alexander Zimprich et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)

Article Genetics & Heredity

VPS35 Mutations in Parkinson Disease

Carles Vilarino-Gueell et al.

AMERICAN JOURNAL OF HUMAN GENETICS (2011)

Article Genetics & Heredity

Replication of GWAS Associations for GAK and MAPT in Parkinson's Disease

Shannon L. Rhodes et al.

ANNALS OF HUMAN GENETICS (2011)

Article Biochemistry & Molecular Biology

Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2

Xianming Deng et al.

NATURE CHEMICAL BIOLOGY (2011)

Article Clinical Neurology

LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study

S. Sharma et al.

NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2011)

Article Biochemistry & Molecular Biology

Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1

Frits Kamp et al.

EMBO JOURNAL (2010)

Article Biochemistry & Molecular Biology

Genetic variability at the PARK16 locus

Arianna Tucci et al.

EUROPEAN JOURNAL OF HUMAN GENETICS (2010)

Article Biochemistry & Molecular Biology

Global microRNA Expression Profiling of Caenorhabditis elegans Parkinson's Disease Models

Suvi Asikainen et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2010)

Article Biochemistry & Molecular Biology

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

Byoung Dae Lee et al.

NATURE MEDICINE (2010)

Article Biochemistry & Molecular Biology

The R1441C mutation alters the folding properties of the ROC domain of LRRK2

Yongchao Li et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)

Article Cell Biology

The function of ROCO proteins in health and disease

Patrick A. Lewis

BIOLOGY OF THE CELL (2009)

Letter Cell Biology

DOG 1.0: illustrator of protein domain structures

Jian Ren et al.

CELL RESEARCH (2009)

Article Biochemistry & Molecular Biology

Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways

Rosa M. Sancho et al.

HUMAN MOLECULAR GENETICS (2009)

Article Biochemistry & Molecular Biology

Caenorhabditits elegans LRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth

Julia Saermann et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2009)

Article Neurosciences

LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans

Shamol Saha et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Medicine, General & Internal

Genomewide Association Study of Leprosy

Fu-Ren Zhang et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Review Clinical Neurology

Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria

Dennis W. Dickson et al.

LANCET NEUROLOGY (2009)

Article Cell Biology

C-elegans AP-2 and retromer control Wnt signaling by regulating MIG-14/Wntless

Chun-Liang Pan et al.

DEVELOPMENTAL CELL (2008)

Article Biochemistry & Molecular Biology

The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation

Elisa Greggio et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2008)

Article Biochemistry & Molecular Biology

Ancient origin of the Parkinson disease gene LRRK2

Ignacio Marin

JOURNAL OF MOLECULAR EVOLUTION (2008)

Article Clinical Neurology

Investigating convergent actions of genes linked to familial Parkinson's disease

Benjamin Wolozin et al.

NEURODEGENERATIVE DISEASES (2008)

Article Clinical Neurology

Autosomal dominant dopa-responsive parkinsonism in a multigenerational Swiss family

C. Wider et al.

PARKINSONISM & RELATED DISORDERS (2008)

Article Biochemistry & Molecular Biology

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Patrick A. Lewis et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)

Article Biochemistry & Molecular Biology

LRK-1, a C-elegans PARK8-Related kinase, regulates axonal-dendritic polarity of SV proteins

Aisa Sakaguchi-Nakashima et al.

CURRENT BIOLOGY (2007)

Article Biochemistry & Molecular Biology

Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity

Andrew B. West et al.

HUMAN MOLECULAR GENETICS (2007)

Article Biochemistry & Molecular Biology

The Parkinson disease gene LRRK2:: Evolutionary and structural insights

Ignacio Marin

MOLECULAR BIOLOGY AND EVOLUTION (2006)

Article Neurosciences

Mutations in DJ-1 are rare in familial Parkinson disease

Nathan Pankratz et al.

NEUROSCIENCE LETTERS (2006)

Article Neurosciences

Kinase activity of mutant LRRK2 mediates neuronal toxicity

Wanli W. Smith et al.

NATURE NEUROSCIENCE (2006)

Article Neurosciences

Kinase activity is required for the toxic effects of mutant LRRK2/dardarin

Elisa Greggio et al.

NEUROBIOLOGY OF DISEASE (2006)

Article Multidisciplinary Sciences

Wnt gradient formation requires retromer function in Wnt-producing cells

DYM Coudreuse et al.

SCIENCE (2006)

Article Biochemistry & Molecular Biology

The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity

CJ Gloeckner et al.

HUMAN MOLECULAR GENETICS (2006)

Article Biochemistry & Molecular Biology

Familial Parkinson mutant α-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans

T Kuwahara et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2006)

Article Clinical Neurology

Model-guided microarray implicates the retromer complex in Alzheimer's disease

SA Small et al.

ANNALS OF NEUROLOGY (2005)

Article Multidisciplinary Sciences

Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity

AB West et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Article Biochemistry & Molecular Biology

A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress

W Springer et al.

HUMAN MOLECULAR GENETICS (2005)

Article Cell Biology

Genetic analysis of lysosomal trafficking in Caenorhabditis elegans

GJ Hermann et al.

MOLECULAR BIOLOGY OF THE CELL (2005)

Article Biochemistry & Molecular Biology

Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α-synuclein

M Lakso et al.

JOURNAL OF NEUROCHEMISTRY (2003)

Review Geriatrics & Gerontology

Staging of brain pathology related to sporadic Parkinson's disease

H Braak et al.

NEUROBIOLOGY OF AGING (2003)

Article Multidisciplinary Sciences

Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

RS Kamath et al.

NATURE (2003)

Review Multidisciplinary Sciences

Signal transduction - The guanine nucleotide-binding switch in three dimensions

IR Vetter et al.

SCIENCE (2001)

Article Biochemistry & Molecular Biology

WormBase: network access to the genome and biology of Caenorhabditis elegans

L Stein et al.

NUCLEIC ACIDS RESEARCH (2001)