Related references
Note: Only part of the references are listed.Conjugates of tacrine and 1,2,4-thiadiazole derivatives as new potential multifunctional agents for Alzheimer's disease treatment: Synthesis, quantum-chemical characterization, molecular docking, and biological evaluation
Galina F. Makhaeva et al.
BIOORGANIC CHEMISTRY (2020)
Design, synthesis and biological evaluation of 2,3-dihydro-5,6-dimethoxy-1H-inden-1-one and piperazinium salt hybrid derivatives as hAChE and hBuChE enzyme inhibitors
Sakineh Mozaffarnia et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2020)
Bis-γ-carbolines as new potential multitarget agents for Alzheimer's disease
Galina F. Makhaeva et al.
PURE AND APPLIED CHEMISTRY (2020)
A Perspective on Multi-target Drugs for Alzheimer's Disease
Ondrej Benek et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2020)
Scalable molecular dynamics on CPU and GPU architectures with NAMD
James C. Phillips et al.
JOURNAL OF CHEMICAL PHYSICS (2020)
New Hybrids of 4-Amino-2,3-polymethylene-quinoline andp-Tolylsulfonamide as Dual Inhibitors of Acetyl- and Butyrylcholinesterase and Potential Multifunctional Agents for Alzheimer's Disease Treatment
Galina F. Makhaeva et al.
MOLECULES (2020)
Towards Deep Neural Network Models for the Prediction of the Blood-Brain Barrier Permeability for Diverse Organic Compounds
Eugene V. Radchenko et al.
MOLECULES (2020)
Therapeutic Potential of Multifunctional Tacrine Analogues
Maja Przybylowska et al.
CURRENT NEUROPHARMACOLOGY (2019)
Development of Multifunctional Molecules as Potential Therapeutic Candidates for Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis in the Last Decade
Masha G. Savelieff et al.
CHEMICAL REVIEWS (2019)
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018)
Pankaj Mishra et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2019)
Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory
Prabhash Nath Tripathi et al.
BIOORGANIC CHEMISTRY (2019)
Overview of novel multifunctional agents based on conjugates of γ-carbolines, carbazoles, tetrahydrocarbazoles, phenothiazines, and aminoadamantanes for treatment of Alzheimer's disease
Galina F. Makhaeva et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2019)
Cholinesterase and carboxylesterase inhibitors as pharmacological agents
G. F. Makhaeva et al.
RUSSIAN CHEMICAL BULLETIN (2019)
New evidence for dual binding site inhibitors of acetylcholinesterase as improved drugs for treatment of Alzheimer's disease
Irina Zueva et al.
NEUROPHARMACOLOGY (2019)
Design and Synthesis of Selective Acetylcholinesterase Inhibitors: Arylisoxazole-Phenylpiperazine Derivatives
Mina Saeedi et al.
CHEMISTRY & BIODIVERSITY (2019)
Conjugates of methylene blue with γ-carboline derivatives as new multifunctional agents for the treatment of neurodegenerative diseases
Sergey O. Bachurin et al.
SCIENTIFIC REPORTS (2019)
Alzheimer's Disease, the One-Molecule, One-Target Paradigm, and the Multitarget Directed Ligand Approach
Maria Jesus Oset-Gasque et al.
ACS CHEMICAL NEUROSCIENCE (2018)
A molecular approach in drug development for Alzheimer's disease
Snezana Agatonovic-Kustrin et al.
BIOMEDICINE & PHARMACOTHERAPY (2018)
Synthesis and evaluation of coumarin/piperazine hybrids as acetylcholinesterase inhibitors
Juan Zhang et al.
MEDICINAL CHEMISTRY RESEARCH (2018)
Mild cognitive impairment due to Alzheimer disease: Contemporary approaches to diagnostics and pharmacological intervention
Sergey O. Bachurin et al.
PHARMACOLOGICAL RESEARCH (2018)
Spinal mechanisms of neuroplasticity induced by neuromidin in treatment of traumatic neuropathies
S. A. Zhivolupov et al.
Zhurnal Nevrologii I Psikhiatrii imeni S S Korsakova (2018)
Exploring Activity Profiles of PAINS and Their Structural Context in Target-Ligand Complexes
Vishal B. Siramshetty et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2018)
Design, synthesis, in-silico and biological evaluation of novel donepezil derivatives as multi-target-directed ligands for the treatment of Alzheimer's disease
Chandra Bhushan Mishra et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
A review on tacrine-based scaffolds as multi-target drugs (MTDLs) for Alzheimer's disease
Bilqees Sameem et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2017)
Phantom PAINS: Problems with the Utility of Alerts for Pan-Assay INterference CompoundS
Stephen J. Capuzzi et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2017)
How Frequently Are Pan-Assay Interference Compounds Active? Large-Scale Analysis of Screening Data Reveals Diverse Activity Profiles, Low Global Hit Frequency, and Many Consistently Inactive Compounds
Swarit Jasial et al.
JOURNAL OF MEDICINAL CHEMISTRY (2017)
A benzothiazole/piperazine derivative with acetylcholinesterase inhibitory activity: Improvement in streptozotocin-induced cognitive deficits in rats
Umide Demir Ozkay et al.
PHARMACOLOGICAL REPORTS (2017)
Multitarget compounds bearing tacrine- and donepezil-like structural and functional motifs for the potential treatment of Alzheimer's disease
Lhassane Ismaili et al.
PROGRESS IN NEUROBIOLOGY (2017)
Focused design of polypharmacophoric neuroprotective compounds: Conjugates of γ-carbolines with carbazole derivatives and tetrahydrocarbazole
Galina F. Makhaeva et al.
PURE AND APPLIED CHEMISTRY (2017)
Novel conjugates of aminoadamantanes with carbazole derivatives as potential multitarget agents for AD treatment
Sergey O. Bachurin et al.
SCIENTIFIC REPORTS (2017)
Tacrine-based Multifunctional Agents in Alzheimer's Disease: An Old Story in Continuous Development
Andrea Milelli et al.
CURRENT MEDICINAL CHEMISTRY (2017)
Multitarget Tacrine Hybrids with Neuroprotective Properties to Confront Alzheimer's Disease
Katarina Spilovska et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2017)
Role of Acetylcholinesterase in β-Amyloid Aggregation Studied by Accelerated Molecular Dynamics
Sofya V. Lushchekina et al.
BIONANOSCIENCE (2017)
Computer-aided estimation of the hERG-mediated cardiotoxicity risk of potential drug components
E. V. Radchenko et al.
DOKLADY BIOCHEMISTRY AND BIOPHYSICS (2017)
A comparative analysis of the efficacy of neuromidin and galantamine in Alzheimer’s disease
S. A. Zhivolupov et al.
Zhurnal Nevrologii I Psikhiatrii imeni S S Korsakova (2016)
Synthesis, molecular docking and biological evaluation of N,N-disubstituted 2-aminothiazolines as a new class of butyrylcholinesterase and carboxylesterase inhibitors
Galina F. Makhaeva et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2016)
Design, synthesis, and AChE inhibitory activity of new benzothiazole-piperazines
Umide Demir Ozkay et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
Esterase profiles of organophosphorus compounds in vitro predict their behavior in vivo
Galina F. Makhaeva et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2016)
Novel 8-Hydroxyquinoline Derivatives as Multitarget Compounds for the Treatment of Alzheimer's Disease
Federica Prati et al.
CHEMMEDCHEM (2016)
Prediction of human intestinal absorption of drug compounds
E. V. Radchenko et al.
RUSSIAN CHEMICAL BULLETIN (2016)
Role of oxidative stress in Alzheimer's disease
Wen-Juan Huang et al.
BIOMEDICAL REPORTS (2016)
Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease
Poonam Meena et al.
BIOORGANIC & MEDICINAL CHEMISTRY (2015)
Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers
Poonam Piplani et al.
BIOORGANIC CHEMISTRY (2015)
Piperazine scaffold: A remarkable tool in generation of diverse pharmacological agents
Mohammad Shaquiquzzaman et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2015)
7-Methoxytacrine-p-Anisidine Hybrids as Novel Dual Binding Site Acetylcholinesterase Inhibitors for Alzheimer's Disease Treatment
Jan Korabecny et al.
MOLECULES (2015)
Conjugates of γ-Carbolines and Phenothiazine as new selective inhibitors of butyrylcholinesterase and blockers of NMDA receptors for Alzheimer Disease
Galina F. Makhaeva et al.
SCIENTIFIC REPORTS (2015)
Effects of Anti-Alzheimer Drugs on Phosphorylation and Assembly of Microtubules from Brain Microtubular Proteins
P. N. Shevtsov et al.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2014)
Multi-Target Directed Drugs: A Modern Approach for Design of New Drugs for the treatment of Alzheimer’s Disease
Kris Simone Tranches Dias et al.
Current Neuropharmacology (2014)
An update on drug treatment options of Alzheimer's disease
Michael Allgaier
Frontiers in Bioscience-Landmark (2014)
Apoptosis and Oxidative Stress in Neurodegenerative Diseases
Elena Radi et al.
JOURNAL OF ALZHEIMERS DISEASE (2014)
Organophosphorus compound esterase profiles as predictors of therapeutic and toxic effects
Galina F. Makhaeva et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2013)
Oxidative Stress and Amyloid Beta Toxicity in Alzheimer's Disease: Intervention in a Complex Relationship by Antioxidants
S. Chakrabarti et al.
CURRENT MEDICINAL CHEMISTRY (2013)
The Multifactorial Nature of Alzheimer's Disease for Developing Potential Therapeutics
M. Carmo Carreiras et al.
CURRENT TOPICS IN MEDICINAL CHEMISTRY (2013)
Rapid Parameterization of Small Molecules Using the Force Field Toolkit
Christopher G. Mayne et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2013)
Protonation and pK changes in protein-ligand binding
Alexey V. Onufriev et al.
QUARTERLY REVIEWS OF BIOPHYSICS (2013)
Alzheimer Mechanisms and Therapeutic Strategies
Yadong Huang et al.
CELL (2012)
Galantamine-based Hybrid Molecules with Acetylcholinesterase, Butyrylcholinesterase and γ-Secretase Inhibition Activities
L. Vezenkov et al.
CURRENT ALZHEIMER RESEARCH (2012)
New Tacrine-4-Oxo-4H-chromene Hybrids as Multifunctional Agents for the Treatment of Alzheimer's Disease, with Cholinergic, Antioxidant, and β-Amyloid-Reducing Properties
Maria Isabel Fernandez-Bachiller et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Structures of Human Acetylcholinesterase in Complex with Pharmacologically Important Ligands
Jonah Cheung et al.
JOURNAL OF MEDICINAL CHEMISTRY (2012)
Quantifying the chemical beauty of drugs
G. Richard Bickerton et al.
NATURE CHEMISTRY (2012)
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease
Michela Rosini et al.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY (2011)
Online chemical modeling environment (OCHEM): web platform for data storage, model development and publishing of chemical information
I Sushko et al.
Journal of Cheminformatics (2011)
Tacrine-based dual binding site acetylcholinesterase inhibitors as potential disease-modifying anti-Alzheimer drug candidates
Pelayo Camps et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2010)
Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database
Paul C. D. Hawkins et al.
JOURNAL OF CHEMICAL INFORMATION AND MODELING (2010)
AutoDock4 and AutoDockTools4: Automated Docking with Selective Receptor Flexibility
Garrett M. Morris et al.
JOURNAL OF COMPUTATIONAL CHEMISTRY (2009)
Neuroprotective and Cholinergic Properties of Multifunctional Glutamic Acid Derivatives for the Treatment of Alzheimer's Disease
Mariana P. Arce et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Effect of tacrine, amiridine, akatinol memantine, and triazolam on phosphorylation, structure, and assembly of microtubules from brain microtubular proteins in Alzheimer diseases
P. N. Shevtsov et al.
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE (2008)
Amyloid-cholinesterase interactions - Implications for Alzheimer's disease
Nibaldo C. Inestrosa et al.
FEBS JOURNAL (2008)
Multi-target-directed ligands to combat neurodegenerative diseases
Andrea Cavalli et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
A short history of SHELX
George M. Sheldrick
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES (2008)
Inhibition of two different cholinesterases by tacrine
Mushtaq Ahmed et al.
CHEMICO-BIOLOGICAL INTERACTIONS (2006)
Targeting acetylcholinesterase and butyrylcholinesterase in dementia
RM Lane et al.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY (2006)
Novel cholinesterase inhibitors as future effective drugs for the treatment of Alzheimer's disease
A Martinez et al.
EXPERT OPINION ON INVESTIGATIONAL DRUGS (2006)
Effects of switching from an AChE inhibitor to a dual AChE-BuChE inhibitor in patients with Alzheimer's disease
L Bartorelli et al.
CURRENT MEDICAL RESEARCH AND OPINION (2005)
An examination of self-reported chronic conditions and health status in the 2001 Medicare Health Outcomes Survey
Y Ko et al.
CURRENT MEDICAL RESEARCH AND OPINION (2005)
Crystal structure of human butyrylcholinesterase and of its complexes with substrate and products
Y Nicolet et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site
Y Bourne et al.
EMBO JOURNAL (2003)
A structural motif of acetylcholinesterase that promotes amyloid β-peptide fibril formation
GV De Ferrari et al.
BIOCHEMISTRY (2001)
Interaction kinetics of reversible inhibitors and substrates with acetylcholinesterase and its fasciculin 2 complex
Z Radic et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
Kinetic analysis of the toxicological effect of tacrine (Cognex®) on human retinal acetylcholinesterase activity
AS Alhomida et al.
TOXICOLOGY (2000)
Share Paper
