TPWshiny: an interactive R/Shiny app to explore cell line transcriptional responses to anti-cancer drugs

A Summary: The NCI Transcriptional Pharmacodynamics Workbench (NCI TPW) is an extensive compilation of directly measured transcriptional responses to anti-cancer agents across the well-characterized NCI-60 cancer cell lines. The NCI TPW data are publicly available through a web interface that allows limited user interaction with the data. We developed `TPWshiny' as a standalone, easy to install, R application to facilitate more interactive data exploration. With no programming skills required, TPWshiny provides an intuitive and comprehensive graphical interface to help researchers understand the response of tumor cell lines to 15 therapeutic agents. The data are presented in interactive scatter plots, heatmaps, time series and Venn diagrams. Data can be queried by drug concentration, time point, gene and tissue type. Researchers can download the data for further analysis.

Automated summary

The NCI TPW is a compilation of transcriptional responses to anti-cancer agents in the NCI-60 cancer cell lines, with data accessible through a web interface. TPWshiny is a standalone R application developed to provide an intuitive and comprehensive graphical interface for interactive data exploration, allowing researchers to understand how tumor cell lines respond to therapeutic agents.