Journal
BIOMEDICAL CHROMATOGRAPHY
Volume 35, Issue 11, Pages -Publisher
WILEY
DOI: 10.1002/bmc.5201
Keywords
brexpiprazole; fruit juice-drug interaction; fruit juices; pharmacokinetics
Categories
Funding
- Department of Pharmaceuticals, Ministry of Chemicals and Fertilizers, India
Ask authors/readers for more resources
The study found that the combined administration of grapefruit juice and pomegranate juice increased the systemic exposure of Brexpiprazole and affected its pharmacokinetic parameters, while tomato juice had no significant effect.
Brexpiprazole (BRX) is approved for the treatment of schizophrenia and major depressive disorders and it is mainly metabolized by CYP3A4 and CYP2D6. Grapefruit juice (GFJ), pomegranate juice (PJ) and tomato juice (TJ) have the potential to inhibit CYP3A4 enzymes in the body. However, fruit juice-drug interactions between BRX and GFJ, PJ and TJ have not been studied extensively. The present study describes the influence of GFJ, PJ and TJ on the pharmacokinetic parameters of BRX in rats. The study samples were analyzed using a mass-accurate and single-step bioanalytical method by ultra-high-performance liquid chromatography-quadrupole time-of-flight mass spectrometry over a wide calibration range of 20-1,500 ng/ml. The results of the pharmacokinetic study denoted that the combined administration of GFJ and PJ could increase systemic exposure of BRX. The area under the curve of BRX increased 3.43- and 1.88-fold with co-administration of GFJ and PJ, respectively, while TJ with BRX had no effect on the area under the curve. Time to peak concentration and half-life were not significantly changed by any juice co-administration. The results show that GFJ and PJ affect the pharmacokinetic profile of BRX and hence advice needs to be given to patients.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available