Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 49, Issue 4, Pages 1675-1684Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20201004
Keywords
-
Categories
Funding
- NIH 4D Nucleome Program [1U54DK107977-01, 1UM1HG011585-01]
- EU H2020 Marie Curie ITN [813282]
- Einstein BIH Fellowship Award [EVF-BIH-2016-282]
- CINECA ISCRA [HP10CYFPS5, HP10CRTY8P]
- Regione Campania POR SATIN 2018-2020
- CINECA ISCRA grant [HP10CCZ4KN]
- Einstein BIH Fellowship Award (2019)
Ask authors/readers for more resources
The development of new experimental technologies has provided deeper insights into the three-dimensional organization of chromosomes inside the cell nucleus, with the complexity of chromatin architecture data being understood through theoretical approaches based on polymer physics. Recent advances in Polymer Physics, combined with numerical Molecular Dynamics simulation and Machine Learning based inference, have helped to capture important aspects of genome organization, including tissue-specific structural rearrangements, regulatory-linked architectural elements, and chromatin structural variability at the single-cell level.
The development of new experimental technologies is opening the way to a deeper investigation of the three-dimensional organization of chromosomes inside the cell nucleus. Genome architecture is linked to vital functional purposes, yet a full comprehension of the mechanisms behind DNA folding is still far from being accomplished. Theoretical approaches based on polymer physics have been employed to understand the complexity of chromatin architecture data and to unveil the basic mechanisms shaping its structure. Here, we review some recent advances in the field to discuss how Polymer Physics, combined with numerical Molecular Dynamics simulation and Machine Learning based inference, can capture important aspects of genome organization, including the description of tissue-specific structural rearrangements, the detection of novel, regulatory-linked architectural elements and the structural variability of chromatin at the single-cell level.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available