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NEUROBIOLOGY OF AGING (2006)
Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing
Anna V. Molofsky et al.
NATURE (2006)
Aging and immortality - Quasi-programmed senescence and its pharmacologic inhibition
Mikhail V. Blagosklonny
CELL CYCLE (2006)
Neuronal SIRT1 activation as a novel mechanism underlying the prevention of Alzheimer disease amyloid neuropathology by calorie restriction
Weiping Qin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Caloric restriction and intermittent fasting: Two potential diets for successful brain aging
Bronwen Martin et al.
AGEING RESEARCH REVIEWS (2006)
Mitochondria: More than just a powerhouse
Heidi M. McBride et al.
CURRENT BIOLOGY (2006)
Human progenitor cells isolated from the developing cortex undergo decreased neurogenesis and eventual senescence following expansion in vitro
Lynda S. Wright et al.
EXPERIMENTAL CELL RESEARCH (2006)
p53 regulates mitochondrial respiration
Satoaki Matoba et al.
SCIENCE (2006)
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara et al.
NATURE (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Interferon-γ is up-regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity
Jaewon Lee et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2006)
Signalling mechanisms mediated by the phosphoinositide 3-kinase/Akt cascade in synaptic plasticity and memory in the rat
Jennifer M. Horwood et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Brain reserve and dementia: a systematic review
MJ Valenzuela et al.
PSYCHOLOGICAL MEDICINE (2006)
Contribution of inflammatory processes to Alzheimer's disease: molecular mechanisms
M Sastre et al.
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE (2006)
TOR signaling in growth and metabolism
S Wullschleger et al.
CELL (2006)
TOR signaling in growth and metabolism
Stephan Wullschleger et al.
CELL (2006)
Long-lasting modulation of the induction of LTD and LTP in rat hippocampal CA1 by behavioural stress and environmental enrichment
A Artola et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2006)
Enriched environments, experience-dependent plasticity and disorders of the nervous system
Jess Nithianantharajah et al.
NATURE REVIEWS NEUROSCIENCE (2006)
SIRT1 protects against microglia-dependent amyloid-β toxicity through inhibiting NF-κB signaling
J Chen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Oxidative stress in brain aging, neurodegenerative and vascular diseases: An overview
E Mariani et al.
JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES (2005)
Exercise enhances learning and hippocampal neurogenesis in aged mice
H van Praag et al.
JOURNAL OF NEUROSCIENCE (2005)
Microglia in health and disease
SU Kim et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2005)
Adult-onset growth hormone and insulin-like growth factor I deficiency reduces neoplastic disease, modifies age-related pathology, and increases life span
WE Sonntag et al.
ENDOCRINOLOGY (2005)
Treadmill training ameliorates dopamine loss but not behavioral deficits in hemi-Parkinsonian rats
NP Poulton et al.
EXPERIMENTAL NEUROLOGY (2005)
Voluntary exercise decreases amyloid load in a transgenic model of Alzheimer's disease
PA Adlard et al.
JOURNAL OF NEUROSCIENCE (2005)
JNK extends life span and limits growth by antagonizing cellular and organism-wide responses to insulin signaling
MC Wang et al.
CELL (2005)
Resveratrol rescues mutant polyglutamine cytotoxicity in nematode and mammalian neurons
JA Parker et al.
NATURE GENETICS (2005)
The exercise-induced expression of BDNF within the hippocampus varies across life-span
PA Adlard et al.
NEUROBIOLOGY OF AGING (2005)
JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16
SW Oh et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Evidence for down-regulation of phosphoinositide 3-kinase/Akt/mammalian target of rapamycin (PI3K/Akt/mTOR)-dependent translation regulatory signaling pathways in ames dwarf mice
ZD Sharp et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2005)
The plasticity of aging: Insights from long-lived mutants
C Kenyon
CELL (2005)
Long-lived growth hormone receptor knockout mice: Interaction of reduced insulin-like growth factor I/insulin signaling and caloric restriction
KA Al-Regaiey et al.
ENDOCRINOLOGY (2005)
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
F Schwartzenberg-Bar-Yoseph et al.
CANCER RESEARCH (2004)
Circulating plasma VEGF response to exercise in sedentary and endurance-trained men
RM Kraus et al.
JOURNAL OF APPLIED PHYSIOLOGY (2004)
Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote mice
C Genoud et al.
JOURNAL OF NEUROSCIENCE (2004)
Environmental enrichment rescues protein deficits in a mouse model of Huntington's disease, indicating a possible disease mechanism
TL Spires et al.
JOURNAL OF NEUROSCIENCE (2004)
Brain region-specific, age-related, alterations in mitochondrial responses to elevated calcium
MR Brown et al.
JOURNAL OF BIOENERGETICS AND BIOMEMBRANES (2004)
Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease
N Maswood et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Insulin-like growth factor I is required for vessel remodeling in the adult brain
C Lopez-Lopez et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Sir2 mediates longevity in the fly through a pathway related to calorie restriction
B Rogina et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
F Yeung et al.
EMBO JOURNAL (2004)
AKT1 drives endothelial cell membrane asymmetry and microglial activation through Bcl-xL and caspase 1, 3, and 9
ZZ Chonga et al.
EXPERIMENTAL CELL RESEARCH (2004)
Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition
S Vaynman et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2004)
Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo
J Farmer et al.
NEUROSCIENCE (2004)
Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin
Y Ding et al.
NEUROSCIENCE (2004)
The role of oxidative damage and stress in aging
A Bokov et al.
MECHANISMS OF AGEING AND DEVELOPMENT (2004)
Additive regulation of hepatic gene expression by dwarfism and caloric restriction
T Tsuchiya et al.
PHYSIOLOGICAL GENOMICS (2004)
Protective role of Bcl-2 on β-amyloid-induced cell death of differentiated PC 12 cells:: reduction of NF-kB and p38 MAP kinase activation
YS Song et al.
NEUROSCIENCE RESEARCH (2004)
Elevation of mitochondrial glutathione by γ-glutamylcysteine ethyl ester protects mitochondria against peroxynitrite-induced oxidative stress
J Drake et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Redox regulation of heat shock protein expression in aging and neurodegenerative disorders associated with oxidative stress: A nutritional approach
V Calabrese et al.
AMINO ACIDS (2003)
Forkhead transcription factor FOX01 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscle during energy deprivation
T Furuyama et al.
BIOCHEMICAL JOURNAL (2003)
AKT1 protects against inflammatory microglial activation through maintenance of membrane asymmetry and modulation of cysteine protease activity
JQ Kang et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2003)
Gene-diet interactions in brain aging and neurodegenerative disorders
MP Mattson
ANNALS OF INTERNAL MEDICINE (2003)
Critical role for Akt1 in the modulation of apoptotic phosphatidylserine exposure and microglial activation
JQ Kang et al.
MOLECULAR PHARMACOLOGY (2003)
Disruption of thiol homeostasis and nitrosative stress in the cerebrospinal fluid of patients with active multiple sclerosis: Evidence for a protective role of acetylcarnitine
V Calabrese et al.
NEUROCHEMICAL RESEARCH (2003)
Brain-derived neurotrophic factor val66met polymorphism affects human memory-related hippocampal activity and predicts memory performance
AR Hariri et al.
JOURNAL OF NEUROSCIENCE (2003)
Inflammatory markers and cognition in well-functioning African-American and white elders
K Yaffe et al.
NEUROLOGY (2003)
Control of synaptic strength, a novel function of Akt
QH Wang et al.
NEURON (2003)
Nutritional and hormonal factors control the gene expression of FoxOs, the mammalian homologues of DAF-16
M Imae et al.
JOURNAL OF MOLECULAR ENDOCRINOLOGY (2003)
Glutathione pathways in the brain
R Dringen et al.
BIOLOGICAL CHEMISTRY (2003)
Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice
WZ Duan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
From neurodegeneration to neurohomeostasis: The roles of ubliquitin
RJ Mayer
DRUG NEWS & PERSPECTIVES (2003)
Possible beneficial role of exercise in modulating low-grade inflammation in the elderly
BK Pedersen et al.
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS (2003)
Ectopic expression of catalase in Drosophila mitochondria increases stress resistance but not longevity
RJ Mockett et al.
FREE RADICAL BIOLOGY AND MEDICINE (2003)
Age-associated changes in central nervous system glycerolipid composition and metabolism
NM Giusto et al.
NEUROCHEMICAL RESEARCH (2002)
NF-κB regulation in the immune system
QT Li et al.
NATURE REVIEWS IMMUNOLOGY (2002)
Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice
J Lee et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Oxidative stress in brain aging - Implications for therapeutics of neurodegenerative diseases
RA Floyd et al.
NEUROBIOLOGY OF AGING (2002)
Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer's disease
R Dei et al.
ACTA NEUROPATHOLOGICA (2002)
Elevated glutathione as a therapeutic strategy in Alzheimer's disease
DA Butterfield et al.
DRUG DEVELOPMENT RESEARCH (2002)
Oxidative damage increases with age in a canine model of human brain aging
E Head et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Cytokine responses in young and old rhesus monkeys: Effect of caloric restriction
P Mascarucci et al.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH (2002)
Regional distribution of heme oxygenase, HSP70, and glutathione in brain: Relevance for endogenous oxidant/antioxidant balance and stress tolerance
V Calabrese et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2002)
Growth hormone, insulin-like growth factor-1 and the aging cardiovascular system
AS Khan et al.
CARDIOVASCULAR RESEARCH (2002)
Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice
J Lee et al.
JOURNAL OF NEUROCHEMISTRY (2002)
Molecular chaperones and their roles in neural cell differentiation
V Calabrese et al.
DEVELOPMENTAL NEUROSCIENCE (2002)
The aging brain. Changes in the neuronal insulin/insulin receptor signal transduction cascade trigger late-onset sporadic Alzheimer disease (SAD). A mini-review
S Hoyer
JOURNAL OF NEURAL TRANSMISSION (2002)
Estrogen and exercise interact to regulate brain-derived neurotrophic factor mRNA and protein expression in the hippocampus
NC Berchtold et al.
EUROPEAN JOURNAL OF NEUROSCIENCE (2001)
NF-κB p50 is increased in neurons surviving hippocampal injury
KR Pennypacker et al.
EXPERIMENTAL NEUROLOGY (2001)
Heat-shock protein 70 antagonizes apoptosis-inducing factor
L Ravagnan et al.
NATURE CELL BIOLOGY (2001)
In-vivo measurement of activated microglia in dementia
A Cagnin et al.
LANCET (2001)
Circulating insulin-like growth factor I mediates the protective effects of physical exercise against brain insults of different etiology and anatomy
E Carro et al.
JOURNAL OF NEUROSCIENCE (2001)
Differential regulation of telomerase activity and TERT expression during brain development in mice
W Klapper et al.
JOURNAL OF NEUROSCIENCE RESEARCH (2001)
Influences of aging and caloric restriction on the transcriptional profile of skeletal muscle from rhesus monkeys
T Kayo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein
DJ Clancy et al.
SCIENCE (2001)
Increased dosage of a sir-2 gene extends lifespan in Caenorhabditis elegans
HA Tissenbaum et al.
NATURE (2001)
Circulating insulin-like growth factor I mediates exercise-induced increases in the number of new neurons in the adult hippocampus
JL Trejo et al.
JOURNAL OF NEUROSCIENCE (2001)
Immunohistochemical investigation of the brain of aged dogs. I. Detection of neurofibrillary tangles and of 4-hydroxynonenal protein, an oxidative damage product, in senile plaques
N Papaioannou et al.
AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS (2001)
Relation of oxidative protein damage and nitrotyrosine levels in the aging rat brain
U Çakatay et al.
EXPERIMENTAL GERONTOLOGY (2001)
Oxidative stress and neuronal DNA fragmentation mediate age-dependent vulnerability to the mitochondrial toxin, 3-nitropropionic acid, in the mouse striatum
GW Kim et al.
NEUROBIOLOGY OF DISEASE (2001)
Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury
WZ Duan et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2001)
Prolonged longevity of hypopituitary dwarf mice
A Bartke et al.
EXPERIMENTAL GERONTOLOGY (2001)
Signatures of hippocampal oxidative stress in aged spatial learning-impaired rodents
MM Nicolle et al.
NEUROSCIENCE (2001)
Role of free radicals in the neurodegenerative diseases - Therapeutic implications for antioxidant treatment
B Halliwell
DRUGS & AGING (2001)
Apoptosis in neurodegenerative disorders
MP Mattson
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2000)
NO synthase and NO-dependent signal pathways in brain aging and neurodegenerative disorders: The role of oxidant/antioxidant balance
V Calabrese et al.
NEUROCHEMICAL RESEARCH (2000)
Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome
HM Beere et al.
NATURE CELL BIOLOGY (2000)
The immune system - First of two parts
PJ Delves et al.
NEW ENGLAND JOURNAL OF MEDICINE (2000)
Long-term environmental enrichment leads to regional increases in neurotrophin levels in rat brain
BR Ickes et al.
EXPERIMENTAL NEUROLOGY (2000)
Curcumin, an antioxidant and anti-inflammatory agent, induces heme oxygenase-1 and protects endothelial cells against oxidative stress
R Motterlini et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Brain-derived neurotrophic factor differentially regulates excitatory and inhibitory synaptic transmission in hippocampal cultures
MM Bolton et al.
JOURNAL OF NEUROSCIENCE (2000)
The effect of age on cyclooxygenase-2 gene expression: NF-kappa b activation and I kappa B alpha degradation
HJ Kim et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Enrichment induces structural changes and recovery from nonspatial memory deficits in CA1 NMDAR1-knockout mice
C Rampon et al.
NATURE NEUROSCIENCE (2000)
Alterations of haemostatic and fibrinolytic markers in adult patients with growth hormone deficiency and with acromegaly
A Sartorio et al.
EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES (2000)