Journal
BIOORGANIC CHEMISTRY
Volume 114, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2021.105112
Keywords
Sprout; Senna tora; Fabaceae; Naphthopyrone; Antioxidant; Neuroprotective effect
Funding
- Korea Institute of Science & Technology Program [2E31300]
- KHU-KIST Converging Science and Technology-Joint Research Program
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The extract from Senna tora sprouts, rich in phenolic constituents, shows improved radical scavenging activities and neuroprotective effects, making it a potential natural neuroprotective agent.
The consumption of sprouts has been steadily increasing due to their being an excellent source of nutrition. It is known that the bioactive constituents of legumes can be increased after germination. In this study, the extract from Senna tora sprouts is shown to exhibit improved radical scavenging activities and better neuroprotective effects in HT22 hippocampal neuronal (HT22) and R28 retina precursor (R28) cells than those from seeds due to an increased content of phenolic constituents, especially compounds 1 and 3-6. A phytochemical investigation of S. tora sprouts resulted in the isolation of two new naphthopyrone glycosides (1-2) with 27 previously reported compounds. Their structures were determined via interpreting spectroscopic data. Compounds 1 and 3-6 were found to possess radical scavenging activities and neuroprotective effects against oxidative stress in both neuronal cells. Hence, Senna tora sprouts and their constituents may be developed as natural neuroprotective agents via antioxidative effects.
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