Journal
BREAST CANCER RESEARCH AND TREATMENT
Volume 152, Issue 3, Pages 637-643Publisher
SPRINGER
DOI: 10.1007/s10549-015-3496-y
Keywords
Breast cancer; Bone health; Obesity; Weight loss; Bone mineral density
Categories
Funding
- National Cancer Institute [R21CA161105, CA148791]
- Washington University Institute of Clinical
- Translational Sciences Grant from the National Center for Advancing Translational Sciences (NCATS) of the National Institutes of Health (NIH) [UL1TR000448]
- Biostatistics Core at Siteman Cancer Center
- Washington University School of Medicine
- Barnes-Jewish Hospital Foundation
- Siteman Cancer Center
- Faculty Diversity Award
Ask authors/readers for more resources
Current guidelines recommend weight loss in obese cancer survivors. Weight loss, however, has adverse effects on bone health in obese individuals without cancer but this has not been evaluated in breast cancer survivors. We investigated the associations of intentional weight loss with bone mineral density (BMD) and bone turn-over markers in overweight/obese postmenopausal breast cancer survivors. Participants were overweight/obese breast cancer survivors (N = 81) with stage I, II or IIIA disease enrolled in the St. Louis site of a multi-site Exercise and Nutrition to Enhance Recovery and Good health for You (ENERGY) study; a randomized-controlled clinical trial designed to achieve a sustained a parts per thousand yen7 % loss in body weight at 2 years. Weight loss was achieved through dietary modification with the addition of physical activity. Generalized estimating equations were used to assess differences in mean values between follow-up and baseline. Mean weight decreased by 3 and 2.3 % between baseline and 6-month follow-up, and 12-month follow-up, respectively. There were decreases in osteocalcin (10.6 %, p value < 0.001), PINP (14.5 %, p value < 0.001), NTx (19.2 % p value < 0.001), and RANK (48.5 %, p value < 0.001), but not BALP and CTX-1 levels between baseline and 12-month follow-up. No significant changes occurred in mean T-scores, pelvis and lumbar spine BMD between baseline and 12-month follow-up. A 2.3 % weight loss over 12 months among overweight/obese women with early-stage breast cancer does not appear to have deleterious effect on bone health, and might even have beneficial effect. These findings warrant confirmation, particularly among breast cancer survivors with a larger magnitude of weight loss.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available