4.3 Article

The Ang III/AT2R Pathway Enhances Glucose Uptake by Improving GLUT1 Expression in 3T3-L1 Adipocytes

Journal

BIOLOGICAL & PHARMACEUTICAL BULLETIN
Volume 44, Issue 7, Pages 1014-1018

Publisher

PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/bpb.b20-00946

Keywords

angiotensin III; angiotensin II type 2 receptor; glucose transporter type 1; adipocyte

Funding

  1. Ministry of Education, Science, Sports, and Culture of Japan [18790067, 19590077]
  2. Showa University Research Grant for Young Researchers
  3. Grants-in-Aid for Scientific Research [19590077, 18790067] Funding Source: KAKEN

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The study revealed that Ang III enhances glucose uptake via upregulating GLUT1 expression through AT2R, while AT1R is not involved in this regulatory process.
Angiotensin III (Ang III) is a heptapeptide derived from Ang II that has been confirmed as the preferred agonist of angiotensin II type 2 receptor (AT2R). Recent studies have revealed AT2R mainly exerts anti-inflammation effects. However, the effects of the Ang III/AT2R pathway on adipocytes remain unknown. Here, the effects of Ang III on glucose uptake were examined. The results showed that AT2R expression was upregulated during adipogenesis in 3T3-L1 preadipocytes, whereas AT1R expression was diminished. Also, Ang III (10 nM) significantly increased glucose uptake by 3T3-L1 adipocytes, which was blocked by PD123319, an AT2R blocker, but not by irbesartan, an AT1R blocker. Ang III also induced the expression of glucose transporter type 1 (GLUT1). These stimulatory effects were inhibited by pretreatment with PD123319, but not with irbesartan. Together, these results indicate that Ang III enhances glucose uptake by upregulating GLUT1 expression via AT2R.

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