Journal
BIOMEDICAL MATERIALS
Volume 16, Issue 4, Pages -Publisher
IOP PUBLISHING LTD
DOI: 10.1088/1748-605X/ac058a
Keywords
ferroptosis; iron-based nanomaterials; reactive oxygen species; lipid peroxidation; fenton reaction
Funding
- National Natural Science Foundation of China [31870997, 81770091]
- Shanghai Municipal Education Commission Innovative Program [2017-01-07-00-07-E00038]
- Fundamental Research Funds for the Central Universities
- Shanghai Pulmonary Hospital Innovation Program [FKCX1906]
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Ferroptosis is a novel form of programmed cell death that is expected to be an important cancer treatment strategy. Nanomaterials, particularly those based on iron, have been shown to be more efficient in inducing ferroptosis compared to traditional biological agents. However, distinguishing nanoparticle-induced ferroptosis from traditional strategies, elucidating detailed mechanisms, and further classifying nanomaterial synthesis methods remain challenging.
Ferroptosis is a new type of programmed cell death, which is expected to become an important strategy of cancer treatment. Traditional strategies for inducing iron death are small molecule inducers based on biological agents. However, because of their poor water solubility, low cell targeting ability and fast metabolism in vivo, it is difficult for molecular drugs to play the long-acting role of ferroptosis induction. With the further study of ferroptosis and development of nanotechnology, nanomaterials have been proved to be more efficient drugs for inducing ferroptosis than those biological drugs. Therein, iron-based nanomaterials can directly release high concentrations of irons and increase reactive oxygen species levels in cells, which produce a better induction effect for ferroptosis. Whereas, it is challenging to differentiate nanoparticle-induced ferroptosis and traditional inducing strategies, elucidate the detailed mechanisms and further classify the synthetical methods of nanomaterials. For better guidance on the development of anticancer strategies, comprehensive summary of the latest developments of ferroptosis related nanomaterials, especially iron-based nanomaterials are in urgent need. In the paper, we summarized the main mechanisms of ferroptosis, highlighted the latest developments of nanomaterials for ferroptosis, and emphasized the advantages of iron-based nanomaterials for ferroptosis. The future prospect in this field was also discussed, paving the way for the related nanomaterials in the clinical cancer therapy.
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