4.6 Article

SMG9 drives ferroptosis by directly inhibiting GPX4 degradation

Related references

Note: Only part of the references are listed.
Editorial Material Biotechnology & Applied Microbiology

ESCRT-III-mediated membrane repair in cell death and tumor resistance

Jiao Liu et al.

Summary: The plasma membrane acts as a barrier and gatekeeper under physiological conditions to protect cells, but undergoes structural and functional changes in pathological situations leading to cell damage. ESCRT-III plays a key role in repairing damaged plasma membranes during various types of regulated cell death, suggesting it as a potential target for overcoming drug resistance in tumor therapy.

CANCER GENE THERAPY (2021)

Review Genetics & Heredity

The Branched Nature of the Nonsense-Mediated mRNA Decay Pathway

Zhongxia Yi et al.

Summary: Nonsense-mediated mRNA decay (NMD) is a conserved translation-coupled quality control mechanism in all eukaryotes, especially crucial in vertebrates. In vertebrates, NMD is a complex, branched pathway that regulates specific mRNA subsets to fulfill distinct physiological functions.

TRENDS IN GENETICS (2021)

Review Biochemistry & Molecular Biology

Cellular degradation systems in ferroptosis

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent oxidative cell death driven by lipid peroxidation. Various antioxidant systems play a significant role in preventing ferroptotic death. The cellular degradation systems play a dual role in regulating the ferroptotic response.

CELL DEATH AND DIFFERENTIATION (2021)

Review Cell Biology

Ferroptosis: molecular mechanisms and health implications

Daolin Tang et al.

Summary: Cell death can be executed through different subroutines, such as ferroptosis which is an iron-dependent form of non-apoptotic cell death. Ferroptosis can occur through two major pathways, driven by redox imbalance and abnormal expression of redox-active enzymes. The process is precisely regulated at multiple levels, with the transcription factor NFE2L2 playing a central role in anti-ferroptotic defense.

CELL RESEARCH (2021)

Review Oncology

Broadening horizons: the role of ferroptosis in cancer

Xin Chen et al.

Summary: Ferroptosis is an iron-dependent form of regulated cell death driven by excessive lipid peroxidation, and can be induced by various agents to suppress tumor growth while also potentially triggering inflammation-associated immunosuppression. The extent of ferroptosis's impact on tumor biology and its interactions with other signaling pathways are still under investigation.

NATURE REVIEWS CLINICAL ONCOLOGY (2021)

Article Multidisciplinary Sciences

NUPR1 is a critical repressor of ferroptosis

Jiao Liu et al.

Summary: Ferroptosis is a type of iron-dependent regulated cell death, and the stress-inducible transcription factor NUPR1 may drive resistance to ferroptosis by mediating LCN2 expression. Blocking the NUPR1-LCN2 pathway can increase ferroptosis inducer activity and worsen conditions like pancreatitis in relevant mouse models.

NATURE COMMUNICATIONS (2021)

Article Multidisciplinary Sciences

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Chao Mao et al.

Summary: The study reveals the mechanism of ferroptosis induced by inhibiting GPX4 in cancer cells, as well as the potential pathways to enhance or inhibit ferroptosis by intervening in relevant metabolic pathways. Therapeutic strategies targeting different levels of GPX4 expression could be a promising new approach for cancer treatment.

NATURE (2021)

Article Biochemistry & Molecular Biology

ESCRT-III-dependent membrane repair blocks ferroptosis

Enyong Dai et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Article Biochemistry & Molecular Biology

Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells

Hai Wang et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)

Review Cell Biology

Emerging Mechanisms and Disease Relevance of Ferroptosis

Brent R. Stockwell et al.

TRENDS IN CELL BIOLOGY (2020)

Article Multidisciplinary Sciences

Nonsense-mediated mRNA decay factor UPF1 promotes aggresome formation

Yeonkyoung Park et al.

NATURE COMMUNICATIONS (2020)

Review Oncology

Ferroptosis in Cancer Treatment: Another Way to Rome

Yinan Wu et al.

FRONTIERS IN ONCOLOGY (2020)

Review Cell Biology

Oxidative Damage and Antioxidant Defense in Ferroptosis

Feimei Kuang et al.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2020)

Article Biochemistry & Molecular Biology

The release and activity of HMGB1 in ferroptosis

Qirong Wen et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)

Review Cell Biology

The molecular machinery of regulated cell death

Daolin Tang et al.

CELL RESEARCH (2019)

Article Biochemistry & Molecular Biology

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Sebastian Doll et al.

NATURE CHEMICAL BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Stress and the nonsense-mediated RNA decay pathway

Alexandra E. Goetz et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2017)

Article Biochemistry & Molecular Biology

Identification of ACSL4 as a biomarker and contributor of ferroptosis

Hua Yuan et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)

Article Biochemistry & Molecular Biology

Caspases shutdown nonsense-mediated mRNA decay during apoptosis

J. Jia et al.

CELL DEATH AND DIFFERENTIATION (2015)

Article Multidisciplinary Sciences

Attenuation of nonsense-mediated mRNA decay facilitates the response to chemotherapeutics

Maximilian W. Popp et al.

NATURE COMMUNICATIONS (2015)

Article Biochemistry & Molecular Biology

Regulation of Ferroptotic Cancer Cell Death by GPX4

Wan Seok Yang et al.

Article Biochemistry & Molecular Biology

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Scott J. Dixon et al.

Article Biochemistry & Molecular Biology

Role of reactive oxygen species (ROS) in apoptosis induction

HU Simon et al.

APOPTOSIS (2000)