Journal
BIOORGANIC CHEMISTRY
Volume 112, Issue -, Pages -Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2021.104977
Keywords
Ganoderma applanatum; Lanostane triterpenoids; Antiadipogenic effects
Funding
- National Natural Science Foundation of China [81172940, 31872675, 21702209]
- Foundation of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2010ZZ14]
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The study identified compounds in Ganoderma applanatum extract that have antiadipogenic effects, with a new compound showing potential in inhibiting adipogenesis. This suggests a new perspective for treating obesity by utilizing these compounds.
Previously, we have demonstrated the antiadipogenic benefits of Ganoderma triterpenoids (GTs), which indicated GTs have potential therapeutic implications for obesity. In this study, the EtOAc extract of Ganoderma applanatum was further phytochemically investigated for searching new antiadipogenic agents, which led to the isolation of a total of 15 highly oxygenated lanostane triterpenoids, including 9 new compounds (1-9) and 6 known analogues (10-15). Structurally, ganodapplanoic acids A and B (1, 2) are two rearranged 6/6/5/6-fused lanostane-type triterpenoids with an unusual C-13/C-15 oxygen bridge moiety. In addition, the EtOAc extract (GAE) and isolates (1-4,6-15) were assayed for their antiadipogenic effects in 3T3-L1 adipocytes. The results revealed that compound 9 effectively repressed adipogenesis through down-regulating the expression of major proteins (PPAR gamma, CEBP beta and FAS) involving differentiation and adipogenesis in 3T3-L1 adipocytes. Thus, the present study further demonstrated the antiadipogenic potential of GTs and provided a possible perspective for obesity treatment.
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