Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 413, Issue -, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2021.113460
Keywords
Anxiolitic-like behavior; Rats; Magnesium; Anxiogenic; Veratrin; Diazepam
Categories
Funding
- CONACYT [A1S14473, 428833]
- Beltran-Morgado Foundation for the Advancement and Communication of Neuroscience in Veracruz
Ask authors/readers for more resources
Magnesium dietary supplementation can significantly reduce anxiety levels in rats, increase the concentration of magnesium in plasma and cerebrospinal fluid, but the anxiolytic effect washes out within 12 days.
Evidence suggest that magnesium dietary supplementation has several health benefits including lowering blood pressure, reducing insulin resistance, and improving symptoms of depression, anxiety, and migraine. Here, we aimed to study the effect of chronic magnesium supplementation on anxiety-like behavior in rats by supplementing with magnesium their drinking water for 30 days. Anxiety-like behavior was induced by subcutaneous injection of veratrin 30 min before performing elevated plus maze and open field tests to measure anxiety levels and locomotion, respectively. We quantify the concentration of magnesium in plasma and cerebrospinal fluid. We used diazepam to compare the efficacy of magnesium supplementation as an anxiolytic agent. Our results show that rats supplemented with magnesium had a statistically significant decrease in anxiety levels with not effects on locomotion and a statistically significant increase in concentration of magnesium in plasma and cerebrospinal fluid. However, the anxiolytic effect of magnesium supplementation washes-out in 12 days. We discuss the advantages of using supplemental magnesium as anxiolytic.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available