Journal
BIOMACROMOLECULES
Volume 22, Issue 10, Pages 4237-4243Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.1c00792
Keywords
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Funding
- Natural Science Foundation of Fujian Province, China [2020J05109]
- National Natural Science Foundation of China [81703271]
- Open Project Program of National Engineering Research Center for Environmental Photocatalysis, Fuzhou University [NERCEP-201908]
- Tianjin University-Fuzhou University Innovation Fund [TF2021-6]
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This study introduces a versatile strategy for site-selective synthesis of protein-polymer conjugates (PPCs), providing a facile technology for surface modification of biomacromolecules with desired polymers for various biomedical applications.
Formation of protein-polymer conjugates (PPCs) is critical for many studies in chemical biology, biomedicine, and enzymatic catalysis. Polymers with coordinated physicochemical properties confer synergistic functions to PPCs that overcome the inherent limitation of proteins. However, application of PPCs has been synthetically restricted by the limited modification sites and polymer grafting method. Here, we present a versatile strategy for site-selective PPC synthesis. The initiator was specifically tethered to the preoxidized glycan moieties through oxime chemistry. Polymer brushes were grown in situ from the glycan by atom-transfer radical polymerization to generate well-controlled PPCs. Notably, the modification is site-specific, multivalent, and alterable depending on protein glycosylation. Additionally, we demonstrated that the cytocompatible method enabled the growth of polymer chains from the surface of living yeast cells. These results verified a facile technology for surface modification of biomacromolecules by desired polymers for various biomedical applications.
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