Journal
BIOMEDICINE & PHARMACOTHERAPY
Volume 139, Issue -, Pages -Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111578
Keywords
SARS-CoV-2; Curcuma longa; Coronavirus; Nanotechnology; Natural products
Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior -Brazil (CAPES) [001]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico - Brazil (CNPQ)
- NIH [P41-GM103311]
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Curcumin and its nanostructured systems show potential as antiviral keys for treating SARS-CoV-2, with the possibility of improving treatment efficacy by increasing bioavailability and therapeutic efficiency.
The COVID-19 has become of striking interest since the number of deaths is constantly rising all over the globe, and the search for an efficient treatment is more urgent. In light of this worrisome scenario, this opinion review aimed to discuss the current knowledge about the potential role of curcumin and its nanostructured systems on the SARS-CoV-2 targets. From this perspective, this work demonstrated that curcumin urges as a potential antiviral key for the treatment of SARS-CoV-2 based on its relation to the infection pathways. Moreover, the use of curcumin-loaded nanocarriers for increasing its bioavailability and therapeutic efficiency was highlighted. Additionally, the potential of the nanostructured systems by themselves and their synergic action with curcumin on molecular targets for viral infections have been explored. Finally, a viewpoint of the studies that need to be carried out to implant curcumin as a treatment for COVID-19 was addressed.
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