Electrochemical sensing technology for liquid biopsy of circulating tumor cells-a review

In recent years, a lot of new detection techniques for circulating tumor cells (CTCs) have been developed. Among them, electrochemical sensing technology has gradually developed because of its advantages of good selectivity, high sensitivity, low cost and rapid detection. Especially in the latest decade, the field of electrochemical biosensing has witnessed great progress, thanks to the merging of biosensing research area with nanotechnology, immunotechnology, nucleic acid technology, and microfluidic technology. In this review, the recent progress for the detection of CTCs according to the principle of detection was sum-marized and how they can contribute to the enhanced performance of such biosensors was explained. The latest electrode construction strategies such as rolling circle amplification reaction, DNA walker and microfluidic technology and their advantages were also introduced emphatically. Moreover, the main reasons why the existing biosensors have not been widely used clinically and the next research points were clearly put forward. (c) 2021 Elsevier B.V. All rights reserved.

Automated summary

Recent years have seen significant advances in electrochemical sensing technology for the detection of CTCs, particularly with the merging of biosensing research area with other technologies. The latest electrode construction strategies and their advantages were highlighted, along with the main reasons for the limited clinical application of existing biosensors and future research directions.