Oxadiazepinone HBV capsid assembly modulators

The HBV core protein serves multiple essential functions in the viral life cycle that enable chronic HBV infection to persist, and as such, represents a promising drug target. Modulation of the HBV capsid assembly has shown efficacy in early clinical trials through use of small molecule capsid assembly modulators (CAMs). Herein is described the evolution and SAR of a novel pyrazolo piperidine lead series into advanced oxadiazepinone HBV CAMs.

Automated summary

The HBV core protein plays multiple crucial roles in the viral life cycle, making it a promising drug target for chronic HBV infection. Modulation of HBV capsid assembly has shown effectiveness in early clinical trials through the use of small molecule capsid assembly modulators. The evolution and structure-activity relationship of a novel pyrazolo piperidine lead series into advanced oxadiazepinone HBV CAMs is described in this study.