4.6 Review

GRAMD1-mediated accessible cholesterol sensing and transport

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms

Xu Xiao et al.

Summary: Aster proteins mediate nonvesicular plasma membrane to endoplasmic reticulum cholesterol transport, with 20 alpha-hydroxycholesterol and U18666A identified as potential small molecule modulators. However, they target other sterol homeostatic proteins, limiting their utility.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

Article Biochemistry & Molecular Biology

Molecular basis of accessible plasma membrane cholesterol recognition by the GRAM domain of GRAMD1b

Bilge Ercan et al.

Summary: The GRAM domain of GRAMD1b plays a crucial role in detecting cholesterol and anionic lipids, with mutations potentially leading to intellectual disabilities in humans. Cell utilize the GRAM domain to regulate the rate of cholesterol transport and membrane tethering.

EMBO JOURNAL (2021)

Review Cell Biology

Mechanisms of nonvesicular lipid transport

Karin M. Reinisch et al.

Summary: Lipids can be transported between cellular membranes via nonvesicular mechanisms, supporting biogenesis of rapidly expanding membranes or allowing targeted modulation of specific lipid levels. Nonvesicular transport likely occurs at membrane contact sites and involves lipid transport proteins, but many questions remain unanswered regarding the mechanisms involved.

JOURNAL OF CELL BIOLOGY (2021)

Review Cell Biology

Mechanisms and regulation of cholesterol homeostasis

Jie Luo et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

Aster-C coordinates with COP I vesicles to regulate lysosomal trafficking and activation of mTORC1

Jun Zhang et al.

EMBO REPORTS (2020)

Article Biochemistry & Molecular Biology

Aster Proteins Regulate the Accessible Cholesterol Pool in the Plasma Membrane

Alessandra Ferrari et al.

MOLECULAR AND CELLULAR BIOLOGY (2020)

Article Multidisciplinary Sciences

Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Michael N. Trinh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)

Review Biochemistry & Molecular Biology

Structural and functional consequences of reversible lipid asymmetry in living membranes

Milka Doktorova et al.

NATURE CHEMICAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

StarD5: an ER stress protein regulates plasma membrane and intracellular cholesterol homeostasis

Daniel Rodriguez-Agudo et al.

JOURNAL OF LIPID RESEARCH (2019)

Article Biochemistry & Molecular Biology

The cholesterol transfer protein GRAMD1A regulates autophagosome biogenesis

Luca Laraia et al.

NATURE CHEMICAL BIOLOGY (2019)

Article Multidisciplinary Sciences

NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

D. Hoglinger et al.

NATURE COMMUNICATIONS (2019)

Review Cell Biology

Lipid transfer proteins: the lipid commute via shuttles, bridges and tubes

Louise H. Wong et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2019)

Review Biochemistry & Molecular Biology

Intracellular Cholesterol Transport by Sterol Transfer Proteins at Membrane Contact Sites

Jie Luo et al.

TRENDS IN BIOCHEMICAL SCIENCES (2019)

Article Biochemistry & Molecular Biology

Molecular basis for sterol transport by StART-like lipid transfer domains

Florian A. Horenkamp et al.

EMBO JOURNAL (2018)

Article Biochemistry & Molecular Biology

Structural basis of sterol binding and transport by a yeast StARkin domain

Julian-Alexander Jentsch et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Multidisciplinary Sciences

Structural basis of sterol recognition and nonvesicular transport by lipid transfer proteins anchored at membrane contact sites

Junsen Tong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2018)

Review Biochemistry & Molecular Biology

Retrospective on Cholesterol Homeostasis: The Central Role of Scap

Michael S. Brown et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Review Biochemistry & Molecular Biology

The Oxysterol-Binding Protein Cycle: Burning Off PI(4)P to Transport Cholesterol

Bruno Antonny et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 87 (2018)

Article Cell Biology

Sterol transporters at membrane contact sites regulate TORC1 and TORC2 signaling

Andrew Murley et al.

JOURNAL OF CELL BIOLOGY (2017)

Article Multidisciplinary Sciences

Mechanistic insight into the nucleus-vacuole junction based on the Vac8p-Nvj1p crystal structure

Hanbin Jeong et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)

Review Biochemistry & Molecular Biology

A Century of Cholesterol and Coronaries: From Plaques to Genes to Statins

Joseph L. Goldstein et al.

Article Cell Biology

Lam6 Regulates the Extent of Contacts between Organelles

Yael Elbaz-Alon et al.

CELL REPORTS (2015)

Review Cell Biology

Phospholipid Synthesis and Transport in Mammalian Cells

Jean E. Vance

TRAFFIC (2015)

Review Biochemistry & Molecular Biology

START ships lipids across interorganelle space

Fabien Alpy et al.

BIOCHIMIE (2014)

Article Chemistry, Multidisciplinary

Lipid Organization of the Plasma Membrane

Helgi I. Ingolfsson et al.

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2014)

Article Multidisciplinary Sciences

A comparative encyclopedia of DNA elements in the mouse genome

Feng Yue et al.

NATURE (2014)

Article Multidisciplinary Sciences

Biological insights from 108 schizophrenia-associated genetic loci

Stephan Ripke et al.

NATURE (2014)

Review Endocrinology & Metabolism

The mammalian START domain protein family in lipid transport in health and disease

Barbara J. Clark

JOURNAL OF ENDOCRINOLOGY (2012)

Article Cell Biology

STARD4 abundance regulates sterol transport and sensing

Bruno Mesmin et al.

MOLECULAR BIOLOGY OF THE CELL (2011)

Review Biophysics

The Distribution and Function of Phosphatidylserine in Cellular Membranes

Peter A. Leventis et al.

ANNUAL REVIEW OF BIOPHYSICS, VOL 39 (2010)

Review Cell Biology

Mitochondrial protein import: from proteomics to functional mechanisms

Oliver Schmidt et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)

Review Cell Biology

Membrane recognition by phospholipid-binding domains

Mark A. Lemmon

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Cell Biology

Cellular cholesterol trafficking and compartmentalization

Elina Ikonen

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Review Cell Biology

Membrane lipids: where they are and how they behave

Gerrit van Meer et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)

Article Biochemistry & Molecular Biology

Sterol and lipid trafficking in mammalian cells

F. R. Maxfield et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2006)

Article Multidisciplinary Sciences

Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase

MJ Begley et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)

Review Biochemistry & Molecular Biology

Condensed complexes of cholesterol and phospholipids

HM McConnell et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2003)

Review Physiology

StAR protein and the regulation of steroid hormone biosynthesis

DM Stocco

ANNUAL REVIEW OF PHYSIOLOGY (2001)

Article Multidisciplinary Sciences

Dissecting the role of the Golgi complex and lipid rafts in biosynthetic transport of cholesterol to the cell surface

S Heino et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2000)

Article Biochemistry & Molecular Biology

Chemical activity of cholesterol in membranes

A Radhakrishnan et al.

BIOCHEMISTRY (2000)