4.5 Review

Molecular and cellular pathways contributing to brain aging

Related references

Note: Only part of the references are listed.
Review Pharmacology & Pharmacy

Targeting autophagy-related protein kinases for potential therapeutic purpose

Honggang Xiang et al.

ACTA PHARMACEUTICA SINICA B (2020)

Review Biochemistry & Molecular Biology

Calorie Restriction and Aging in Humans

Emily W. Flanagan et al.

ANNUAL REVIEW OF NUTRITION, VOL 40, 2020 (2020)

Article Cell Biology

Thymoquinone-induced antitumor and apoptosis in human lung adenocarcinoma cells

Saeed Samarghandian et al.

JOURNAL OF CELLULAR PHYSIOLOGY (2019)

Article Neuroimaging

Increased brain age in adults with Prader-Willi syndrome

Adriana M. Azor et al.

NEUROIMAGE-CLINICAL (2019)

Editorial Material Pharmacology & Pharmacy

The Neuroprotective Effects of Thymoquinone: A Review

Tahereh Farkhondeh et al.

DOSE-RESPONSE (2018)

Review Neurosciences

Astroglial Glutamate Signaling and Uptake in the Hippocampus

Christine R. Rose et al.

FRONTIERS IN MOLECULAR NEUROSCIENCE (2018)

Review Immunology

The Role of Mitophagy in Innate Immunity

Ilias Gkikas et al.

FRONTIERS IN IMMUNOLOGY (2018)

Editorial Material Cell Biology

Pink1/Parkin link inflammation, mitochondrial stress, and neurodegeneration

Laura E. Newman et al.

JOURNAL OF CELL BIOLOGY (2018)

Article Multidisciplinary Sciences

Disruption of the beclin 1-BCL2 autophagy regulatory complex promotes longevity in mice

Alvaro F. Fernandez et al.

NATURE (2018)

Review Biochemistry & Molecular Biology

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

Sophia M. Raefsky et al.

FREE RADICAL BIOLOGY AND MEDICINE (2017)

Review Biochemistry & Molecular Biology

NAD+ in Aging: Molecular Mechanisms and Translational Implications

Evandro F. Fang et al.

TRENDS IN MOLECULAR MEDICINE (2017)

Review Biochemistry & Molecular Biology

Redox control of senescence and age-related disease

Akshaya Chandrasekaran et al.

REDOX BIOLOGY (2017)

Review Biochemistry & Molecular Biology

Brain metabolism in health, aging, and neurodegeneration

Simonetta Camandola et al.

EMBO JOURNAL (2017)

Review Biochemistry & Molecular Biology

Signaling Networks Determining Life Span

Celine E. Riera et al.

ANNUAL REVIEW OF BIOCHEMISTRY, VOL 85 (2016)

Review Cell Biology

From Ancient Pathways to Aging Cells-Connecting Metabolism and Cellular Senescence

Christopher D. Wiley et al.

CELL METABOLISM (2016)

Article Cell Biology

Mitochondrial ROS Produced via Reverse Electron Transport Extend Animal Lifespan

Filippo Scialo et al.

CELL METABOLISM (2016)

Review Endocrinology & Metabolism

The role of the p53 tumor suppressor in metabolism and diabetes

Che-Pei Kung et al.

JOURNAL OF ENDOCRINOLOGY (2016)

Article Neurosciences

Age-Related Changes in Axonal and Mitochondrial Ultrastructure and Function in White Matter

Katharine E. Stahon et al.

JOURNAL OF NEUROSCIENCE (2016)

Review Urology & Nephrology

Autophagy in kidney disease and aging: lessons from rodent models

Olivia Lenoir et al.

KIDNEY INTERNATIONAL (2016)

Review Cell Biology

Nuclear DNA damage signalling to mitochondria in ageing

Evandro Fei Fang et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2016)

Review Rheumatology

Ageing and the pathogenesis of osteoarthritis

Richard F. Loeser et al.

NATURE REVIEWS RHEUMATOLOGY (2016)

Article Biochemistry & Molecular Biology

Brain cortex mitochondrial bioenergetics in synaptosomes and non-synaptic mitochondria during aging

Silvia Lores-Arnaiz et al.

NEUROCHEMICAL RESEARCH (2016)

Article Chemistry, Medicinal

Effect of crocin on aged rat kidney through inhibition of oxidative stress and proinflammatory state

Saeed Samarghandian et al.

PHYTOTHERAPY RESEARCH (2016)

Review Geriatrics & Gerontology

Lifespan-regulating genes in C. elegans

Masaharu Uno et al.

NPJ AGING AND MECHANISMS OF DISEASE (2016)

Review Oncology

Emerging therapeutic roles for NAD+ metabolism in mitochondrial and age-related disorders

Sarika Srivastava

CLINICAL AND TRANSLATIONAL MEDICINE (2016)

Article Biochemistry & Molecular Biology

Age-related changes in the proteostasis network in the brain of the naked mole-rat: Implications promoting healthy longevity

Judy C. Triplett et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2015)

Review Biochemistry & Molecular Biology

Mitochondrial quality control pathways as determinants of metabolic health

Ntsiki M. Held et al.

BIOESSAYS (2015)

Review Oncology

Tumor suppressor p53 and its mutants in cancer metabolism

Juan Liu et al.

CANCER LETTERS (2015)

Article Cell Biology

AMPK: positive and negative regulation, and its role in whole-body energy homeostasis

D. Grahame Hardie

CURRENT OPINION IN CELL BIOLOGY (2015)

Article Geriatrics & Gerontology

Aberrant mTOR activation in senescence and aging: A mitochondrial stress response?

Timothy Nacarelli et al.

EXPERIMENTAL GERONTOLOGY (2015)

Review Endocrinology & Metabolism

Macronutrients and caloric intake in health and longevity

Samantha M. Solon-Biet et al.

JOURNAL OF ENDOCRINOLOGY (2015)

Article Geriatrics & Gerontology

Reconsidering the Role of Mitochondria in Aging

Marta Gonzalez-Freire et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2015)

Article Neurosciences

Mutations in LRRK2 potentiate age-related impairment of autophagic flux

Shamol Saha et al.

MOLECULAR NEURODEGENERATION (2015)

Review Cell Biology

p53 in survival, death and metabolic health: a lifeguard with a licence to kill

Flore Kruiswijk et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Review Cell Biology

Autophagy at the crossroads of catabolism and anabolism

Jasvinder Kaur et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2015)

Review Neurosciences

Compromised autophagy and neurodegenerative diseases

Fiona M. Menzies et al.

NATURE REVIEWS NEUROSCIENCE (2015)

Review Multidisciplinary Sciences

Human telomere biology: A contributory and interactive factor in aging, disease risks, and protection

Elizabeth H. Blackburn et al.

SCIENCE (2015)

Review Geriatrics & Gerontology

Microglial cell dysregulation in brain aging and neurodegeneration

Rommy von Bernhardi et al.

FRONTIERS IN AGING NEUROSCIENCE (2015)

Article Genetics & Heredity

Mitochondrial and Cytoplasmic ROS Have Opposing Effects on Lifespan

Claire E. Schaar et al.

PLOS GENETICS (2015)

Review Biochemistry & Molecular Biology

Redox regulation of FoxO transcription factors

Lars-Oliver Klotz et al.

REDOX BIOLOGY (2015)

Review Geriatrics & Gerontology

Physical exercise and vascular endothelial growth factor (VEGF) in elderly: A systematic review

Thays Martins Vital et al.

ARCHIVES OF GERONTOLOGY AND GERIATRICS (2014)

Review Pharmacology & Pharmacy

Microglial dysfunction in brain aging and Alzheimer's disease

Kira Irving Mosher et al.

BIOCHEMICAL PHARMACOLOGY (2014)

Review Cell Biology

Mitohormesis

Jeanho Yun et al.

CELL METABOLISM (2014)

Review Cell Biology

Autophagy regulation by nutrient signaling

Ryan C. Russell et al.

CELL RESEARCH (2014)

Review Biochemistry & Molecular Biology

Senescence and apoptosis: dueling or complementary cell fates?

Bennett G. Childs et al.

EMBO REPORTS (2014)

Article Geriatrics & Gerontology

Reversal of Age-Related Learning Deficiency by the Vertebrate PACAP and IGF-1 in a Novel Invertebrate Model of Aging: The Pond Snail (Lymnaea stagnalis)

Zsolt Pirger et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

Article Geriatrics & Gerontology

Endothelin-1-Induced Focal Cerebral Ischemia in the Growth Hormone/IGF-1 Deficient Lewis Dwarf Rat

Han Yan et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2014)

Review Neurosciences

Roles for NF-κB and Gene Targets of NF-κB in Synaptic Plasticity, Memory, and Navigation

Wanda M. Snow et al.

MOLECULAR NEUROBIOLOGY (2014)

Review Multidisciplinary Sciences

Mitochondrial form and function

Jonathan R. Friedman et al.

NATURE (2014)

Review Endocrinology & Metabolism

Autophagy-a key player in cellular and body metabolism

Kook Hwan Kim et al.

NATURE REVIEWS ENDOCRINOLOGY (2014)

Review Cell Biology

Mitochondrial dynamics and inheritance during cell division, development and disease

Prashant Mishra et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2014)

Article Geriatrics & Gerontology

Priming of microglia in a DNA-repair deficient model of accelerated aging

Divya D. A. Raj et al.

NEUROBIOLOGY OF AGING (2014)

Article Clinical Neurology

Imaging and Cognitive Reserve Studies Predict Dementia in Presymptomatic Alzhekimer's Disease Subjects

Camilla Ferrari et al.

NEURODEGENERATIVE DISEASES (2014)

Review Biochemistry & Molecular Biology

FOXO transcription factors: key regulators of cellular quality control

Ashley E. Webb et al.

TRENDS IN BIOCHEMICAL SCIENCES (2014)

Review Biotechnology & Applied Microbiology

Biology of Ageing and Role of Dietary Antioxidants

Cheng Peng et al.

BIOMED RESEARCH INTERNATIONAL (2014)

Article Cell Biology

Balance between autophagic pathways preserves retinal homeostasis

Natalia Rodriguez-Muela et al.

AGING CELL (2013)

Review Biochemistry & Molecular Biology

Mitochondrial DNA Oxidative Damage and Repair in Aging and Alzheimer's Disease

Renato X. Santos et al.

ANTIOXIDANTS & REDOX SIGNALING (2013)

Review Biochemistry & Molecular Biology

The Hallmarks of Aging

Carlos Lopez-Otin et al.

Review Cell Biology

Metabolic Regulation by p53 Family Members

Celia R. Berkers et al.

CELL METABOLISM (2013)

Review Cardiac & Cardiovascular Systems

Caloric Restriction IMPLICATIONS FOR HUMAN CARDIOMETABOLIC HEALTH

Connie W. Bales et al.

JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION (2013)

Review Medicine, Research & Experimental

The sirtuin family's role in aging and age-associated pathologies

Jessica A. Hall et al.

JOURNAL OF CLINICAL INVESTIGATION (2013)

Review Biotechnology & Applied Microbiology

Modulation of oxidative stress as an anticancer strategy

Chiara Gorrini et al.

NATURE REVIEWS DRUG DISCOVERY (2013)

Review Cell Biology

Finding the end: recruitment of telomerase to telomeres

Jayakrishnan Nandakumar et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)

Review Biochemistry & Molecular Biology

Senescence and aging: the critical roles of p53

A. Rufini et al.

ONCOGENE (2013)

Article Multidisciplinary Sciences

Metformin improves healthspan and lifespan in mice

Alejandro Martin-Montalvo et al.

NATURE COMMUNICATIONS (2013)

Review Geriatrics & Gerontology

Insulin-like growth factor-1 in CNS and cerebrovascular aging

William E. Sonntag et al.

FRONTIERS IN AGING NEUROSCIENCE (2013)

Article Cell Biology

Changes in neuronal DNA content variation in the human brain during aging

Hans-Georg Fischer et al.

AGING CELL (2012)

Review Physiology

Lysosomal Acidification Mechanisms

Joseph A. Mindell

ANNUAL REVIEW OF PHYSIOLOGY, VOL 74 (2012)

Review Biochemistry & Molecular Biology

Mitochondria: In Sickness and in Health

Jodi Nunnari et al.

Article Biochemistry & Molecular Biology

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

Susmita Kaushik et al.

EMBO REPORTS (2012)

Review Cardiac & Cardiovascular Systems

Nitric oxide synthases: regulation and function

Ulrich Foerstermann et al.

EUROPEAN HEART JOURNAL (2012)

Editorial Material Cell Biology

PINK1-and Parkin-mediated mitophagy at a glance

Seok Min Jin et al.

JOURNAL OF CELL SCIENCE (2012)

Article Geriatrics & Gerontology

Diverse Roles of Growth Hormone and Insulin-Like Growth Factor-1 in Mammalian Aging: Progress and Controversies

William E. Sonntag et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)

Article Geriatrics & Gerontology

Aging, Atherosclerosis, and IGF-1

Yusuke Higashi et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)

Article Geriatrics & Gerontology

Aging, Synaptic Dysfunction, and Insulin-Like Growth Factor (IGF)-1

Ferenc Deak et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2012)

Review Cell Biology

AMPK: a nutrient and energy sensor that maintains energy homeostasis

D. Grahame Hardie et al.

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2012)

Review Oncology

Mechanisms of telomere loss and their consequences for chromosome instability

Keiko Muraki et al.

FRONTIERS IN ONCOLOGY (2012)

Review Biochemistry & Molecular Biology

DAF-16/Forkhead Box O Transcription Factor: Many Paths to a Single Fork(head) in the Road

Kelvin Yen et al.

ANTIOXIDANTS & REDOX SIGNALING (2011)

Editorial Material Cell Biology

Chasing the elusive mammalian microautophagy

Laura Santambrogio et al.

AUTOPHAGY (2011)

Article Clinical Neurology

Telomere shortening reduces Alzheimer's disease amyloid pathology in mice

Harshvardhan Rolyan et al.

BRAIN (2011)

Review Biochemistry & Molecular Biology

Chaperone-mediated autophagy: machinery, regulation and biological consequences

Wenming Li et al.

CELLULAR AND MOLECULAR LIFE SCIENCES (2011)

Article Biochemistry & Molecular Biology

FoxO1 Mediates an Autofeedback Loop Regulating SIRT1 Expression

Shiqin Xiong et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Biochemistry & Molecular Biology

A New Cytosolic Pathway from a Parkinson Disease-associated Kinase, BRPK/PINK1 ACTIVATION OF AKT VIA MTORC2

Hitoshi Murata et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2011)

Article Medicine, General & Internal

Physical activity and risk of cognitive decline: a meta-analysis of prospective studies

F. Sofi et al.

JOURNAL OF INTERNAL MEDICINE (2011)

Article Multidisciplinary Sciences

Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice

Mariela Jaskelioff et al.

NATURE (2011)

Article Multidisciplinary Sciences

Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect

Cen Zhang et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Article Multidisciplinary Sciences

Exercise training increases size of hippocampus and improves memory

Kirk I. Erickson et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)

Review Neurosciences

Toll-like receptor signaling in neural plasticity and disease

Eitan Okun et al.

TRENDS IN NEUROSCIENCES (2011)

Article Oncology

Regulation of Autophagy by Kinases

Savitha Sridharan et al.

Cancers (2011)

Review Chemistry, Multidisciplinary

Caloric restriction and heart function: is there a sensible link?

Xuefeng Han et al.

ACTA PHARMACOLOGICA SINICA (2010)

Review Medicine, General & Internal

Systematic Review: Factors Associated With Risk for and Possible Prevention of Cognitive Decline in Later Life

Brenda L. Plassman et al.

ANNALS OF INTERNAL MEDICINE (2010)

Review Pathology

Mammalian Sirtuins: Biological Insights and Disease Relevance

Marcia C. Haigis et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2010)

Article Medicine, General & Internal

Physical Activity at Midlife in Relation to Successful Survival in Women at Age 70 Years or Older

Qi Sun et al.

ARCHIVES OF INTERNAL MEDICINE (2010)

Article Biochemistry & Molecular Biology

Decline in mitochondrial bioenergetics and shift to ketogenic profile in brain during reproductive senescence

Jia Yao et al.

BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2010)

Article Biochemistry & Molecular Biology

FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

Fabio Demontis et al.

Review Neurosciences

Neurogenesis and Alzheimer's disease: At the crossroads

Orly Lazarov et al.

EXPERIMENTAL NEUROLOGY (2010)

Review Biochemistry & Molecular Biology

mTOR regulation of autophagy

Chang Hwa Jung et al.

FEBS LETTERS (2010)

Review Geriatrics & Gerontology

Changes of telomere length with aging

Kaiyo Takubo et al.

GERIATRICS & GERONTOLOGY INTERNATIONAL (2010)

Article Neurosciences

Reactive Oxygen Species: Stuck in the Middle of Neurodegeneration

David A. Patten et al.

JOURNAL OF ALZHEIMERS DISEASE (2010)

Article Biochemistry & Molecular Biology

Phosphatidylinositol 3-Kinase Facilitates Microtubule-dependent Membrane Transport for Neuronal Growth Cone Guidance

Hiroki Akiyama et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2010)

Review Biochemistry & Molecular Biology

Autophagy and the Integrated Stress Response

Guido Kroemer et al.

MOLECULAR CELL (2010)

Article Neurosciences

EXERCISE AND TIME-DEPENDENT BENEFITS TO LEARNING AND MEMORY

N. C. Berchtold et al.

NEUROSCIENCE (2010)

Article Multidisciplinary Sciences

Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer's disease

Marta M. Lipinski et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Article Multidisciplinary Sciences

Running enhances spatial pattern separation in mice

David J. Creer et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)

Review Multidisciplinary Sciences

Autophagy and Metabolism

Joshua D. Rabinowitz et al.

SCIENCE (2010)

Editorial Material Cell Biology

The overexpression of major antioxidant enzymes does not extend the lifespan of mice

Viviana I. Perez et al.

AGING CELL (2009)

Article Biochemistry & Molecular Biology

Reduced IGF-1 Signaling Delays Age-Associated Proteotoxicity in Mice

Ehud Cohen et al.

Article Biochemistry & Molecular Biology

Hydrogen peroxide-induced neuronal apoptosis is associated with inhibition of protein phosphatase 2A and 5, leading to activation of MAPK pathway

Long Chen et al.

INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2009)

Review Medicine, General & Internal

Health benefits of physical activity in older patients: a review

T. Vogel et al.

INTERNATIONAL JOURNAL OF CLINICAL PRACTICE (2009)

Article Neurosciences

Chemically Inducible Inactivation of Protein Synthesis in Genetically Targeted Neurons

Hyun-Soo Je et al.

JOURNAL OF NEUROSCIENCE (2009)

Article Geriatrics & Gerontology

Mice Deficient in Both Mn Superoxide Dismutase and Glutathione Peroxidase-1 Have Increased Oxidative Damage and a Greater Incidence of Pathology but No Reduction in Longevity

Yiqiang Zhang et al.

JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2009)

Review Physiology

Transcription Factors in Long-Term Memory and Synaptic Plasticity

Cristina M. Alberini

PHYSIOLOGICAL REVIEWS (2009)

Article Genetics & Heredity

Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans

Jeremy M. Van Raamsdonk et al.

PLOS GENETICS (2009)

Review Oncology

p53 and metabolism

Karen H. Vousden et al.

NATURE REVIEWS CANCER (2009)

Review Cell Biology

Dietary factors, hormesis and health

Mark P. Mattson

AGEING RESEARCH REVIEWS (2008)

Review Pathology

The aging brain

Bruce A. Yankner et al.

ANNUAL REVIEW OF PATHOLOGY-MECHANISMS OF DISEASE (2008)

Review Neurosciences

Be smart, exercise your heart: exercise effects on brain and cognition

Charles H. Hillman et al.

NATURE REVIEWS NEUROSCIENCE (2008)

Review Neurosciences

Mitochondria in Neuroplasticity and Neurological Disorders

Mark P. Mattson et al.

NEURON (2008)

Article Endocrinology & Metabolism

Nox2-derived reactive oxygen species mediate neurovascular dysregulation in the aging mouse brain

Laibaik Park et al.

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM (2007)

Article Cell Biology

Reduced mitochondrial. SOD displays mortality characteristics reminiscent of natural aging

Anirban Paul et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2007)

Review Neurosciences

Microglia: active sensor and versatile effector cells in the normal and pathologic brain

Uwe-Karsten Hanisch et al.

NATURE NEUROSCIENCE (2007)

Article Clinical Neurology

Education and dementia - What lies behind the association?

T. Ngandu et al.

NEUROLOGY (2007)

Article Developmental Biology

PI3K/Akt and CREB regulate adult neural hippocampal progenitor proliferation and differentiation

Joseph Peltier et al.

DEVELOPMENTAL NEUROBIOLOGY (2007)

Article Neurosciences

Aneuploidy and DNA replication in the normal human brain and Alzheimer's disease

Birgit Mosch et al.

JOURNAL OF NEUROSCIENCE (2007)

Article Biochemistry & Molecular Biology

Selective degradation of mitochondria by mitophagy

Insil Kim et al.

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2007)

Article Developmental Biology

The influence of maternal treadmill running short-term memory and hippocampal cell during pregnancy on survival in rat pups

Hong Kim et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2007)

Review Biochemistry & Molecular Biology

Hydrogen peroxide sensing and signaling

Elizabeth A. Veal et al.

MOLECULAR CELL (2007)

Review Pharmacology & Pharmacy

Targeting mammalian target of rapamycin (mTOR) for health and diseases

Chi Kwan Tsang et al.

DRUG DISCOVERY TODAY (2007)

Review Neurosciences

Microglia-mediated neurotoxicity: uncovering the molecular mechanisms

Michelle L. Block et al.

NATURE REVIEWS NEUROSCIENCE (2007)

Review Oncology

Immunosenescence of ageing

A. L. Gruver et al.

JOURNAL OF PATHOLOGY (2007)

Article Geriatrics & Gerontology

Ca2+ signaling, mitochondria and sensitivity to oxidative stress in aging astrocytes

Da-Ting Lin et al.

NEUROBIOLOGY OF AGING (2007)

Article Cell Biology

Thinking globally and acting locally with TOR

Andrew M. Arsham et al.

CURRENT OPINION IN CELL BIOLOGY (2006)

Article Geriatrics & Gerontology

Physical exercise prevents age-related decline in precursor cell activity in the mouse dentate gyrus

Golo Kronenberg et al.

NEUROBIOLOGY OF AGING (2006)

Review Cell Biology

Caloric restriction and intermittent fasting: Two potential diets for successful brain aging

Bronwen Martin et al.

AGEING RESEARCH REVIEWS (2006)

Review Biochemistry & Molecular Biology

Mitochondria: More than just a powerhouse

Heidi M. McBride et al.

CURRENT BIOLOGY (2006)

Article Multidisciplinary Sciences

p53 regulates mitochondrial respiration

Satoaki Matoba et al.

SCIENCE (2006)

Article Multidisciplinary Sciences

Loss of autophagy in the central nervous system causes neurodegeneration in mice

Masaaki Komatsu et al.

NATURE (2006)

Review Psychology, Clinical

Brain reserve and dementia: a systematic review

MJ Valenzuela et al.

PSYCHOLOGICAL MEDICINE (2006)

Article Developmental Biology

Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms

M Sastre et al.

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2006)

Review Biochemistry & Molecular Biology

TOR signaling in growth and metabolism

S Wullschleger et al.

Review Biochemistry & Molecular Biology

TOR signaling in growth and metabolism

Stephan Wullschleger et al.

Review Neurosciences

Enriched environments, experience-dependent plasticity and disorders of the nervous system

Jess Nithianantharajah et al.

NATURE REVIEWS NEUROSCIENCE (2006)

Article Biochemistry & Molecular Biology

SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling

J Chen et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2005)

Review Biochemical Research Methods

Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview

E Mariani et al.

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)

Article Neurosciences

Exercise enhances learning and hippocampal neurogenesis in aged mice

H van Praag et al.

JOURNAL OF NEUROSCIENCE (2005)

Review Neurosciences

Microglia in health and disease

SU Kim et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2005)

Article Neurosciences

Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease

PA Adlard et al.

JOURNAL OF NEUROSCIENCE (2005)

Article Geriatrics & Gerontology

The exercise-induced expression of BDNF within the hippocampus varies across life-span

PA Adlard et al.

NEUROBIOLOGY OF AGING (2005)

Article Multidisciplinary Sciences

JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16

SW Oh et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)

Review Biochemistry & Molecular Biology

The plasticity of aging: Insights from long-lived mutants

C Kenyon

Article Oncology

The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression

F Schwartzenberg-Bar-Yoseph et al.

CANCER RESEARCH (2004)

Article Physiology

Circulating plasma VEGF response to exercise in sedentary and endurance-trained men

RM Kraus et al.

JOURNAL OF APPLIED PHYSIOLOGY (2004)

Review Neurosciences

LTP and LTD: An embarrassment of riches

RC Malenka et al.

NEURON (2004)

Review Cell Biology

Signaling to NF-κB

MS Hayden et al.

GENES & DEVELOPMENT (2004)

Article Biophysics

Brain region-specific, age-related, alterations in mitochondrial responses to elevated calcium

MR Brown et al.

JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2004)

Article Multidisciplinary Sciences

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

N Maswood et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Insulin-like growth factor I is required for vessel remodeling in the adult brain

C Lopez-Lopez et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Multidisciplinary Sciences

Sir2 mediates longevity in the fly through a pathway related to calorie restriction

B Rogina et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)

Article Biochemistry & Molecular Biology

Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase

F Yeung et al.

EMBO JOURNAL (2004)

Article Neurosciences

Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition

S Vaynman et al.

EUROPEAN JOURNAL OF NEUROSCIENCE (2004)

Review Cell Biology

The role of oxidative damage and stress in aging

A Bokov et al.

MECHANISMS OF AGEING AND DEVELOPMENT (2004)

Article Cell Biology

Additive regulation of hepatic gene expression by dwarfism and caloric restriction

T Tsuchiya et al.

PHYSIOLOGICAL GENOMICS (2004)

Article Medicine, General & Internal

Gene-diet interactions in brain aging and neurodegenerative disorders

MP Mattson

ANNALS OF INTERNAL MEDICINE (2003)

Article Neurosciences

Control of synaptic strength, a novel function of Akt

QH Wang et al.

NEURON (2003)

Article Endocrinology & Metabolism

Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16

M Imae et al.

JOURNAL OF MOLECULAR ENDOCRINOLOGY (2003)

Review Biochemistry & Molecular Biology

Glutathione pathways in the brain

R Dringen et al.

BIOLOGICAL CHEMISTRY (2003)

Article Multidisciplinary Sciences

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

WZ Duan et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)

Article Pharmacology & Pharmacy

From neurodegeneration to neurohomeostasis: The roles of ubliquitin

RJ Mayer

DRUG NEWS & PERSPECTIVES (2003)

Article Sport Sciences

Possible beneficial role of exercise in modulating low-grade inflammation in the elderly

BK Pedersen et al.

SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2003)

Article Biochemistry & Molecular Biology

Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity

RJ Mockett et al.

FREE RADICAL BIOLOGY AND MEDICINE (2003)

Article Biochemistry & Molecular Biology

Age-associated changes in central nervous system glycerolipid composition and metabolism

NM Giusto et al.

NEUROCHEMICAL RESEARCH (2002)

Review Immunology

NF-κB regulation in the immune system

QT Li et al.

NATURE REVIEWS IMMUNOLOGY (2002)

Article Geriatrics & Gerontology

Oxidative stress in brain aging - Implications for therapeutics of neurodegenerative diseases

RA Floyd et al.

NEUROBIOLOGY OF AGING (2002)

Article Chemistry, Medicinal

Elevated glutathione as a therapeutic strategy in Alzheimer's disease

DA Butterfield et al.

DRUG DEVELOPMENT RESEARCH (2002)

Article Biochemistry & Molecular Biology

Oxidative damage increases with age in a canine model of human brain aging

E Head et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Article Biochemistry & Molecular Biology

Cytokine responses in young and old rhesus monkeys: Effect of caloric restriction

P Mascarucci et al.

JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2002)

Review Cardiac & Cardiovascular Systems

Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system

AS Khan et al.

CARDIOVASCULAR RESEARCH (2002)

Article Biochemistry & Molecular Biology

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

J Lee et al.

JOURNAL OF NEUROCHEMISTRY (2002)

Review Developmental Biology

Molecular chaperones and their roles in neural cell differentiation

V Calabrese et al.

DEVELOPMENTAL NEUROSCIENCE (2002)

Article Neurosciences

NF-κB p50 is increased in neurons surviving hippocampal injury

KR Pennypacker et al.

EXPERIMENTAL NEUROLOGY (2001)

Article Cell Biology

Heat-shock protein 70 antagonizes apoptosis-inducing factor

L Ravagnan et al.

NATURE CELL BIOLOGY (2001)

Article Medicine, General & Internal

In-vivo measurement of activated microglia in dementia

A Cagnin et al.

LANCET (2001)

Article Neurosciences

Differential regulation of telomerase activity and TERT expression during brain development in mice

W Klapper et al.

JOURNAL OF NEUROSCIENCE RESEARCH (2001)

Article Multidisciplinary Sciences

Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys

T Kayo et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)

Article Multidisciplinary Sciences

Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans

HA Tissenbaum et al.

NATURE (2001)

Article Geriatrics & Gerontology

Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain

U Çakatay et al.

EXPERIMENTAL GERONTOLOGY (2001)

Article Biochemistry & Molecular Biology

Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury

WZ Duan et al.

JOURNAL OF MOLECULAR NEUROSCIENCE (2001)

Review Geriatrics & Gerontology

Prolonged longevity of hypopituitary dwarf mice

A Bartke et al.

EXPERIMENTAL GERONTOLOGY (2001)

Review Cell Biology

Apoptosis in neurodegenerative disorders

MP Mattson

NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)

Review Medicine, General & Internal

The immune system - First of two parts

PJ Delves et al.

NEW ENGLAND JOURNAL OF MEDICINE (2000)

Article Biochemistry & Molecular Biology

Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress

R Motterlini et al.

FREE RADICAL BIOLOGY AND MEDICINE (2000)

Article Biochemistry & Molecular Biology

The effect of age on cyclooxygenase-2 gene expression: NF-kappa b activation and I kappa B alpha degradation

HJ Kim et al.

FREE RADICAL BIOLOGY AND MEDICINE (2000)

Article Endocrinology & Metabolism

Alterations of haemostatic and fibrinolytic markers in adult patients with growth hormone deficiency and with acromegaly

A Sartorio et al.

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2000)