Recent advances in the tandem annulation of 1,3-enynes to functionalized pyridine and pyrrole derivatives

Great progress has been made in the tandem annulation of enynes in the past few years. This review only presents the correspond-ing reactions of 1,3-enyne structural motifs to provide the functionalized pyridine and pyrrole derivatives. The functionalization reactions cover iodination, bromination, trifluoromethylation, azidation, carbonylation, arylation, alkylation, selenylation, sulfenyla-tion, amidation, esterification, and hydroxylation. We also briefly introduce the applications of the products and the reaction mecha-nisms for the synthesis of corresponding N-heterocycles.

Automated summary

Significant progress has been made in the tandem annulation of enynes in recent years, mainly focusing on the corresponding reactions of 1,3-enyne structural motifs to provide functionalized pyridine and pyrrole derivatives. These functionalization reactions involve various methods of introducing functional groups, facilitating the synthesis of N-heterocycles.