Circulating tumor cells as a promising target for individualized drug susceptibility tests in cancer therapy

Circulating tumor cells (CTCs) play a crucial role in metastasis and became an emerging topic in today's cancer research. In addition, the analysis of CTCs in liquid biopsies will be a valuable tool for prognosis prediction and real time therapy monitoring. The characterization of CTCs may open up a new field of treatment strategy to prevent metastasis or maintain a stable disease. In 2013, the first cell cultures of CTCs have been established in vitro. Additionally, functional studies have been successfully performed over the last years. Meanwhile, more than 300 short-term CTC cultures and 42 long-term CTC cultures from a variety of tumor entities have been described. More than 45 inhibitors have already been tested for their efficacy to target CTCs in several studies in vitro as well as in xenograft mouse models in vivo. Here, we summarize the currently available data of these inhibition experiments and their effects in targeting CTCs. The results suggest that CTCs may be useful for individualized drug susceptibility testing.

Automated summary

CTCs play a crucial role in cancer metastasis and their analysis in liquid biopsies can be valuable for prognosis prediction and real-time therapy monitoring. Research on CTCs may lead to new treatment strategies for preventing metastasis or maintaining stable diseases. Studies on inhibitors targeting CTCs have shown promising results, suggesting CTCs may be useful for personalized drug susceptibility testing.