Related references
Note: Only part of the references are listed.Retromer regulates the lysosomal clearance of MAPT/tau
Julian M. Carosi et al.
AUTOPHAGY (2021)
Wedelolactone Mitigates Parkinsonism Via Alleviating Oxidative Stress and Mitochondrial Dysfunction Through NRF2/SKN-1
Shruti Sharma et al.
MOLECULAR NEUROBIOLOGY (2021)
Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms
Asad U. Malik et al.
BIOCHEMICAL JOURNAL (2021)
Genetic determinants of survival in progressive supranuclear palsy: a genome-wide association study
Edwin Jabbari et al.
LANCET NEUROLOGY (2021)
Increased LRRK2 kinase activity alters neuronal autophagy by disrupting the axonal transport of autophagosomes
C. Alexander Boecker et al.
CURRENT BIOLOGY (2021)
A novel homozygous LRRK1 stop gain mutation in a patient suspected with osteosclerotic metaphyseal dysplasia
Mohammad Miryounesi et al.
ANNALS OF HUMAN GENETICS (2020)
The genetic architecture of Parkinson's disease
Cornelis Blauwendraat et al.
LANCET NEUROLOGY (2020)
Leucine-rich repeat kinase 2 and lysosomal dyshomeostasis in Parkinson disease
Susanna Cogo et al.
JOURNAL OF NEUROCHEMISTRY (2020)
Parkinson's disease, aging and adult neurogenesis: Wnt/β-catenin signalling as the key to unlock the mystery of endogenous brain repair
Bianca Marchetti et al.
AGING CELL (2020)
Adult Osteosclerotic Metaphyseal Dysplasia With Progressive Osteonecrosis of the Jaws and Abnormal Bone Resorption Pattern Due to a LRRK1 Splice Site Mutation
Antonia Howaldt et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2020)
LRRK2 in Parkinson disease: challenges of clinical trials
Eduardo Tolosa et al.
NATURE REVIEWS NEUROLOGY (2020)
Dysregulated iron metabolism in C. elegans catp-6/ATP13A2 mutant impairs mitochondrial function
Nikhita Anand et al.
NEUROBIOLOGY OF DISEASE (2020)
In Vitro CRISPR/Cas9-Directed Gene Editing to Model LRRK2 G2019S Parkinson's Disease in Common Marmosets
Scott C. Vermilyea et al.
SCIENTIFIC REPORTS (2020)
Characterization of Recessive Parkinson Disease in a Large Multicenter Study
Suzanne Lesage et al.
ANNALS OF NEUROLOGY (2020)
Historical Perspective: Models of Parkinson's Disease
Shyh Jenn Chia et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)
Clinical characterization of patients with leucine-rich repeat kinase 2 genetic variants in Japan
Yuanzhe Li et al.
JOURNAL OF HUMAN GENETICS (2020)
The Parkinson's Disease Protein LRRK2 Interacts with the GARP Complex to Promote Retrograde Transport to the trans-Golgi Network
Alexandra Beilina et al.
CELL REPORTS (2020)
Guilt-by-Association - Functional Insights Gained From Studying the LRRK2 Interactome
Christian Johannes Gloeckner et al.
FRONTIERS IN NEUROSCIENCE (2020)
Genetic perspective on the synergistic connection between vesicular transport, lysosomal and mitochondrial pathways associated with Parkinson's disease pathogenesis
Stefanie Smolders et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
The effect of LRRK2 loss-of-function variants in humans
Nicola Whiffin et al.
NATURE MEDICINE (2020)
Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease
S. Bandres-Ciga et al.
ACTA NEUROPATHOLOGICA (2020)
PINOT: an intuitive resource for integrating protein-protein interactions
James E. Tomkins et al.
CELL COMMUNICATION AND SIGNALING (2020)
LRRK2 and Protein Aggregation in Parkinson's Disease: Insights From Animal Models
Dylan J. Dues et al.
FRONTIERS IN NEUROSCIENCE (2020)
Pharmacodynamic Biomarkers for Emerging LRRK2 Therapeutics
Kaela Kelly et al.
FRONTIERS IN NEUROSCIENCE (2020)
Sequential screening nominates the Parkinson's disease associated kinase LRRK2 as a regulator of Clathrin-mediated endocytosis
George R. Heaton et al.
NEUROBIOLOGY OF DISEASE (2020)
Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity
An Phu Tran Nguyen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
LRRK2 mediates axon development by regulating Frizzled3 phosphorylation and growth cone-growth cone communication
Keisuke Onishi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
The Parkinson's DiseaseGenome-WideAssociation Study Locus Browser
Francis P. Grenn et al.
MOVEMENT DISORDERS (2020)
LRRK2 and the Endolysosomal System in Parkinson's Disease
Madalynn L. Erb et al.
JOURNAL OF PARKINSONS DISEASE (2020)
The Current State-of-the Art of LRRK2-Based Biomarker Assay Development in Parkinson's Disease
Hardy J. Rideout et al.
FRONTIERS IN NEUROSCIENCE (2020)
Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice
Joanna A. Korecka et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2020)
C. elegans Models to Study the Propagation of Prions and Prion-Like Proteins
Carl Alexander Sandhof et al.
BIOMOLECULES (2020)
Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity
Alexia F. Kalogeropulou et al.
BIOCHEMICAL JOURNAL (2020)
(D620N) VPS35 causes the impairment of Wnt/β-catenin signaling cascade and mitochondrial dysfunction in a PARK17 knockin mouse model
Ching-Chi Chiu et al.
CELL DEATH & DISEASE (2020)
Modeling neurodegeneration in Caenorhabditis elegans
Kim A. Caldwell et al.
DISEASE MODELS & MECHANISMS (2020)
Inhibition of mitophagy decreases survival of Caenorhabditis elegans by increasing protein aggregation
Mehtap Civelek et al.
MOLECULAR AND CELLULAR BIOCHEMISTRY (2019)
LRRK2 links genetic and sporadic Parkinson's disease
Jillian H. Kluss et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2019)
Vitamin B12 modulates Parkinson's disease LRRK2 kinase activity through allosteric regulation and confers neuroprotection
Adam Schaffner et al.
CELL RESEARCH (2019)
The endocytic membrane trafficking pathway plays a major role in the risk of Parkinson's disease
Sara Bandres-Ciga et al.
MOVEMENT DISORDERS (2019)
Parkinson's disease-linked D620N VPS35 knockin mice manifest tau neuropathology and dopaminergic neurodegeneration
Xi Chen et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)
LRRK2 in Infection: Friend or Foe?
Susanne Herbst et al.
ACS INFECTIOUS DISEASES (2019)
LRRK2 modifies α-syn pathology and spread in mouse models and human neurons
Gregor Bieri et al.
ACTA NEUROPATHOLOGICA (2019)
Leucine rich repeat kinase 2: a paradigm for pleiotropy
Patrick A. Lewis
JOURNAL OF PHYSIOLOGY-LONDON (2019)
Anti-ageing and anti-Parkinsonian effects of natural flavonol, tambulin from Zanthoxyllum aramatum promotes longevity in Caenorhabditis elegans
Taruna Pandey et al.
EXPERIMENTAL GERONTOLOGY (2019)
Role of the endolysosomal system in Parkinson's disease
D. J. Vidyadhara et al.
JOURNAL OF NEUROCHEMISTRY (2019)
Whole-animal connectomes of both Caenorhabditis elegans sexes
Steven J. Cook et al.
NATURE (2019)
An integrated transcriptomics and proteomics analysis reveals functional endocytic dysregulation caused by mutations in LRRK2
Natalie Connor-Robson et al.
NEUROBIOLOGY OF DISEASE (2019)
Progress in the genetic analysis of Parkinson's disease
Andrew Singleton et al.
HUMAN MOLECULAR GENETICS (2019)
Neuropathology of dementia in patients with Parkinson's disease: a systematic review of autopsy studies
Callum . Smith et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2019)
Strengths and limitations of morphological and behavioral analyses in detecting dopaminergic deficiency in Caenorhabditis elegans
Latasha L. Smith et al.
NEUROTOXICOLOGY (2019)
Alzheimer's disease tau is a prominent pathology in LRRK2 Parkinson's disease
Michael X. Henderson et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2019)
The Parkinson's disease-associated mutation N1437H impairs conformational dynamics in the G domain of LRRK2
Xiaorong Huang et al.
FASEB JOURNAL (2019)
Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport
Victoria J. Butler et al.
HUMAN MOLECULAR GENETICS (2019)
Roco Proteins: GTPases with a Baroque Structure and Mechanism
Lina Wauters et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)
Differences in Stability, Activity and Mutation Effects Between Human and Mouse Leucine-Rich Repeat Kinase 2
Rebekah G. Langston et al.
NEUROCHEMICAL RESEARCH (2019)
Rab32 interacts with SNX6 and affects retromer-dependent Golgi trafficking
Dieter Waschbuesch et al.
PLOS ONE (2019)
Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies
Mike A. Nalls et al.
LANCET NEUROLOGY (2019)
LRRK2 Biology from structure to dysfunction: research progresses, but the themes remain the same
Daniel C. Berwick et al.
MOLECULAR NEURODEGENERATION (2019)
Found in Translation: The Utility of C. elegans Alpha-Synuclein Models of Parkinson's Disease
Anthony L. Gaeta et al.
BRAIN SCIENCES (2019)
G2019S LRRK2 enhances the neuronal transmission of tau in the mouse brain
An Phu Tran Nguyen et al.
HUMAN MOLECULAR GENETICS (2018)
LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network
Zhiyong Liu et al.
HUMAN MOLECULAR GENETICS (2018)
Parkinson's disease-associated mutant LRRK2 phosphorylates Rab7L1 and modifies trans-Golgi morphology
Tetta Fujimoto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2018)
The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human
Rafeeq Mir et al.
BIOCHEMICAL JOURNAL (2018)
Oligogenic genetic variation of neurodegenerative disease genes in 980 postmortem human brains
Michael J. Keogh et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2018)
Functional variants in the LRRK2 gene confer shared effects on risk for Crohn's disease and Parkinson's disease
Ken Y. Hui et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
Gene-by-environment interactions that disrupt mitochondrial homeostasis cause neurodegeneration in C. elegans Parkinson's models
Hanna Kim et al.
CELL DEATH & DISEASE (2018)
Modeling Parkinson's Disease in C. elegans
Jason F. Cooper et al.
JOURNAL OF PARKINSONS DISEASE (2018)
Imbalanced Expression of Tau and Tubulin Induces Neuronal Dysfunction in C. elegans Models of Tauopathy
Tomohiro Miyasaka et al.
FRONTIERS IN NEUROSCIENCE (2018)
A comprehensive analysis of SNCA-related genetic risk in sporadic parkinson disease
Lasse Pihlstrom et al.
ANNALS OF NEUROLOGY (2018)
Mutation of hop-1 and pink-1 attenuates vulnerability of neurotoxicity in C. elegans: the role of mitochondria-associated membrane proteins in Parkinsonism
Siyu Wu et al.
EXPERIMENTAL NEUROLOGY (2018)
α-synuclein expression from a single copy transgene increases sensitivity to stress and accelerates neuronal loss in genetic models of Parkinson's disease
Jason F. Cooper et al.
EXPERIMENTAL NEUROLOGY (2018)
C9orf72-mediated ALS and FTD: multiple pathways to disease
Rubika Balendra et al.
NATURE REVIEWS NEUROLOGY (2018)
LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis
Tomoya Eguchi et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)
LRRK2 activation in idiopathic Parkinson's disease
Roberto Di Maio et al.
SCIENCE TRANSLATIONAL MEDICINE (2018)
LRRK2 kinase regulates alpha-synuclein propagation via RAB35 phosphorylation
Eun-Jin Bae et al.
NATURE COMMUNICATIONS (2018)
Prediction of leprosy in the Chinese population based on a weighted genetic risk score
Na Wang et al.
PLOS NEGLECTED TROPICAL DISEASES (2018)
Frequency of Loss of Function Variants in LRRK2 in Parkinson Disease
Cornelis Blauwendraat et al.
JAMA NEUROLOGY (2018)
ClinVar at five years: Delivering on the promise
Melissa J. Landrum et al.
HUMAN MUTATION (2018)
Function and regulation of the Caenorhabditis elegans Rab32 family member GLO-1 in lysosome-related organelle biogenesis
Caitlin Morris et al.
PLOS GENETICS (2018)
RAB7L1-Mediated Relocalization of LRRK2 to the Golgi Complex Causes Centrosomal Deficits via RAB8A
Jesus Madero-Perez et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)
Tau Pathology in Parkinson's Disease
Xue Zhang et al.
FRONTIERS IN NEUROLOGY (2018)
Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations
Masashi Takanashi et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2018)
LRRK 2 gene mutations in the pathophysiology of the ROCO domain and therapeutic targets for Parkinson's disease: a review
Meng-Ling Chen et al.
JOURNAL OF BIOMEDICAL SCIENCE (2018)
Behavioral Mechanisms That Depend on Dopamine and Serotonin in Caenorhabditis elegans Interact With the Antipsychotics Risperidone and Aripiprazole
Jaime Osuna-Luque et al.
JOURNAL OF EXPERIMENTAL NEUROSCIENCE (2018)
OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes
Woojin Kim et al.
GENETICS (2018)
Rab29 activation of the Parkinson's disease-associated LRRK2 kinase
Elena Purlyte et al.
EMBO JOURNAL (2018)
GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2
Marian Blanca Ramirez et al.
HUMAN MOLECULAR GENETICS (2017)
Rab32 connects ER stress to mitochondrial defects in multiple sclerosis
Yohannes Haile et al.
JOURNAL OF NEUROINFLAMMATION (2017)
Advances in progressive supranuclear palsy: new diagnostic criteria, biomarkers, and therapeutic approaches
Adam L. Boxer et al.
LANCET NEUROLOGY (2017)
Pathogenic LRRK2 variants are gain-of-function mutations that enhance LRRK2-mediated repression of β-catenin signaling
Daniel C. Berwick et al.
MOLECULAR NEURODEGENERATION (2017)
A proteomic analysis of LRRK2 binding partners reveals interactions with multiple signaling components of the WNT/PCP pathway
Alena Salasova et al.
MOLECULAR NEURODEGENERATION (2017)
A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci
Diana Chang et al.
NATURE GENETICS (2017)
α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling
Audrey T. Medeiros et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2017)
Pink1 interacts with alpha-synuclein and abrogates alpha-synuclein-induced neurotoxicity by activating autophagy
Jia Liu et al.
CELL DEATH & DISEASE (2017)
A homologue of the Parkinson's disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover
Egon Deyaert et al.
NATURE COMMUNICATIONS (2017)
The Synucleinopathies: Twenty Years On
Michel Goedert et al.
JOURNAL OF PARKINSONS DISEASE (2017)
VPS35, the Retromer Complex and Parkinson's Disease
Erin T. Williams et al.
JOURNAL OF PARKINSONS DISEASE (2017)
UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes
Bikash Choudhary et al.
PLOS GENETICS (2017)
Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis
Martin Steger et al.
ELIFE (2017)
The Role of Co-chaperones in Synaptic Proteostasis and Neurodegenerative Disease
Erica L. Gorenberg et al.
FRONTIERS IN NEUROSCIENCE (2017)
LRRK2 Antisense Oligonucleotides Ameliorate α-Synuclein Inclusion Formation in a Parkinson's Disease Mouse Model
Hien Tran Zhao et al.
MOLECULAR THERAPY-NUCLEIC ACIDS (2017)
Behavioral Phenotyping and Pathological Indicators of Parkinson's Disease in C. elegans Models
Malabika Maulik et al.
Frontiers in Genetics (2017)
Nicotine from cigarette smoking and diet and Parkinson disease: a review
Chaoran Ma et al.
TRANSLATIONAL NEURODEGENERATION (2017)
Novel animal model defines genetic contributions for neuron-to-neuron transfer of α-synuclein
Trevor Tyson et al.
SCIENTIFIC REPORTS (2017)
Cryo-EM analysis of homodimeric full-length LRRK2 and LRRK1 protein complexes
Kushal Sejwal et al.
SCIENTIFIC REPORTS (2017)
Excessive burden of lysosomal storage disorder gene variants in Parkinson's disease
Laurie A. Robak et al.
BRAIN (2017)
Genetic and Pharmacological Discovery for Alzheimer's Disease Using Caenorhabditis elegans
Edward F. Griffin et al.
ACS CHEMICAL NEUROSCIENCE (2017)
New Genes Causing Hereditary Parkinson's Disease or Parkinsonism
Andreas Puschmann
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS (2017)
C9orf72 and RAB7L1 regulate vesicle trafficking in amyotrophic lateral sclerosis and frontotemporal dementia
Yoshitsugu Aoki et al.
BRAIN (2017)
LRRK2 levels in immune cells are increased in Parkinson'sdisease
D. A. Cook et al.
NPJ PARKINSONS DISEASE (2017)
Discovery and functional prioritization of Parkinson's disease candidate genes from large-scale whole exome sequencing
Iris E. Jansen et al.
GENOME BIOLOGY (2017)
LRRK2 Promotes Tau Accumulation, Aggregation and Release
Patricia Silva Guerreiro et al.
MOLECULAR NEUROBIOLOGY (2016)
A Systematic RNAi Screen of Neuroprotective Genes Identifies Novel Modulators of Alpha-Synuclein-Associated Effects in Transgenic Caenorhabditis elegans
Pooja Jadiya et al.
MOLECULAR NEUROBIOLOGY (2016)
DNAJC6 Mutations Associated With Early-Onset Parkinson's Disease
Simone Olgiati et al.
ANNALS OF NEUROLOGY (2016)
Chaperone complex BAG2-HSC70 regulates localization of Caenorhabditis elegans leucine-rich repeat kinase LRK-1 to the Golgi
Takashi Fukuzono et al.
GENES TO CELLS (2016)
CRISPR-Based Methods for Caenorhabditis elegans Genome Engineering
Daniel J. Dickinson et al.
GENETICS (2016)
Additional rare variant analysis in Parkinson's disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance
Steven J. Lubbe et al.
HUMAN MOLECULAR GENETICS (2016)
A familial ATP13A2 mutation enhances alpha-synuclein aggregation and promotes cell death
Tomas Lopes da Fonseca et al.
HUMAN MOLECULAR GENETICS (2016)
Identification of biallelic LRRK1 mutations in osteosclerotic metaphyseal dysplasia and evidence for locus heterogeneity
Aritoshi Iida et al.
JOURNAL OF MEDICAL GENETICS (2016)
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance
Dena G. Hernandez et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model
Ghulam Jeelani Pir et al.
MOLECULAR NEURODEGENERATION (2016)
Autophagy and Alpha-Synuclein: Relevance to Parkinson's Disease and Related Synucleopathies
Maria Xilouri et al.
MOVEMENT DISORDERS (2016)
Genome-wide analysis of genetic correlation in dementia with Lewy bodies, Parkinson's and Alzheimer's diseases
Rita Guerreiro et al.
NEUROBIOLOGY OF AGING (2016)
Structural model of the dimeric Parkinson's protein LRRK2 reveals a compact architecture involving distant interdomain contacts
Giambattista Guaitoli et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
The C. elegans Connectome Consists of Homogenous Circuits with Defined Functional Roles
Aharon Azulay et al.
PLOS COMPUTATIONAL BIOLOGY (2016)
Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases
Martin Steger et al.
ELIFE (2016)
Premotor Symptoms as Predictors of Outcome in Parkinsons Disease: A Case-Control Study
Yu-Hsuan Wu et al.
PLOS ONE (2016)
LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts
Tomoki Kuwahara et al.
SCIENTIFIC REPORTS (2016)
Widespread Proteome Remodeling and Aggregation in Aging C-elegans
Dirk M. Walther et al.
CELL (2015)
High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes
Alexandre Paix et al.
GENETICS (2015)
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
Joao P. L. Daher et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Prediagnostic presentations of Parkinson's disease in primary care: a case-control study
Anette Schrag et al.
LANCET NEUROLOGY (2015)
Loss of pdr-1/parkin influences Mn homeostasis through altered ferroportin expression in C-elegans
Sudipta Chakraborty et al.
METALLOMICS (2015)
Detecting balancing selection in genomes: limits and prospects
Anna Fijarczyk et al.
MOLECULAR ECOLOGY (2015)
VPS35 and EIF4G1 Interactions and Novel Candidate Genes for PD: From Genes to Pathways and Back
Roberto Erro
MOVEMENT DISORDERS (2015)
MDS clinical diagnostic criteria for Parkinson's disease
Ronald B. Postuma et al.
MOVEMENT DISORDERS (2015)
Inhibition of clathrin-mediated endocytosis prevents amyloid β-induced axonal damage
Tomoharu Kuboyama et al.
NEUROBIOLOGY OF AGING (2015)
Age-specific penetrance of LRRK2 G2019S in the Michael J. Fox Ashkenazi Jewish LRRK2 Consortium
Karen Marder et al.
NEUROLOGY (2015)
Analysis of several loci from genome-wide association studies in Parkinson's disease in mainland China
Zhen-hua Liu et al.
NEUROSCIENCE LETTERS (2015)
Mitochondrial Morphology and Fundamental Parameters of the Mitochondrial Respiratory Chain Are Altered in Caenorhabditis elegans Strains Deficient in Mitochondrial Dynamics and Homeostasis Processes
Anthony L. Luz et al.
PLOS ONE (2015)
Evidence for α-synuclein prions causing multiple system atrophy in humans with parkinsonism
Stanley B. Prusiner et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2015)
Effect of selective LRRK2 kinase inhibition on nonhuman primate lung
Reina N. Fuji et al.
SCIENCE TRANSLATIONAL MEDICINE (2015)
Retromer-dependent neurotransmitter receptor trafficking to synapses is altered by the Parkinson's disease VPS35 mutation p.D620N
L. N. Munsie et al.
HUMAN MOLECULAR GENETICS (2015)
Delaying aging is neuroprotective in Parkinson's disease: a genetic analysis in C. elegans models
Jason F. Cooper et al.
NPJ PARKINSONS DISEASE (2015)
Mutations in RAB39B Cause X-Linked Intellectual Disability and Early-Onset Parkinson Disease with α-Synuclein Pathology
Gabrielle R. Wilson et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2014)
DNAJC13 mutations in Parkinson disease
Carles Vilarino-Gueell et al.
HUMAN MOLECULAR GENETICS (2014)
Parkinson's disease-linked mutations in VPS35 induce dopaminergic neurodegeneration
Elpida Tsika et al.
HUMAN MOLECULAR GENETICS (2014)
A Parkinson's disease gene regulatory network identifies the signaling protein RGS2 as a modulator of LRRK2 activity and neuronal toxicity
Julien Dusonchet et al.
HUMAN MOLECULAR GENETICS (2014)
Soluble, Prefibrillar α-Synuclein Oligomers Promote Complex I-dependent, Ca2+-induced Mitochondrial Dysfunction
Eric S. Luth et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
VPS35 Parkinson's disease phenotype resembles the sporadic disease
Walter Struhal et al.
JOURNAL OF NEURAL TRANSMISSION (2014)
Differential protein-protein interactions of LRRK1 and LRRK2 indicate roles in distinct celluar signaling pathways
Lauran Reyniers et al.
JOURNAL OF NEUROCHEMISTRY (2014)
Frontotemporal dementia and its subtypes: a genome-wide association study
Raffaele Ferrari et al.
LANCET NEUROLOGY (2014)
VPS35 dysfunction impairs lysosomal degradation of α-synuclein and exacerbates neurotoxicity in a Drosophila model of Parkinson's disease
Emiko Miura et al.
NEUROBIOLOGY OF DISEASE (2014)
Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats
Joao P. L. Daher et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Unbiased screen for interactors of leucine-rich repeat kinase 2 supports a common pathway for sporadic and familial Parkinson disease
Alexandria Beilina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Mitochondrial dysfunction, oxidative stress, and neurodegeneration elicited by a bacterial metabolite in a C. elegans Parkinson's model
A. Ray et al.
CELL DEATH & DISEASE (2014)
PDR-1/hParkin negatively regulates the phagocytosis of apoptotic cell corpses in Caenorhabditis elegans
J. Cabello et al.
CELL DEATH & DISEASE (2014)
Alpha-synuclein biology in Lewy body diseases
Woojin Scott Kim et al.
ALZHEIMERS RESEARCH & THERAPY (2014)
Disease Penetrance of Late-Onset Parkinsonism A Meta-analysis
Joanne Trinh et al.
JAMA NEUROLOGY (2014)
The million mutation project: A new approach to genetics in Caenorhabditis elegans
Owen Thompson et al.
GENOME RESEARCH (2013)
GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2
Alice Biosa et al.
HUMAN MOLECULAR GENETICS (2013)
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity
Chen Yao et al.
HUMAN MOLECULAR GENETICS (2013)
PTL-1 regulates neuronal integrity and lifespan in C-elegans
Yee Lian Chew et al.
JOURNAL OF CELL SCIENCE (2013)
Interplay of LRRK2 with chaperone-mediated autophagy
Samantha J. Orenstein et al.
NATURE NEUROSCIENCE (2013)
RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson's Disease Risk
David A. MacLeod et al.
NEURON (2013)
Retromer Dependent Recycling of the Wnt Secretion Factor Wls Is Dispensable for Stem Cell Maintenance in the Mammalian Intestinal Epithelium
Reinoud E. A. de Groot et al.
PLOS ONE (2013)
Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimers diseases
Giovanni Coppola et al.
HUMAN MOLECULAR GENETICS (2012)
RAB-6.2 and the retromer regulate glutamate receptor recycling through a retrograde pathway
Donglei Zhang et al.
JOURNAL OF CELL BIOLOGY (2012)
A multi-centre clinico-genetic analysis of the VPS35 gene in Parkinson disease indicates reduced penetrance for disease-associated variants
Manu Sharma et al.
JOURNAL OF MEDICAL GENETICS (2012)
The MAPT p.A152T variant is a risk factor associated with tauopathies with atypical clinical and neuropathological features
Eleanna Kara et al.
NEUROBIOLOGY OF AGING (2012)
The location and trafficking routes of the neuronal retromer and its role in amyloid precursor protein transport
Akhil Bhalla et al.
NEUROBIOLOGY OF DISEASE (2012)
Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
Randall J. Bateman et al.
NEW ENGLAND JOURNAL OF MEDICINE (2012)
Biochemical Characterization of Highly Purified Leucine-Rich Repeat Kinases 1 and 2 Demonstrates Formation of Homodimers
Laura Civiero et al.
PLOS ONE (2012)
Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations
Zejuan Sheng et al.
SCIENCE TRANSLATIONAL MEDICINE (2012)
α-synuclein, LRRK2 and their interplay in Parkinson's disease
Guoxiang Liu et al.
FUTURE NEUROLOGY (2012)
A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
Alexander Zimprich et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
VPS35 Mutations in Parkinson Disease
Carles Vilarino-Gueell et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2011)
Replication of GWAS Associations for GAK and MAPT in Parkinson's Disease
Shannon L. Rhodes et al.
ANNALS OF HUMAN GENETICS (2011)
Neuroblast migration along the anteroposterior axis of C. elegans is controlled by opposing gradients of Wnts and a secreted Frizzled-related protein
Martin Harterink et al.
DEVELOPMENT (2011)
Parkinson's disease-linked LRRK2 is expressed in circulating and tissue immune cells and upregulated following recognition of microbial structures
Mansoureh Hakimi et al.
JOURNAL OF NEURAL TRANSMISSION (2011)
Association of LRRK2 exonic variants and susceptibility to Parkinson's disease: a case-control study (vol 10, pg 898, 2011)
O. A. Ross et al.
LANCET NEUROLOGY (2011)
Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2
Xianming Deng et al.
NATURE CHEMICAL BIOLOGY (2011)
LRRK2 expression in idiopathic and G2019S positive Parkinson's disease subjects: a morphological and quantitative study
S. Sharma et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2011)
LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
Jean-Marc Taymans et al.
PLOS ONE (2011)
Association of LRRK2 exonic variants with susceptibility to Parkinson's disease: a case-control study
Owen A. Ross et al.
LANCET NEUROLOGY (2011)
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1
Frits Kamp et al.
EMBO JOURNAL (2010)
Genetic variability at the PARK16 locus
Arianna Tucci et al.
EUROPEAN JOURNAL OF HUMAN GENETICS (2010)
Global microRNA Expression Profiling of Caenorhabditis elegans Parkinson's Disease Models
Suvi Asikainen et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2010)
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria (vol 8, pg 1150, 2009)
D. W. Dickson et al.
LANCET NEUROLOGY (2010)
Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
Byoung Dae Lee et al.
NATURE MEDICINE (2010)
LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease
Chen Yao et al.
NEUROBIOLOGY OF DISEASE (2010)
Neuropothological assessment of Parkinson's disease: refining the diagnostic criteria. (vol 8, pg 1150, 2009)
D. W. Dickson et al.
LANCET NEUROLOGY (2010)
The R1441C mutation alters the folding properties of the ROC domain of LRRK2
Yongchao Li et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2009)
The function of ROCO proteins in health and disease
Patrick A. Lewis
BIOLOGY OF THE CELL (2009)
DOG 1.0: illustrator of protein domain structures
Jian Ren et al.
CELL RESEARCH (2009)
Mutations in the LRRK2 Roc-COR tandem domain link Parkinson's disease to Wnt signalling pathways
Rosa M. Sancho et al.
HUMAN MOLECULAR GENETICS (2009)
Caenorhabditits elegans LRK-1 and PINK-1 Act Antagonistically in Stress Response and Neurite Outgrowth
Julia Saermann et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
LRRK2 Modulates Vulnerability to Mitochondrial Dysfunction in Caenorhabditis elegans
Shamol Saha et al.
JOURNAL OF NEUROSCIENCE (2009)
Genomewide Association Study of Leprosy
Fu-Ren Zhang et al.
NEW ENGLAND JOURNAL OF MEDICINE (2009)
A β-Catenin-Dependent Wnt Pathway Mediates Anteroposterior Axon Guidance in C. elegans Motor Neurons
Geraldine S. Maro et al.
PLOS ONE (2009)
Neuropathological assessment of Parkinson's disease: refining the diagnostic criteria
Dennis W. Dickson et al.
LANCET NEUROLOGY (2009)
The retromer complex influences Wnt secretion by recycling Wntless from endosomes to the trans-Golgi network
Tatyana Y. Belenkaya et al.
DEVELOPMENTAL CELL (2008)
C-elegans AP-2 and retromer control Wnt signaling by regulating MIG-14/Wntless
Chun-Liang Pan et al.
DEVELOPMENTAL CELL (2008)
The Parkinson disease-associated leucine-rich repeat kinase 2 (LRRK2) is a dimer that undergoes intramolecular autophosphorylation
Elisa Greggio et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Ancient origin of the Parkinson disease gene LRRK2
Ignacio Marin
JOURNAL OF MOLECULAR EVOLUTION (2008)
Investigating convergent actions of genes linked to familial Parkinson's disease
Benjamin Wolozin et al.
NEURODEGENERATIVE DISEASES (2008)
Autosomal dominant dopa-responsive parkinsonism in a multigenerational Swiss family
C. Wider et al.
PARKINSONISM & RELATED DISORDERS (2008)
C-elegans RPM-1 regulates axon termination and synaptogenesis through the Rab GEF GLO-4 and the Rab GTPase GLO-1
Brock Grill et al.
NEURON (2007)
The R1441C mutation of LRRK2 disrupts GTP hydrolysis
Patrick A. Lewis et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
ATP13A2 missense mutations in juvenile parkinsonism and young onset Parkinson disease
A. Di Fonzo et al.
NEUROLOGY (2007)
LRK-1, a C-elegans PARK8-Related kinase, regulates axonal-dendritic polarity of SV proteins
Aisa Sakaguchi-Nakashima et al.
CURRENT BIOLOGY (2007)
Parkinson's disease-associated mutations in LRRK2 link enhanced GTP-binding and kinase activities to neuronal toxicity
Andrew B. West et al.
HUMAN MOLECULAR GENETICS (2007)
The Parkinson disease gene LRRK2:: Evolutionary and structural insights
Ignacio Marin
MOLECULAR BIOLOGY AND EVOLUTION (2006)
Mutations in DJ-1 are rare in familial Parkinson disease
Nathan Pankratz et al.
NEUROSCIENCE LETTERS (2006)
Genome-wide genotyping in Parkinson's disease and neurologically normal controls:: first stage analysis and public release of data
Hon-Chung Fung et al.
LANCET NEUROLOGY (2006)
Kinase activity of mutant LRRK2 mediates neuronal toxicity
Wanli W. Smith et al.
NATURE NEUROSCIENCE (2006)
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin
Elisa Greggio et al.
NEUROBIOLOGY OF DISEASE (2006)
Wnt gradient formation requires retromer function in Wnt-producing cells
DYM Coudreuse et al.
SCIENCE (2006)
Wnt signaling establishes anteroposterior neuronal polarity and requires retromer in C-elegans
BC Prasad et al.
DEVELOPMENT (2006)
Mutational analysis of the PINK1 gene in early-onset parkinsonism in Europe and North Africa
P Ibáñez et al.
BRAIN (2006)
The Parkinson disease causing LRRK2 mutation I2020T is associated with increased kinase activity
CJ Gloeckner et al.
HUMAN MOLECULAR GENETICS (2006)
Familial Parkinson mutant α-synuclein causes dopamine neuron dysfunction in transgenic Caenorhabditis elegans
T Kuwahara et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Model-guided microarray implicates the retromer complex in Alzheimer's disease
SA Small et al.
ANNALS OF NEUROLOGY (2005)
Parkinson's disease-associated mutations in leucine-rich repeat kinase 2 augment kinase activity
AB West et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
A Caenorhabditis elegans Parkin mutant with altered solubility couples α-synuclein aggregation to proteotoxic stress
W Springer et al.
HUMAN MOLECULAR GENETICS (2005)
Genetic analysis of lysosomal trafficking in Caenorhabditis elegans
GJ Hermann et al.
MOLECULAR BIOLOGY OF THE CELL (2005)
Cloning of the gene containing mutations that cause PARK8-linked Parkinson's disease
C Paisán-Ruíz et al.
NEURON (2004)
Mutations in LRRK2 cause autosomal-dominant Parkinsonism with pleomorphic pathology
A Zimprich et al.
NEURON (2004)
Dopaminergic neuronal loss and motor deficits in Caenorhabditis elegans overexpressing human α-synuclein
M Lakso et al.
JOURNAL OF NEUROCHEMISTRY (2003)
Idiopathic Parkinson's disease:: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen
H Braak et al.
JOURNAL OF NEURAL TRANSMISSION (2003)
Staging of brain pathology related to sporadic Parkinson's disease
H Braak et al.
NEUROBIOLOGY OF AGING (2003)
Systematic functional analysis of the Caenorhabditis elegans genome using RNAi
RS Kamath et al.
NATURE (2003)
Signal transduction - The guanine nucleotide-binding switch in three dimensions
IR Vetter et al.
SCIENCE (2001)
WormBase: network access to the genome and biology of Caenorhabditis elegans
L Stein et al.
NUCLEIC ACIDS RESEARCH (2001)
C-elegans locomotory rate is modulated by the environment through a dopaminergic pathway and by experience through a serotonergic pathway
ER Sawin et al.
NEURON (2000)