Journal
BEHAVIOR GENETICS
Volume 51, Issue 5, Pages 592-606Publisher
SPRINGER
DOI: 10.1007/s10519-021-10076-6
Keywords
Aggressive behavior; Aggression; Life-course; Development; Polygenic score; Rolling weights
Funding
- Amsterdam Law and Behavior Institute (A-LAB
- Vrije Universtiteit, Amsterdam)
- NWO [451-16-014, 480-15001/674]
- Netherlands Organization for Scientific Research (NWO) [575-25-006, 480-04-004, 904-61-090, 904-61-193, 400-05-717, 311-60008, SPI 56-464-14192]
- Avera Institute for Human Genetics
- ZonMw [849200011, 531003014]
- NHMRC [APP1069141, APP1172917, APP1172990]
- John Templeton Foundation (Genetics and Human Agency Project)
- Young and Well Cooperative Research Centre under the Australian Government's Cooperative Research Centres Program
- National Health and Medical Research Council (NHMRC) Boosting Dementia Research Initiative-Team Grant [APP1095227]
- Australian NHMRC
- NIH (NIAAA)
- NIH (NIDA)
- QIMR Berghofer International PhD Scholarship
- QIMR Berghofer Research Fellowship
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By analyzing genetic influences on aggressive behavior, it was found that genetic influences expressed in childhood may continue to play a role into later adulthood, according to results from a molecular genetics perspective.
We test whether genetic influences that explain individual differences in aggression in early life also explain individual differences across the life-course. In two cohorts from The Netherlands (N = 13,471) and Australia (N = 5628), polygenic scores (PGSs) were computed based on a genome-wide meta-analysis of childhood/adolescence aggression. In a novel analytic approach, we ran a mixed effects model for each age (Netherlands: 12-70 years, Australia: 16-73 years), with observations at the focus age weighted as 1, and decaying weights for ages further away. We call this approach a 'rolling weights' model. In The Netherlands, the estimated effect of the PGS was relatively similar from age 12 to age 41, and decreased from age 41-70. In Australia, there was a peak in the effect of the PGS around age 40 years. These results are a first indication from a molecular genetics perspective that genetic influences on aggressive behavior that are expressed in childhood continue to play a role later in life.
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