Journal
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volume 560, Issue -, Pages 146-151Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2021.04.132
Keywords
Mitochondria; Dendrite; Axon; Synapse; Development
Categories
Funding
- [180231]
- [180538]
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The study found that TND1128 can promote morphological growth of mouse hippocampal neurons, increase the number of excitatory synapses, and provide a new drug treatment approach for improving brain function.
Adenosine triphosphate (ATP) is the most vital energy source produced mainly in the mitochondria. Age-related mitochondrial dysfunction is associated with brain diseases. Nicotinamide adenine dinucleotide (NAD(+)) is an essential cofactor for energy production in mitochondria. Here, we examined how the novel NAD(+)-assisting substance, 10-ethyl-3-methylpyrimido[4,5-b]quinoline-2,4(3H,10H)-dione (TND1128), modulates the morphological growth of cultured mouse hippocampal neurons. The morphological growth effect of TND1128 was also compared with that of beta-nicotinamide mononucleotide (beta-NMN). TND1128 induced the branching of axons and dendrites, and increased the number of excitatory synapses. This study provides new insight into TND1128 as a mitochondria-stimulating drug for improving brain function. (C) 2021 Elsevier Inc. All rights reserved.
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