The interaction between miRNAs/lncRNAs and nuclear factor-?B (NF-?B) in human disorders

Nuclear factor-?B (NF-?B) represents a group of inducible transcription factors (TFs) regulating the expression of a great variety of genes implicated in diverse processes, particularly modulation of immune system responses. This TF has functional interactions with non-coding RNAs, constructing a complicated network through which NF-?B, miRNAs, and lncRNAs coordinately regulate gene expression at different facets. This type of interaction is involved in the pathophysiology of several human disorders including both neoplastic disorders and nonneoplastic conditions. MALAT1 and NKILA are among lncRNAs whose interactions with NF-?B have been vastly assessed in different conditions including cancer and inflammatory conditions. In addition, miR-146a/b has functional interactions with this TF in different contexts. Although miRNAs have mutual interactions with NF-?B, the regulatory role of miRNAs on this TF has been more clarified. The aim of the current review is to explore the function of NF-?B-related miRNAs and lncRNAs in these two types of human disorders.

Automated summary

NF-κB, a group of inducible transcription factors, interacts with miRNAs and lncRNAs to regulate gene expression, playing a crucial role in various diseases, including both neoplastic and nonneoplastic disorders.