Journal
EXPERIMENTAL EYE RESEARCH
Volume 142, Issue -, Pages 19-25Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.exer.2015.03.009
Keywords
Extracellular matrix; Epithelial-mesenchymal transition; Growth factor; Laser-induced choroidal neovascularization; Macrophage; Matricellular protein; Myofibroblasts; Subretinal scar
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Funding
- National Institutes of Health [EY03040, EY01545]
- Arnold and Mabel Beckman Foundation
- Research to Prevent Blindness, New York, NY
- Japan Society for Promotion of Science Postdoctoral Fellowships for Research Abroad
- NATIONAL EYE INSTITUTE [R01EY001545, P30EY003040] Funding Source: NIH RePORTER
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Subretinal fibrosis is a result of a wound healing response that follows choroidal neovascularization in neovascular age-related macular degeneration (nAMD). Although anti-vascular endothelial growth factor therapy has become a standard treatment that improves visual acuity in many nAMD patients, unsuccessful treatment outcomes have often been attributed to the progression of subretinal fibrosis. In this review, we summarize the cellular and extracellular components of subretinal fibrous membranes and also discuss the possible molecular mechanisms including the functional involvement of growth factors and the inflammatory response in the process. Moreover, we present an murine animal model of sub retinal fibrosis that might facilitate greater understanding of the pathophysiology and the development of novel therapeutic strategies for the inhibition of subretinal fibrosis in nAMD. (C) 2015 Elsevier Ltd. All rights reserved.
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