Journal
BIOCHEMICAL ENGINEERING JOURNAL
Volume 176, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bej.2021.108193
Keywords
Furfural; Furoic acid; Gluconobacter oxydans; Whole-cell catalysis; Co-recycling; Techno-economic analysis
Funding
- National Natural Science Foundation of China [31370573]
- Forestry Engineering First-class Discipline Construction Project of Nanjing Forestry University
- ECO Zhuoxin Energy-saving Technology (Shanghai) Company Limited
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The study focused on the biocatalysis of Gluconobacter oxydans for furfural oxidation to furoic acid and developed an integrated bioprocess for the co-recycling of cells and waste fermented broth. Sorbitol played a critical role in the co-recycling process, and yeast extract cost was substituted entirely by cheaper corn extract. The furoic acid bioproduction efficiency remained high with 10.3 g/L/h productivity and 98% yield, providing a novel idea for biotechnology developments in toxic furans bioconversion and industrial fermentation.
Furoic acid (FA) is used widely as raw material for bio-based resin, food, pharmaceutical and perfume products. The biocatalysis of Gluconobacter oxydans is on the spotlight of furfural oxidation to FA because of high selectivity, safety and environmental friendliness. However, like most bacterial fermentations, we have to treat a lot of waste fermented broth, especially containing toxic furans. An integrated bioprocess was developed to achieve the co-recycling of cells and waste broth during FA bioproduction. We found sorbitol performed a critical role during the co-recycling biopmcess and the cost of yeast extract was substituted entirely by cheaper corn extract. Here, FA biopmduction efficiency kept six rounds with the productivity of 10.3 g/L/h and 98% yield. The integrated biopmcess provides a novel idea for biotechnology developments not only on bioconversion of toxic furans but also on industrial fermentation, especially for the troublesome problems around the recycling of waste fermented broth.
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