4.5 Article

Apigenin Attenuates Mesoporous Silica Nanoparticles-Induced Nephrotoxicity by Activating FOXO3a

Related references

Note: Only part of the references are listed.
Article Neurosciences

Apigenin Modulates Dendritic Cell Activities and Curbs Inflammation Via RelB Inhibition in the Context of Neuroinflammatory Diseases

Rashida Ginwala et al.

Summary: Apigenin reduces EAE severity by shifting T cell responses from T(h)1 and T(h)17 to T(reg) type through modulation of DC activity. This is achieved by decreasing T-bet, IFN-gamma (T(h)1), IL-17 (T(h)17) and increasing IL-10, TGF-beta, and FoxP3 (T-reg) expression.

JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2021)

Article Pharmacology & Pharmacy

Protective effects of apigenin on altered lipid peroxidation, inflammation, and antioxidant factors in methotrexate-induced hepatotoxicity

Mehdi Goudarzi et al.

Summary: The study demonstrated that apigenin can prevent methotrexate-induced hepatotoxicity by increasing antioxidant markers and reducing inflammatory factors.

NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY (2021)

Article Oncology

XPO1 inhibition synergizes with PARP1 inhibition in small cell lung cancer by targeting nuclear transport of FOXO3a

Jingya Wang et al.

Summary: Combining a PARP inhibitor with an XPO1 inhibitor significantly improves efficacy and tolerability in treating small cell lung cancer, restoring the balance and activity of FOXO3a. This dual inhibition provides a new therapeutic approach for SCLC, warranting further investigation in potential clinical trials.

CANCER LETTERS (2021)

Article Pharmacology & Pharmacy

Alleviation of the doxorubicin-induced nephrotoxicity by fasudil in vivo and in vitro

Chengyu Xiang et al.

Summary: The study demonstrates that fasudil has a protective effect on doxorubicin-induced nephrotoxicity by inhibiting oxidative stress, DNA damage, apoptosis, and cell senescence through targeting the RhoA/Rho kinase (ROCK) signaling pathway.

JOURNAL OF PHARMACOLOGICAL SCIENCES (2021)

Article Cell Biology

Mangiferin prevents myocardial infarction-induced apoptosis and heart failure in mice by activating the Sirt1/FoxO3a pathway

Lingli Chen et al.

Summary: Mangiferin prevents cardiomyocyte apoptosis and subsequent heart failure in myocardial infarction by activating the Sirt1/FoxO3a pathway, showing potential in future clinical evaluation studies.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2021)

Article Medicine, Research & Experimental

Apigenin Alleviates Liver Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Autophagy via TGF-β1/Smad3 and p38/PPARα Pathways

Jie Ji et al.

Summary: The study confirmed that apigenin can reduce liver enzymes, suppress ECM generation, inhibit HSC activation, regulate MMP2 and TIMP1 balance, decrease autophagy protein expression, and restrain the TGF-beta 1/Smad3 and p38/PPAR alpha pathways, ultimately alleviating liver fibrosis.

PPAR RESEARCH (2021)

Article Cell & Tissue Engineering

MiR-34a inhibitor protects mesenchymal stem cells from hyperglycaemic injury through the activation of the SIRT1/FoxO3a autophagy pathway

Fengyun Zhang et al.

Summary: This study found that miR-34a is significantly increased under chronic hyperglycemia exposure, leading to impaired MSCs viability, exacerbated senescence, and disrupted paracrine capacity. The mechanism involves the activation of the SIRT1/FoxO3a autophagy pathway by miR-34a in MSCs exposed to high glucose, resulting in deterioration of cell function. Inhibiting miR-34a may hold therapeutic promise for MSC-based therapies in diabetic patients with myocardial infarction.

STEM CELL RESEARCH & THERAPY (2021)

Article Medicine, Research & Experimental

Apigenin ameliorates doxorubicin-induced renal injury via inhibition of oxidative stress and inflammation

Qijing Wu et al.

Summary: Apigenin has a protective role against DOX-induced nephrotoxicity without compromising its cytotoxicity in malignant tumors. It may serve as a potential protective agent against renal injury and inflammatory diseases, offering promise in attenuating renal toxicity in cancer patients undergoing DOX treatment.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Article Cell Biology

PNPLA3 I148M mediates the regulatory effect of NF-kB on inflammation in PA-treated HepG2 cells

Shuhua Yuan et al.

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2020)

Review Pharmacology & Pharmacy

Mesoporous Silica Nanoparticles as Carriers for Therapeutic Biomolecules

Rafael R. Castillo et al.

PHARMACEUTICS (2020)

Article Food Science & Technology

Aucubin administered by either oral or parenteral route protects against cisplatin-induced acute kidney injury in mice

Iva Potacnjak et al.

FOOD AND CHEMICAL TOXICOLOGY (2020)

Review Chemistry, Physical

Mesoporous Silica Nanoparticles in Bioimaging

Daohe Yuan et al.

MATERIALS (2020)

Review Pharmacology & Pharmacy

Mesoporous Silica Nanoparticles as Theranostic Antitumoral Nanomedicines

Alejandro Baeza et al.

PHARMACEUTICS (2020)

Review Biochemistry & Molecular Biology

The Therapeutic Potential of Apigenin

Bahare Salehi et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

Article Medicine, Research & Experimental

Calycosin Ameliorates Diabetes-Induced Renal Inflammation via the NF-κB Pathway In Vitro and In Vivo

Ying-ying Zhang et al.

MEDICAL SCIENCE MONITOR (2019)

Article Biochemistry & Molecular Biology

Obacunone attenuates high glucose-induced oxidative damage in NRK-52E cells by inhibiting the activity of GSK-3β

Jie Zhou et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Article Biochemistry & Molecular Biology

BH3 mimetic ABT-263 enhances the anticancer effects of apigenin in tumor cells with activating EGFR mutation

Yihong Zhan et al.

CELL AND BIOSCIENCE (2019)

Review Biochemistry & Molecular Biology

Drug-Induced Nephrotoxicity: Pathogenic Mechanisms, Biomarkers and Prevention Strategies

Huizi Wu et al.

CURRENT DRUG METABOLISM (2018)

Article Plant Sciences

Protective effects of apigenin and myricetin against cisplatin-induced nephrotoxicity in mice

Samar M. Hassana et al.

PHARMACEUTICAL BIOLOGY (2017)

Article Nanoscience & Nanotechnology

Molecular Elucidation of Biological Response to Mesoporous Silica Nanoparticles in Vitro and in Vivo

Cheng-Chung Chou et al.

ACS APPLIED MATERIALS & INTERFACES (2017)

Editorial Material Biotechnology & Applied Microbiology

Nanomedicine for targeted photothermal cancer therapy: where are we now?

Feng Chen et al.

NANOMEDICINE (2015)

Article Physiology

Acute reactive oxygen species (ROS)-dependent effects of IL-1β, TNF-α, and IL-6 on the glomerular filtration barrier (GFB) in vivo

Kristinn Sverrisson et al.

AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY (2015)

Article Cell Biology

GADD45γ regulates TNF-α and IL-6 synthesis in THP-1 cells

Gyu-Tae Shin et al.

INFLAMMATION RESEARCH (2012)