4.8 Article

Topical cationic hairy particles targeting cell free DNA in dermis enhance treatment of psoriasis

Journal

BIOMATERIALS
Volume 276, Issue -, Pages -

Publisher

ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.121027

Keywords

Cationic polymers; Cell free DNA; Inflammation; Nanoparticle; Psoriasis

Funding

  1. National Natural Science Foundation of China [21875290, 51820105004]
  2. Key Areas Research and Development Program of Guangzhou [202007020006]
  3. Sun Yat-sen University [19lgjc01]

Ask authors/readers for more resources

The study reveals that poly(2-(dimethylamino)ethyl methacrylate) (PDMA) grafted hairy silica particles (cSPs) with tunable PDMA length and particle size can effectively scavenge cfDNA in the dermis, treating psoriasis. Among them, cSPs of 700 nm diameter show excellent performance with more accumulation and longer retention in psoriatic lesions, leading to better treatment results at a lower administration frequency.
Abnormal high level of cell free DNA (cfDNA) triggers chronic inflammation to exacerbate psoriasis symptoms. Scavenging cfDNA by topical cationic polymeric nanoparticles has been certified as an effective therapeutic strategy for treating psoriasis. However, cationic cfDNA scavengers have a great potential risk to organs after entering systemic circulation through skin barrier. For better transformation to clinical application, herein a series of poly(2-(dimethylamino)ethyl methacrylate) (PDMA) grafted hairy silica particles (cSPs) with tunable PDMA length and particle size are applied to scavenge cfDNA in dermis. We reveal that the structure of cSPs correlates with the permeation ability across stratum corneum, retention time in dermis, binding affinity to cfDNA, and toxicity tolerance, which in turn affect the therapeutic effect. Especially, the cSPs of 700 nm show more accumulation and longer retention in psoriatic lesions, leading to excellent treatment results. They also outperform the cSPs of 200 nm at a lower administration frequency. Thus, we address the issues of size, cationic content of cSPs to open a potential new avenue to topically treatment of psoriasis by targeting cfDNA in dermis.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available