Related references
Note: Only part of the references are listed.Four novel optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in Mainland China
Lu Yang et al.
NEUROBIOLOGY OF AGING (2021)
The Autophagy Lysosomal Pathway and Neurodegeneration
Steven Finkbeiner
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2020)
NT-3 Promotes Oligodendrocyte Proliferation and Nerve Function Recovery After Spinal Cord Injury by Inhibiting Autophagy Pathway
Yan Cong et al.
JOURNAL OF SURGICAL RESEARCH (2020)
Reduced autophagy upon C9ORF72 loss synergizes with dipeptide repeat protein toxicity in G4C2 repeat expansion disorders
Manon Boivin et al.
EMBO JOURNAL (2020)
β2-adrenoceptor activation improves skeletal muscle autophagy in neurogenic myopathy
Juliane C. Campos et al.
FASEB JOURNAL (2020)
A robust TDP-43 knock-in mouse model of ALS
Shih-Ling Huang et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2020)
Ibudilast enhances the clearance of SOD1 and TDP-43 aggregates through TFEB-mediated autophagy and lysosomal biogenesis: The new molecular mechanism of ibudilast and its implication for neuroprotective therapy
Yanming Chen et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2020)
A proposal for new diagnostic criteria for ALSY
Jeremy M. Shefner et al.
CLINICAL NEUROPHYSIOLOGY (2020)
Degradation of engulfed mitochondria is rate-limiting in Optineurin-mediated mitophagy in neurons
Chantell S. Evans et al.
ELIFE (2020)
Autophagy in neurodegeneration: New insights underpinning therapy for neurological diseases
Olga Corti et al.
JOURNAL OF NEUROCHEMISTRY (2020)
Oligodendrocyte pathology exceeds axonal pathology in white matter in human amyotrophic lateral sclerosis
Alejandro Lorente Pons et al.
JOURNAL OF PATHOLOGY (2020)
Reduced C9ORF72 function exacerbates gain of toxicity from ALS/FTD-causing repeat expansion in C9orf72
Qiang Zhu et al.
NATURE NEUROSCIENCE (2020)
The Loss of TBK1 Kinase Activity in Motor Neurons or in All Cell Types Differentially Impacts ALS Disease Progression in SOD1 Mice
Valeria Gerbino et al.
NEURON (2020)
Current and projected future economic burden of Parkinson's disease in the U.S.
Wenya Yang et al.
NPJ PARKINSONS DISEASE (2020)
Glia in neurodegeneration: Drivers of disease or along for the ride?
Amy J. Gleichman et al.
NEUROBIOLOGY OF DISEASE (2020)
ALS/FTD mutations in UBQLN2 impede autophagy by reducing autophagosome acidification through loss of function
Josephine J. Wu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2020)
C9orf72 in myeloid cells suppresses STING-induced inflammation
Madelyn E. McCauley et al.
NATURE (2020)
PGC-1α overexpression increases transcription factor EB nuclear localization and lysosome abundance in dystrophin-deficient skeletal muscle
Hannah R. Spaulding et al.
PHYSIOLOGICAL REPORTS (2020)
Implications of Microglia in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia
Henriette Haukedal et al.
JOURNAL OF MOLECULAR BIOLOGY (2019)
Ubiquilins regulate autophagic flux through mTOR signalling and lysosomal acidification
Mumine Senturk et al.
NATURE CELL BIOLOGY (2019)
Efficacy and safety of mTOR inhibitors (rapamycin and its analogues) for tuberous sclerosis complex: a meta-analysis
Min Li et al.
ORPHANET JOURNAL OF RARE DISEASES (2019)
Schwann cell-specific PTEN and EGFR dysfunctions affect neuromuscular junction development by impairing Agrin signaling and autophagy
Shi-Jie Zhang et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2019)
Expression of WIPI2B counteracts age-related decline in autophagosome biogenesis in neurons
Andrea K. H. Stavoe et al.
ELIFE (2019)
p62/SQSTM1: 'Jack of all trades' in health and cancer
Pablo Sanchez-Martin et al.
FEBS JOURNAL (2019)
Heterozygous Tbk1 loss has opposing effects in early and late stages of ALS in mice
David Brenner et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2019)
Elevated Peripheral Myelin Protein 22, Reduced Mitotic Potential, and Proteasome Impairment in Dermal Fibroblasts from Charcot-Marie-Tooth Disease Type 1A Patients
Sooyeon Lee et al.
AMERICAN JOURNAL OF PATHOLOGY (2018)
Cerebrospinal fluid macrophage biomarkers in amyotrophic lateral sclerosis
Alexander G. Thompson et al.
ANNALS OF NEUROLOGY (2018)
Nrf2-Keap1 signaling in oxidative and reductive stress
Ilaria Bellezza et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2018)
Exploring the genetics and non-cell autonomous mechanisms underlying ALS/FTLD
Hongbo Chen et al.
CELL DEATH AND DIFFERENTIATION (2018)
Polyubiquitin chain-induced p62 phase separation drives autophagic cargo segregation
Daxiao Sun et al.
CELL RESEARCH (2018)
p62 filaments capture and present ubiquitinated cargos for autophagy
Gabriele Zaffagnini et al.
EMBO JOURNAL (2018)
The complex relationship between TFEB transcription factor phosphorylation and subcellular localization
Rosa Puertollano et al.
EMBO JOURNAL (2018)
Blocking Autophagy in Oligodendrocytes Limits Functional Recovery after Spinal Cord Injury
Sujata Saraswat Ohri et al.
JOURNAL OF NEUROSCIENCE (2018)
Autophagy and mitophagy flux in young and aged skeletal muscle following chronic contractile activity
Heather N. Carter et al.
JOURNAL OF PHYSIOLOGY-LONDON (2018)
Rapamycin treatment for amyotrophic lateral sclerosis Protocol for a phase II randomized, double-blind, placebo-controlled, multicenter, clinical trial (RAP-ALS trial)
Jessica Mandrioli et al.
MEDICINE (2018)
WDR41 supports lysosomal response to changes in amino acid availability
Joseph Amick et al.
MOLECULAR BIOLOGY OF THE CELL (2018)
Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons
Yingxiao Shi et al.
NATURE MEDICINE (2018)
Sphingosine kinase 1-associated autophagy differs between neurons and astrocytes
Jose F. Moruno-Manchon et al.
CELL DEATH & DISEASE (2018)
C9ORF72 repeat expansion causes vulnerability of motor neurons to Ca2+-permeable AMPA receptor-mediated excitotoxicity
Bhuvaneish T. Selvaraj et al.
NATURE COMMUNICATIONS (2018)
Isogenic FUS-eGFP iPSC Reporter Lines Enable Quantification of FUS Stress Granule Pathology that Is Rescued by Drugs Inducing Autophagy
Lara Marrone et al.
STEM CELL REPORTS (2018)
Pathological Endogenous α-Synuclein Accumulation in Oligodendrocyte Precursor Cells Potentially Induces Inclusions in Multiple System Atrophy
Seiji Kaji et al.
STEM CELL REPORTS (2018)
Dysfunction of Optineurin in Amyotrophic Lateral Sclerosis and Glaucoma
Reka P. Toth et al.
FRONTIERS IN IMMUNOLOGY (2018)
p62/SQSTM1-steering the cell through health and disease
Pablo Sanchez-Martin et al.
JOURNAL OF CELL SCIENCE (2018)
Animal models of amyotrophic lateral sclerosis: a comparison of model validity
Jessica R. Morrice et al.
NEURAL REGENERATION RESEARCH (2018)
Adult neurogenesis and neurodegenerative diseases: A systems biology perspective
Emrin Horgusluoglu et al.
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS (2017)
Roles of mitophagy in cellular physiology and development
Joern Dengjel et al.
CELL AND TISSUE RESEARCH (2017)
Mitochondrial quality control by the Pink1/Parkin system
Cornelia Rueb et al.
CELL AND TISSUE RESEARCH (2017)
Regulation of selective autophagy: the p62/SQSTM1 paradigm
Trond Lamark et al.
SIGNALLING MECHANISMS IN AUTOPHAGY (2017)
Exercise training protects against aging-induced mitochondrial fragmentation in mouse skeletal muscle in a PGC-1αa dependent manner
Jens Frey Halling et al.
EXPERIMENTAL GERONTOLOGY (2017)
Schwann cell dedifferentiation-associated demyelination leads to exocytotic myelin clearance in inflammatory segmental demyelination
So Young Jang et al.
GLIA (2017)
Schwann cell-specific deletion of the endosomal PI 3-kinase Vps34 leads to delayed radial sorting of axons, arrested myelination, and abnormal ErbB2-ErbB3 tyrosine kinase signaling
Anne M. Logan et al.
GLIA (2017)
Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
Ainhoa Plaza-Zabala et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2017)
Sphingosine and Sphingosine Kinase 1 Involvement in Endocytic Membrane Trafficking
Santiago Lima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
Genetic epidemiology of amyotrophic lateral sclerosis: a systematic review and meta-analysis
Zhang-Yu Zou et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2017)
Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage
Veronica Lindstrom et al.
MOLECULAR AND CELLULAR NEUROSCIENCE (2017)
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities
Fiona M. Menzies et al.
NEURON (2017)
Distinct roles for motor neuron autophagy early and late in the SOD1G93A mouse model of ALS
Noam D. Rudnick et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Schwann cells use TAM receptor-mediated phagocytosis in addition to autophagy to clear myelin in a mouse model of nerve injury
Amanda Brosius Lutz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2017)
Genetics of amyotrophic lateral sclerosis
P. Corcia et al.
REVUE NEUROLOGIQUE (2017)
Progressive Motor Neuron Pathology and the Role of Astrocytes in a Human Stem Cell Model of VCP-Related ALS
Claire E. Hall et al.
CELL REPORTS (2017)
Amyotrophic lateral sclerosis patient iPSC-derived astrocytes impair autophagy via non-cell autonomous mechanisms
Martin Madill et al.
MOLECULAR BRAIN (2017)
TBK1: a new player in ALS linking autophagy and neuroinflammation
James A. Oakes et al.
MOLECULAR BRAIN (2017)
Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator
Jennifer Jung et al.
eLife (2017)
MicroRNA-101 Modulates Autophagy and Oligodendroglial Alpha-Synuclein Accumulation in Multiple System Atrophy
Elvira Valera et al.
FRONTIERS IN MOLECULAR NEUROSCIENCE (2017)
Reactive Astrocytes Promote ALS-like Degeneration and Intracellular Protein Aggregation in Human Motor Neurons by Disrupting Autophagy through TGF-β1
Pratibha Tripathi et al.
STEM CELL REPORTS (2017)
Environment matters: microglia function and dysfunction in a changing world
Richa Hanamsagar et al.
CURRENT OPINION IN NEUROBIOLOGY (2017)
A Unique Microglia Type Associated with Restricting Development of Alzheimer's Disease
Hadas Keren-Shaul et al.
CELL (2017)
Modelling amyotrophic lateral sclerosis: progress and possibilities
Philip Van Damme et al.
DISEASE MODELS & MECHANISMS (2017)
ALS/FTLD: experimental models and reality
Rachel H. Tan et al.
ACTA NEUROPATHOLOGICA (2017)
Alternative rapamycin treatment regimens mitigate the impact of rapamycin on glucose homeostasis and the immune system
Sebastian I. Arriola Apelo et al.
AGING CELL (2016)
Clinical features of TBK1 carriers compared with C9orf72, GRN and non-mutation carriers in a Belgian cohort
Sara Van Mossevelde et al.
BRAIN (2016)
TDP-43 loss of function increases TFEB activity and blocks autophagosome-lysosome fusion
Qin Xia et al.
EMBO JOURNAL (2016)
Autophagy as a Potential Target for Sarcopenia
Jingjing Fan et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2016)
The C9orf72 repeat size correlates with onset age of disease, DNA methylation and transcriptional downregulation of the promoter
I. Gijselinck et al.
MOLECULAR PSYCHIATRY (2016)
Neurodegeneration in frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9orf72 is linked to TDP-43 pathology and not associated with aggregated forms of dipeptide repeat proteins
Y. Davidson et al.
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY (2016)
Full ablation of C9orf72 in mice causes immune system-related pathology and neoplastic events but no motor neuron defects
Emma Sudria-Lopez et al.
ACTA NEUROPATHOLOGICA (2016)
The endocytic pathway in microglia during health, aging and Alzheimer's disease
Santiago Sole-Domenech et al.
AGEING RESEARCH REVIEWS (2016)
Mitochondrial maintenance via autophagy contributes to functional skeletal muscle regeneration and remodeling
Anna S. Nichenko et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)
Autophagy regulates cytoplasmic remodeling during cell reprogramming in a zebrafish model of muscle regeneration
Alfonso Saera-Vila et al.
AUTOPHAGY (2016)
SPHK1/sphingosine kinase 1-mediated autophagy differs between neurons and SH-SY5Y neuroblastoma cells
Jose Felix Moruno Manchon et al.
AUTOPHAGY (2016)
TARDBP/TDP-43 regulates autophagy in both MTORC1-dependent and MTORC1-independent manners
Zheng Ying et al.
AUTOPHAGY (2016)
Spatiotemporal dynamics of autophagy receptors in selective mitophagy
Andrew S. Moore et al.
AUTOPHAGY (2016)
Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
Daniel J. Klionsky et al.
AUTOPHAGY (2016)
Disturbance of proteasomal and autophagic protein degradation pathways by amyotrophic lateral sclerosis-linked mutations in ubiquilin 2
Mayuko Osaka et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2016)
New perspectives on the use of mTOR inhibitors in allogeneic haematopoietic stem cell transplantation and graft-versus-host disease
Mathias Lutz et al.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY (2016)
KIF1A/UNC-104 Transports ATG-9 to Regulate Neurodevelopment and Autophagy at Synapses
Andrea K. H. Stavoe et al.
DEVELOPMENTAL CELL (2016)
Mfn2 deficiency links age-related sarcopenia and impaired autophagy to activation of an adaptive mitophagy pathway
David Sebastian et al.
EMBO JOURNAL (2016)
Lost & found: C9ORF72 and the autophagy pathway in ALS/FTD
Sandra Almeida et al.
EMBO JOURNAL (2016)
Loss of C9ORF72 impairs autophagy and synergizes with polyQ Ataxin-2 to induce motor neuron dysfunction and cell death
Chantal Sellier et al.
EMBO JOURNAL (2016)
The C9orf72 protein interacts with Rab1a and the ULK1 complex to regulate initiation of autophagy
Christopher P. Webster et al.
EMBO JOURNAL (2016)
Role of chaperone-mediated autophagy in metabolism
Inmaculada Tasset et al.
FEBS JOURNAL (2016)
The search for true numbers of neurons and glial cells in the human brain: A review of 150 years of cell counting
Christopher S. von Bartheld et al.
JOURNAL OF COMPARATIVE NEUROLOGY (2016)
Autophagy Promotes Peripheral Nerve Regeneration and Motor Recovery Following Sciatic Nerve Crush Injury in Rats
Hai-cheng Huang et al.
JOURNAL OF MOLECULAR NEUROSCIENCE (2016)
Walking the tightrope: proteostasis and neurodegenerative disease
Justin J. Yerbury et al.
JOURNAL OF NEUROCHEMISTRY (2016)
Defective Phagocytic Corpse Processing Results in Neurodegeneration and Can Be Rescued by TORC1 Activation
Jon Iker Etchegaray et al.
JOURNAL OF NEUROSCIENCE (2016)
Compartment-Specific Regulation of Autophagy in Primary Neurons
Sandra Maday et al.
JOURNAL OF NEUROSCIENCE (2016)
Oligomeropathies and Pathogenesis of Alzheimer and Parkinson's Diseases
Gianluigi Forloni et al.
MOVEMENT DISORDERS (2016)
Rare variants in SQSTM1 and VCP genes and risk of sporadic inclusion body myositis
Qiang Gang et al.
NEUROBIOLOGY OF AGING (2016)
Phosphorylation of OPTN by TBK1 enhances its binding to Ub chains and promotes selective autophagy of damaged mitochondria
Benjamin Richter et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2016)
C9orf72 is required for proper macrophage and microglial function in mice
J. G. O'Rourke et al.
SCIENCE (2016)
Loss-of-function mutations in the C9ORF72 mouse ortholog cause fatal autoimmune disease
Aaron Burberry et al.
SCIENCE TRANSLATIONAL MEDICINE (2016)
The Autophagy-Lysosomal Pathway in Neurodegeneration: A TFEB Perspective
Heidi Martini-Stoica et al.
TRENDS IN NEUROSCIENCES (2016)
VCP recruitment to mitochondria causes mitophagy impairment and neurodegeneration in models of Huntington's disease
Xing Guo et al.
NATURE COMMUNICATIONS (2016)
Sphingosine Kinase 1 Cooperates with Autophagy to Maintain Endocytic Membrane Trafficking
Megan M. Young et al.
CELL REPORTS (2016)
Loss of C9orf72 Enhances Autophagic Activity via Deregulated mTOR and TFEB Signaling
Janet Ugolino et al.
PLOS GENETICS (2016)
A C9ORF72/SMCR8-containing complex regulates ULK1 and plays a dual role in autophagy
Mei Yang et al.
SCIENCE ADVANCES (2016)
The ALS/FTLD associated protein C9orf72 associates with SMCR8 and WDR41 to regulate the autophagy-lysosome pathway
Peter M. Sullivan et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2016)
C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice
Amanda Atanasio et al.
SCIENTIFIC REPORTS (2016)
Transcriptional induction of the heat shock protein B8 mediates the clearance of misfolded proteins responsible for motor neuron diseases
Valeria Crippa et al.
SCIENTIFIC REPORTS (2016)
Cerebellar c9RAN proteins associate with clinical and neuropathological characteristics of C9ORF72 repeat expansion carriers
Tania F. Gendron et al.
ACTA NEUROPATHOLOGICA (2015)
Quantitative analysis and clinico-pathological correlations of different dipeptide repeat protein pathologies in C9ORF72 mutation carriers
Ian R. A. Mackenzie et al.
ACTA NEUROPATHOLOGICA (2015)
Frontotemporal dementia caused by CHMP2B mutation is characterised by neuronal lysosomal storage pathology
Emma L. Clayton et al.
ACTA NEUROPATHOLOGICA (2015)
Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease
Cyril Pottier et al.
ACTA NEUROPATHOLOGICA (2015)
Copy Number Variations of TBK1 in Australian Patients With Primary Open-Angle Glaucoma
Mona S. Awadalla et al.
AMERICAN JOURNAL OF OPHTHALMOLOGY (2015)
Role of PGC-1α during acute exercise-induced autophagy and mitophagy in skeletal muscle
Anna Vainshtein et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2015)
Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon
Daichao Xu et al.
AUTOPHAGY (2015)
Lysosomal calcium regulates autophagy
Diego L. Medina et al.
AUTOPHAGY (2015)
Transcriptional and epigenetic regulation of autophagy in aging
Louis R. Lapierre et al.
AUTOPHAGY (2015)
Muscle-specificity of age-related changes in markers of autophagy and sphingolipid metabolism
David W. Russ et al.
BIOGERONTOLOGY (2015)
A fruitful endeavor: Modeling ALS in the fruit fly
Ian Casci et al.
BRAIN RESEARCH (2015)
TBK1 controls autophagosomal engulfment of polyubiquitinated mitochondria through p62/SQSTM1 phosphorylation
Gen Matsumoto et al.
HUMAN MOLECULAR GENETICS (2015)
Reduced protein turnover mediates functional deficits in transgenic mice expressing the 25 kDa C-terminal fragment of TDP-43
Antonella Caccamo et al.
HUMAN MOLECULAR GENETICS (2015)
Physical exercise increases autophagic signaling through ULK1 in human skeletal muscle
Andreas Buch Moller et al.
JOURNAL OF APPLIED PHYSIOLOGY (2015)
Schwann cell autophagy, myelinophagy, initiates myelin clearance from injured nerves
Jose A. Gomez-Sanchez et al.
JOURNAL OF CELL BIOLOGY (2015)
Autophagy and neurodegeneration
Rebecca A. Frake et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Emerging mechanisms of molecular pathology in ALS
Owen M. Peters et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Mitochondrial impairment and oxidative stress compromise autophagosomal degradation of α-synuclein in oligodendroglial cells
Katharina Pukass et al.
JOURNAL OF NEUROCHEMISTRY (2015)
The PINK1-PARKIN Mitochondrial Ubiquitylation Pathway Drives a Program of OPTN/NDP52 Recruitment and TBK1 Activation to Promote Mitophagy
Jin-Mi Heo et al.
MOLECULAR CELL (2015)
Viral expression of ALS-linked ubiquilin-2 mutants causes inclusion pathology and behavioral deficits in mice
Carolina Ceballos-Diaz et al.
MOLECULAR NEURODEGENERATION (2015)
The ubiquitin kinase PINK1 recruits autophagy receptors to induce mitophagy
Michael Lazarou et al.
NATURE (2015)
Haploinsufficiency of TBK1 causes familial ALS and fronto-temporal dementia
Axel Freischmidt et al.
NATURE NEUROSCIENCE (2015)
Compromised autophagy and neurodegenerative diseases
Fiona M. Menzies et al.
NATURE REVIEWS NEUROSCIENCE (2015)
TBK1 mutation frequencies in French frontotemporal dementia and amyotrophic lateral sclerosis cohorts
Isabelle Le Ber et al.
NEUROBIOLOGY OF AGING (2015)
SQSTM1 splice site mutation in distal myopathy with rimmed vacuoles
Robert C. Bucelli et al.
NEUROLOGY (2015)
Loss of TBK1 is a frequent cause of frontotemporal dementia in a Belgian cohort
Ilse Gijselinck et al.
NEUROLOGY (2015)
C9orf72 BAC Transgenic Mice Display Typical Pathologic Features of ALS/FTD
Jacqueline G. O'Rourke et al.
NEURON (2015)
Exome sequencing in amyotrophic lateral sclerosis identifies risk genes and pathways
Elizabeth T. Cirulli et al.
SCIENCE (2015)
Tissue-based map of the human proteome
Mathias Uhlen et al.
SCIENCE (2015)
Compartment-dependent mitochondrial alterations in experimental ALS, the effects of mitophagy and mitochondriogenesis
Gianfranco Natale et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2015)
Microglia Function in Central Nervous System Development and Plasticity
Dorothy P. Schafer et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2015)
Disrupted autophagy after spinal cord injury is associated with ER stress and neuronal cell death
S. Liu et al.
CELL DEATH & DISEASE (2015)
Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation
Jiayi Yu et al.
NATURE COMMUNICATIONS (2015)
Human iPSC-derived motoneurons harbouring TARDBP or C9ORF72 ALS mutations are dysfunctional despite maintaining viability
Anna-Claire Devlin et al.
NATURE COMMUNICATIONS (2015)
Amino Acid Activation of mTORC1 by a PB1-Domain-Driven Kinase Complex Cascade
Juan F. Linares et al.
CELL REPORTS (2015)
Ubiquilin-2 drives NF-κB activity and cytosolic TDP-43 aggregation in neuronal cells
Vincent Picher-Martel et al.
MOLECULAR BRAIN (2015)
Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates
Junghyun Lim et al.
PLOS GENETICS (2015)
Optineurin mutations in patients with sporadic amyotrophic lateral sclerosis in China
Chengyu Li et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2015)
Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy
Bettina Wurzer et al.
ELIFE (2015)
Dipeptide repeat protein inclusions are rare in the spinal cord and almost absent from motor neurons in C9ORF72 mutant amyotrophic lateral sclerosis and are unlikely to cause their degeneration
Jorge Gomez-Deza et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2015)
Pathogenic Ubqln2 gains toxic properties to induce neuron death
Qinxue Wu et al.
ACTA NEUROPATHOLOGICA (2015)
Sqstm1 knock-down causes a locomotor phenotype ameliorated by rapamycin in a zebrafish model of ALS/FTLD
Serena Lattante et al.
HUMAN MOLECULAR GENETICS (2015)
Loss of Fig4 in both Schwann cells and motor neurons contributes to CMT4J neuropathy
Ilaria Vaccari et al.
HUMAN MOLECULAR GENETICS (2015)
Insights into the Role of the Unusual Disulfide Bond in Copper-Zinc Superoxide Dismutase
Kevin Sea et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Interferon-stimulated Gene 15 (ISG15) and ISG15-linked Proteins Can Associate with Members of the Selective Autophagic Process, Histone Deacetylase 6 (HDAC6) and SQSTM1/p62
Hiroshi Nakashima et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2015)
Autophagy Is Involved in the Reduction of Myelinating Schwann Cell Cytoplasm during Myelin Maturation of the Peripheral Nerve
So Young Jang et al.
PLOS ONE (2015)
Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies
Aaron Ciechanover et al.
EXPERIMENTAL AND MOLECULAR MEDICINE (2015)
The neuropathology associated with repeat expansions in the C9ORF72 gene
Ian R. A. Mackenzie et al.
ACTA NEUROPATHOLOGICA (2014)
An Overview of Autophagy: Morphology, Mechanism, and Regulation
Katherine R. Parzych et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
Expression of the autophagy substrate SQSTM1/p62 is restored during prolonged starvation depending on transcriptional upregulation and autophagy- derived amino acids
Mayurbhai Himatbhai Sahani et al.
AUTOPHAGY (2014)
MAPK8IP1/JIP1 regulates the trafficking of autophagosomes in neurons
Meng-meng Fu et al.
AUTOPHAGY (2014)
Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome
Mi-Hyang Cho et al.
AUTOPHAGY (2014)
c-Jun activation in Schwann cells protects against loss of sensory axons in inherited neuropathy
Janina Hantke et al.
BRAIN (2014)
Rab1A Is an mTORC1 Activator and a Colorectal Oncogene
Janice D. Thomas et al.
CANCER CELL (2014)
Ubiquitylation of Autophagy Receptor Optineurin by HACE1 Activates Selective Autophagy for Tumor Suppression
Zhengzhao Liu et al.
CANCER CELL (2014)
Chaperone-mediated autophagy: roles in disease and aging
Ana Maria Cuervo et al.
CELL RESEARCH (2014)
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
David Heras-Sandoval et al.
CELLULAR SIGNALLING (2014)
Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway
Sandra Maday et al.
DEVELOPMENTAL CELL (2014)
SQSTM1 mutations - Bridging Paget disease of bone and ALS/FTLD
Sarah L. Rea et al.
EXPERIMENTAL CELL RESEARCH (2014)
Rapamycin nanoparticles target defective autophagy in muscular dystrophy to enhance both strength and cardiac function
Kristin P. Bibee et al.
FASEB JOURNAL (2014)
Sulforaphane induces autophagy through ERK activation in neuronal cells
Chulman Jo et al.
FEBS LETTERS (2014)
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking
Manal A. Farg et al.
HUMAN MOLECULAR GENETICS (2014)
Small Molecule Screening in Human Induced Pluripotent Stem Cell-derived Terminal Cell Types
Sandra J. Engle et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Mitophagy of damaged mitochondria occurs locally in distal neuronal axons and requires PINK1 and Parkin
Ghazaleh Ashrafi et al.
JOURNAL OF CELL BIOLOGY (2014)
C9orf72 expansion as a possible genetic cause of Huntington disease phenocopy syndrome
Vladimir S. Kostic et al.
JOURNAL OF NEUROLOGY (2014)
The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation
Yvette C. Wong et al.
JOURNAL OF NEUROSCIENCE (2014)
Chitosan Coated Polylactic Acid Nanoparticle-Mediated Combinatorial Delivery of Cisplatin and siRNA/Plasmid DNA Chemosensitizes Cisplatin-Resistant Human Ovarian Cancer Cells
Anish Babu et al.
MOLECULAR PHARMACEUTICS (2014)
C9ORF72-ALS: P62-AND UBIQUITIN-AGGREGATION PATHOLOGY IN SKELETAL MUSCLE
Matthias Tuerk et al.
MUSCLE & NERVE (2014)
Cargo recognition and trafficking in selective autophagy
Alexandra Stolz et al.
NATURE CELL BIOLOGY (2014)
Autophagy induction enhances TDP43 turnover and survival in neuronal ALS models
Sami J. Barmada et al.
NATURE CHEMICAL BIOLOGY (2014)
Autophagy regulates amyotrophic lateral sclerosis-linked fused in sarcoma-positive stress granules in neurons
Hyun-Hee Ryu et al.
NEUROBIOLOGY OF AGING (2014)
C9orf72 expansions are the most common genetic cause of Huntington disease phenocopies
Davina J. Hensman Moss et al.
NEUROLOGY (2014)
Antisense Proline-Arginine RAN Dipeptides Linked to C9ORF72-ALS/FTD Form Toxic Nuclear Aggregates that Initiate In Vitro and In Vivo Neuronal Death
Xinmei Wen et al.
NEURON (2014)
Loss of mTOR-Dependent Macroautophagy Causes Autistic-like Synaptic Pruning Deficits
Guomei Tang et al.
NEURON (2014)
Autophagy and Protein Turnover Signaling in Slow-Twitch Muscle during Exercise
Allan F. Pagano et al.
MEDICINE & SCIENCE IN SPORTS & EXERCISE (2014)
Schwann cell autophagy counteracts the onset and chronification of neuropathic pain
Sara Marinelli et al.
PAIN (2014)
Transcellular degradation of axonal mitochondria
Chung-ha O. Davis et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Optineurin is an autophagy receptor for damaged mitochondria in parkin-mediated mitophagy that is disrupted by an ALS-linked mutation
Yvette C. Wong et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)
Poly-dipeptides encoded by the C9orf72 repeats bind nucleoli, impede RNA biogenesis, and kill cells
Ilmin Kwon et al.
SCIENCE (2014)
TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis
Gernot Kleinberger et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
Intrinsic Membrane Hyperexcitability of Amyotrophic Lateral Sclerosis Patient-Derived Motor Neurons
Brian J. Wainger et al.
CELL REPORTS (2014)
The Role of the Selective Adaptor p62 and Ubiquitin-Like Proteins in Autophagy
Monika Lippai et al.
BIOMED RESEARCH INTERNATIONAL (2014)
TREM2 Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis
Janet Cady et al.
JAMA NEUROLOGY (2014)
TBK1 Gene Duplication and Normal-Tension Glaucoma
Robert Ritch et al.
JAMA OPHTHALMOLOGY (2014)
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations
Ian R. Mackenzie et al.
ACTA NEUROPATHOLOGICA (2013)
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins
Kohji Mori et al.
ACTA NEUROPATHOLOGICA (2013)
Modeling key pathological features of frontotemporal dementia with C9ORF72 repeat expansion in iPSC-derived human neurons
Sandra Almeida et al.
ACTA NEUROPATHOLOGICA (2013)
Mutations in SQSTM1 encoding p62 in amyotrophic lateral sclerosis: genetics and neuropathology
Elisa Teyssou et al.
ACTA NEUROPATHOLOGICA (2013)
Large C9orf72 Hexanucleotide Repeat Expansions Are Seen in Multiple Neurodegenerative Syndromes and Are More Frequent Than Expected in the UK Population
Jon Beck et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2013)
Adaptive plasticity of autophagic proteins to denervation in aging skeletal muscle
Michael F. O'Leary et al.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2013)
Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state
Cecile Jamart et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2013)
Behavioral effects of SQSTM-1/p62 overexpression in mice: Support for a mitochondrial role in depression and anxiety
M. Lamar Seibenhener et al.
BEHAVIOURAL BRAIN RESEARCH (2013)
The role of TDP-43 in the pathogenesis of ALS and FTLD
Marco Baralle et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2013)
The product of C9orf72, a gene strongly implicated in neurodegeneration, is structurally related to DENN Rab-GEFs
Timothy P. Levine et al.
BIOINFORMATICS (2013)
C9orf72 repeat expansions are a rare genetic cause of parkinsonism
Suzanne Lesage et al.
BRAIN (2013)
Loss of TDP-43 causes age-dependent progressive motor neuron degeneration
Yohei Iguchi et al.
BRAIN (2013)
Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function
J. Ross Buchan et al.
CELL (2013)
Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance
Elisa Motori et al.
CELL METABOLISM (2013)
Corticobasal and ataxia syndromes widen the spectrum of C9ORF72 hexanucleotide expansion disease
S. G. Lindquist et al.
CLINICAL GENETICS (2013)
New Insights Into the Role of Sequestosome 1/p62 Mutant Proteins in the Pathogenesis of Paget's Disease of Bone
Sarah L. Rea et al.
ENDOCRINE REVIEWS (2013)
Role of p62/SQSTM1 in liver physiology and pathogenesis
Sharon Manley et al.
EXPERIMENTAL BIOLOGY AND MEDICINE (2013)
Adverse events associated with mTOR inhibitors
Nicolas Pallet et al.
EXPERT OPINION ON DRUG SAFETY (2013)
Non-canonical IKKs, IKKε and TBK1, as novel therapeutic targets in the treatment of non-small cell lung cancer
Jae-Young Kim et al.
EXPERT OPINION ON THERAPEUTIC TARGETS (2013)
mTOR kinase, a key player in the regulation of glial functions: Relevance for the therapy of multiple sclerosis
Cinzia Dello Russo et al.
GLIA (2013)
Increased miR-195 aggravates neuropathic pain by inhibiting autophagy following peripheral nerve injury
Guodong Shi et al.
GLIA (2013)
Disease Animal Models of TDP-43 Proteinopathy and Their Pre-Clinical Applications
Yu-Chih Liu et al.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2013)
Ubiquitin-independent function of optineurin in autophagic clearance of protein aggregates
Jelena Korac et al.
JOURNAL OF CELL SCIENCE (2013)
Optineurin suppression causes neuronal cell death via NF-κB pathway
Mayumi Akizuki et al.
JOURNAL OF NEUROCHEMISTRY (2013)
Autophagy Promotes Oligodendrocyte Survival and Function following Dysmyelination in a Long-Lived Myelin Mutant
Chelsey M. Smith et al.
JOURNAL OF NEUROSCIENCE (2013)
Autophagic response to exercise training in skeletal muscle with age
Yong An Kim et al.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY (2013)
Skeletal Muscle Autophagy and Protein Breakdown Following Resistance Exercise are Similar in Younger and Older Adults
Christopher S. Fry et al.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES (2013)
Inhibition of Nonsense-Mediated RNA Decay Activates Autophagy
Jordan Wengrod et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
K63 Polyubiquitination and Activation of mTOR by the p62-TRAF6 Complex in Nutrient-Activated Cells
Juan F. Linares et al.
MOLECULAR CELL (2013)
Lithium in patients with amyotrophic lateral sclerosis (LiCALS): a phase 3 multicentre, randomised, double-blind, placebo-controlled trial
LANCET NEUROLOGY (2013)
Overexpression of ALS-Associated p.M337V Human TDP-43 in Mice Worsens Disease Features Compared to Wild-type Human TDP-43 Mice
Jonathan Janssens et al.
MOLECULAR NEUROBIOLOGY (2013)
Selective Forelimb Impairment in Rats Expressing a Pathological TDP-43 25 kDa C-terminal Fragment to Mimic Amyotrophic Lateral Sclerosis
Robert D. Dayton et al.
MOLECULAR THERAPY (2013)
Identification of a candidate therapeutic autophagy-inducing peptide
Sanae Shoji-Kawata et al.
NATURE (2013)
Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS
Hong Joo Kim et al.
NATURE (2013)
The autophagosome: origins unknown, biogenesis complex
Christopher A. Lamb et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2013)
Screening for rare variants in the coding region of ALS-associated genes at 9p21.2 and 19p13.3
Max Koppers et al.
NEUROBIOLOGY OF AGING (2013)
C9orf72 G4C2 repeat expansions in Alzheimer's disease and mild cognitive impairment
Rita Cacace et al.
NEUROBIOLOGY OF AGING (2013)
Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS
Peter E. A. Ash et al.
NEURON (2013)
RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
Christopher J. Donnelly et al.
NEURON (2013)
Microglial Beclin 1 Regulates Retromer Trafficking and Phagocytosis and Is Impaired in Alzheimer's Disease
Kurt M. Lucin et al.
NEURON (2013)
Converging Mechanisms in ALS and FTD: Disrupted RNA and Protein Homeostasis
Shuo-Chien Ling et al.
NEURON (2013)
Deletion of C9ORF72 Results in Motor Neuron Degeneration and Stress Sensitivity in C-elegans
Martine Therrien et al.
PLOS ONE (2013)
Exercise Training Reverses Skeletal Muscle Atrophy in an Experimental Model of VCP Disease
Angele Nalbandian et al.
PLOS ONE (2013)
Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy
Andrea Serio et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
Eveline S. Arnold et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis
Amanda Sierra et al.
FRONTIERS IN CELLULAR NEUROSCIENCE (2013)
Frontotemporal dementia, Parkinsonism and lower motor neuron involvement in a patient with C9ORF72 expansion
Marco Luigetti et al.
AMYOTROPHIC LATERAL SCLEROSIS AND FRONTOTEMPORAL DEGENERATION (2013)
C9orf72 Hexanucleotide Repeat Expansions in Clinical Alzheimer Disease
Matthew Harms et al.
JAMA NEUROLOGY (2013)
Uptake and mitochondrial dysfunction of alpha-synuclein in human astrocytes, cortical neurons and fibroblasts
Nady Braidy et al.
TRANSLATIONAL NEURODEGENERATION (2013)
Dipeptide repeat proteins are present in the p62 positive inclusions in patients with frontotemporal lobar degeneration and motor neurone disease associated with expansions in C9ORF72
David M. A. Mann et al.
ACTA NEUROPATHOLOGICA COMMUNICATIONS (2013)
Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction
Ashley Cannon et al.
ACTA NEUROPATHOLOGICA (2012)
Rapamycin prevents the mutant huntingtin-suppressed GLT-1 expression in cultured astrocytes
Lei-lei Chen et al.
ACTA PHARMACOLOGICA SINICA (2012)
Cognitive Decline Typical of Frontotemporal Lobar Degeneration in Transgenic Mice Expressing the 25-kDa C-Terminal Fragment of TDP-43
Antonella Caccamo et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
AMPK Activation Stimulates Autophagy and Ameliorates Muscular Dystrophy in the mdx Mouse Diaphragm
Marion Pauly et al.
AMERICAN JOURNAL OF PATHOLOGY (2012)
Autophagosome assembly and cargo capture in the distal axon
Sandra Maday et al.
AUTOPHAGY (2012)
Progressive neuronal inclusion formation and axonal degeneration in CHMP2B mutant transgenic mice
Shabnam Ghazi-Noori et al.
BRAIN (2012)
Non-human primate model of amyotrophic lateral sclerosis with cytoplasmic mislocalization of TDP-43
Azusa Uchida et al.
BRAIN (2012)
mTOR Signaling in Growth Control and Disease
Mathieu Laplante et al.
CELL (2012)
Toward an integrative view of Optineurin functions
David Kachaner et al.
CELL CYCLE (2012)
Microautophagy: lesser-known self-eating
Wen-wen Li et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2012)
Nuclear factor k B expression in patients with sporadic amyotrophic lateral sclerosis and hereditary amyotrophic lateral sclerosis with optineurin mutations
Wataru Sako et al.
CLINICAL NEUROPATHOLOGY (2012)
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS
Dorothee Dormann et al.
EMBO JOURNAL (2012)
Autophagy-related and autophagy-regulatory genes are induced in human muscle after ultraendurance exercise
Cecile Jamart et al.
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY (2012)
Wild type TDP-43 induces neuro-inflammation and alters APP metabolism in lentiviral gene transfer models
Alexander M. Herman et al.
EXPERIMENTAL NEUROLOGY (2012)
Frontotemporal lobar degeneration-related proteins induce only subtle memory-related deficits when bilaterally overexpressed in the dorsal hippocampus
Robert D. Dayton et al.
EXPERIMENTAL NEUROLOGY (2012)
TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
Manohar Pilli et al.
IMMUNITY (2012)
Modulation of autophagy and ubiquitin-proteasome pathways during ultra-endurance running
Cecile Jamart et al.
JOURNAL OF APPLIED PHYSIOLOGY (2012)
Autophagy Suppresses Interleukin-1β (IL-1β) Signaling by Activation of p62 Degradation via Lysosomal and Proteasomal Pathways
Jongdae Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Cdc37/Hsp90 Protein Complex Disruption Triggers an Autophagic Clearance Cascade for TDP-43 Protein
Umesh K. Jinwal et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Targeted Depletion of TDP-43 Expression in the Spinal Cord Motor Neurons Leads to the Development of Amyotrophic Lateral Sclerosis-like Phenotypes in Mice
Lien-Szu Wu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Autophagosomes initiate distally and mature during transport toward the cell soma in primary neurons
Sandra Maday et al.
JOURNAL OF CELL BIOLOGY (2012)
Mutant TDP-43 in motor neurons promotes the onset and progression of ALS in rats
Cao Huang et al.
JOURNAL OF CLINICAL INVESTIGATION (2012)
Heterozygous TBK1 mutations impair TLR3 immunity and underlie herpes simplex encephalitis of childhood
Melina Herman et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Lithium lacks effect on survival in amyotrophic lateral sclerosis: a phase IIb randomised sequential trial
Esther Verstraete et al.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY (2012)
C9ORF72 expansion in amyotrophic lateral sclerosis/frontotemporal dementia also causes parkinsonism
Sean O'Dowd et al.
MOVEMENT DISORDERS (2012)
Oligodendroglia metabolically support axons and contribute to neurodegeneration
Youngjin Lee et al.
NATURE (2012)
Exercise-induced BCL2-regulated autophagy is required for muscle glucose homeostasis
Congcong He et al.
NATURE (2012)
Emerging functions of the VCP/p97 AAA-ATPase in the ubiquitin system
Hemmo Meyer et al.
NATURE CELL BIOLOGY (2012)
Mutations in UBQLN2 are rare in French amyotrophic lateral sclerosis
Stephanie Millecamps et al.
NEUROBIOLOGY OF AGING (2012)
UBQLN2 mutations are rare in French and French-Canadian amyotrophic lateral sclerosis
Hussein Daoud et al.
NEUROBIOLOGY OF AGING (2012)
FUS and TDP43 genetic variability in FTD and CBS
Edward D. Huey et al.
NEUROBIOLOGY OF AGING (2012)
SQSTM1 mutations in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Elisa Rubino et al.
NEUROLOGY (2012)
An MND/ALS phenotype associated with C9orf72 repeat expansion: Abundant p62-positive, TDP-43-negative inclusions in cerebral cortex, hippocampus and cerebellum but without associated cognitive decline
Claire Troakes et al.
NEUROPATHOLOGY (2012)
Microglial Activation Correlates with Disease Progression and Upper Motor Neuron Clinical Symptoms in Amyotrophic Lateral Sclerosis
Johannes Brettschneider et al.
PLOS ONE (2012)
The Homozygote VCPR155H/R155H Mouse Model Exhibits Accelerated Human VCP-Associated Disease Pathology
Angele Nalbandian et al.
PLOS ONE (2012)
Molecular Imaging of Microglial Activation in Amyotrophic Lateral Sclerosis
Philippe Corcia et al.
PLOS ONE (2012)
Autophagy and Apoptosis Are Differentially Induced in Neurons and Astrocytes Treated with an In Vitro Mimic of the Ischemic Penumbra
Matthew E. Pamenter et al.
PLOS ONE (2012)
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
Bilada Bilican et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43
I-Fang Wang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation
Richard C. Wang et al.
SCIENCE (2012)
P-Bodies and Stress Granules: Possible Roles in the Control of Translation and mRNA Degradation
Carolyn J. Decker et al.
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)
Slow development of ALS-like spinal cord pathology in mutant valosin-containing protein gene knock-in mice
H. Z. Yin et al.
CELL DEATH & DISEASE (2012)
Longitudinal neuroimaging and neuropsychological profiles of frontotemporal dementia with C9ORF72 expansions
Colin J. Mahoney et al.
ALZHEIMERS RESEARCH & THERAPY (2012)
PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65
Chandana Kondapalli et al.
OPEN BIOLOGY (2012)
Discovery of Novel DENN Proteins: Implications for the Evolution of Eukaryotic Intracellular Membrane Structures and Human Disease
Dapeng Zhang et al.
Frontiers in Genetics (2012)
Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation
Ian R. A. Mackenzie et al.
ACTA NEUROPATHOLOGICA (2011)
p62 positive, TDP-43 negative, neuronal cytoplasmic and intranuclear inclusions in the cerebellum and hippocampus define the pathology of C9orf72-linked FTLD and MND/ALS
Safa Al-Sarraj et al.
ACTA NEUROPATHOLOGICA (2011)
Biogenesis and Cargo Selectivity of Autophagosomes
Hilla Weidberg et al.
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 80 (2011)
Ultrastructural Mitochondrial Abnormalities in Patients With Sporadic Amyotrophic Lateral Sclerosis
Laura Napoli et al.
ARCHIVES OF NEUROLOGY (2011)
Differential Involvement of Optineurin in Amyotrophic Lateral Sclerosis With or Without SOD1 Mutations
Han-Xiang Deng et al.
ARCHIVES OF NEUROLOGY (2011)
SQSTM1 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
Faisal Fecto et al.
ARCHIVES OF NEUROLOGY (2011)
Selective autophagy mediated by autophagic adapter proteins
Terje Johansen et al.
AUTOPHAGY (2011)
V-ATPase engagement in autophagic processes
Dalibor Mijaljica et al.
AUTOPHAGY (2011)
Rapamycin treatment augments motor neuron degeneration in SOD1G93A mouse model of amyotrophic lateral sclerosis
Xiaojie Zhang et al.
AUTOPHAGY (2011)
Pathological hallmarks of amyotrophic lateral sclerosis/frontotemporal lobar degeneration in transgenic mice produced with TDP-43 genomic fragments
Vivek Swarup et al.
BRAIN (2011)
Autophagy: Renovation of Cells and Tissues
Noboru Mizushima et al.
CELL (2011)
Mammalian Target of Rapamycin (mTOR) Inhibitors Potential Uses and a Review of Haematological Adverse Effects
Sofia Sofroniadou et al.
DRUG SAFETY (2011)
A point mutation in the ubiquitin-associated domain of SQSMT1 is sufficient to cause a Paget's disease-like disorder in mice
Anna Daroszewska et al.
HUMAN MOLECULAR GENETICS (2011)
TDP-43 Potentiates Alpha-synuclein Toxicity to Dopaminergic Neurons in Transgenic Mice
Tian Tian et al.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES (2011)
Targeting Oligomers in Neurodegenerative Disorders: Lessons from α-Synuclein, Tau, and Amyloid-β Peptide
Bharathi Shrikanth Gadad et al.
JOURNAL OF ALZHEIMERS DISEASE (2011)
Regulation of Autophagy by Neuropathological Protein TDP-43
Jayarama Krishnan Bose et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Dynamics of the Degradation of Ubiquitinated Proteins by Proteasomes and Autophagy ASSOCIATION WITH SEQUESTOSOME 1/p62
Natura Myeku et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Crystal Structure of the Ubiquitin-associated (UBA) Domain of p62 and Its Interaction with Ubiquitin
Shin Isogai et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
The regulation of autophagy - unanswered questions
Yongqiang Chen et al.
JOURNAL OF CELL SCIENCE (2011)
Cytoplasmic mRNP granules at a glance
Stacy L. Erickson et al.
JOURNAL OF CELL SCIENCE (2011)
Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice
Lionel M. Igaz et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Induction of autophagy with catalytic mTOR inhibitors reduces huntingtin aggregates in a neuronal cell model
Ana Roscic et al.
JOURNAL OF NEUROCHEMISTRY (2011)
Autophagy in Spinal Cord Motor Neurons in Sporadic Amyotrophic Lateral Sclerosis
Shoichi Sasaki
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2011)
c-Jun expression in human neuropathies: a pilot study
Elspeth J. Hutton et al.
JOURNAL OF THE PERIPHERAL NERVOUS SYSTEM (2011)
p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
Angeles Duran et al.
MOLECULAR CELL (2011)
Neuroinflammation in amyotrophic lateral sclerosis: role of glial activation in motor neuron disease
Thomas Philips et al.
LANCET NEUROLOGY (2011)
Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
Ya-Fei Xu et al.
MOLECULAR NEURODEGENERATION (2011)
Mutations in UBQLN2 cause dominant X-linked juvenile and adult-onset ALS and ALS/dementia
Han-Xiang Deng et al.
NATURE (2011)
Astrocytes from familial and sporadic ALS patients are toxic to motor neurons
Amanda M. Haidet-Phillips et al.
NATURE BIOTECHNOLOGY (2011)
TDP-43-Based Animal Models of Neurodegeneration: New Insights into ALS Pathology and Pathophysiology
Iga Wegorzewska et al.
NEURODEGENERATIVE DISEASES (2011)
NOVEL p.Ile151Val MUTATION IN VCP IN A PATIENT OF AFRICAN AMERICAN DESCENT WITH SPORADIC ALS
M. DeJesus-Hernandez et al.
NEUROLOGY (2011)
Phase II screening trial of lithium carbonate in amyotrophic lateral sclerosis Examining a more efficient trial design
R. G. Miller et al.
NEUROLOGY (2011)
Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
Mariely DeJesus-Hernandez et al.
NEURON (2011)
A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
Alan E. Renton et al.
NEURON (2011)
Functional Dissection of the TBK1 Molecular Network
Adriana Goncalves et al.
PLOS ONE (2011)
Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo
Sophia T. Papadeas et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Phosphorylation of the Autophagy Receptor Optineurin Restricts Salmonella Growth
Philipp Wild et al.
SCIENCE (2011)
TFEB Links Autophagy to Lysosomal Biogenesis
Carmine Settembre et al.
SCIENCE (2011)
Astrocytes: biology and pathology
Michael V. Sofroniew et al.
ACTA NEUROPATHOLOGICA (2010)
Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis
Brian C. Kraemer et al.
ACTA NEUROPATHOLOGICA (2010)
Characterization of autophagosome formation site by a hierarchical analysis of mammalian Atg proteins
Eisuke Itakura et al.
AUTOPHAGY (2010)
A role of small heat shock protein B8 (HspB8) in the autophagic removal of misfolded proteins responsible for neurodegenerative diseases
Valeria Crippa et al.
AUTOPHAGY (2010)
VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD
Emilie Tresse et al.
AUTOPHAGY (2010)
FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging
Fabio Demontis et al.
CELL (2010)
Cdc48 and Ufd3, new partners of the ubiquitin protease Ubp3, are required for ribophagy
Batool Ossareh-Nazari et al.
EMBO REPORTS (2010)
Regulation of autophagy by phosphatidylinositol 3-phosphate
Chloe Burman et al.
FEBS LETTERS (2010)
Autophagy Is Activated by Proteasomal Inhibition and Involved in Aggresome Clearance in Cultured Astrocytes
Sven B. Jaenen et al.
GLIA (2010)
Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone
Sara K. Custer et al.
HUMAN MOLECULAR GENETICS (2010)
Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy
Cara Rothenberg et al.
HUMAN MOLECULAR GENETICS (2010)
TDP-43 Is a Developmentally Regulated Protein Essential for Early Embryonic Development
Chantelle F. Sephton et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
Ashish Jain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
He-Jin Lee et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U
Kuen-Jer Tsai et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2010)
Dimerisation of the UBA Domain of p62 Inhibits Ubiquitin Binding and Regulates NF-κB Signalling
Jed Long et al.
JOURNAL OF MOLECULAR BIOLOGY (2010)
Endoplasmic Reticulum Stress in Motor Neurons of the Spinal Cord in Sporadic Amyotrophic Lateral Sclerosis
Shoichi Sasaki
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY (2010)
Cytoplasmic Mislocalization of TDP-43 Is Toxic to Neurons and Enhanced by a Mutation Associated with Familial Amyotrophic Lateral Sclerosis
Sami J. Barmada et al.
JOURNAL OF NEUROSCIENCE (2010)
Wild-Type Human TDP-43 Expression Causes TDP-43 Phosphorylation, Mitochondrial Aggregation, Motor Deficits, and Early Mortality in Transgenic Mice
Ya-Fei Xu et al.
JOURNAL OF NEUROSCIENCE (2010)
Autophagy and the Integrated Stress Response
Guido Kroemer et al.
MOLECULAR CELL (2010)
Safety and efficacy of lithium in combination with riluzole for treatment of amyotrophic lateral sclerosis: a randomised, double-blind, placebo-controlled trial
Swati P. Aggarwal et al.
LANCET NEUROLOGY (2010)
The mTOR kinase inhibitor Everolimus decreases S6 kinase phosphorylation but fails to reduce mutant huntingtin levels in brain and is not neuroprotective in the R6/2 mouse model of Huntington's disease
Jonathan H. Fox et al.
MOLECULAR NEURODEGENERATION (2010)
Expansive Gene Transfer in the Rat CNS Rapidly Produces Amyotrophic Lateral Sclerosis Relevant Sequelae When TDP-43 is Overexpressed
David B. Wang et al.
MOLECULAR THERAPY (2010)
Mutations of optineurin in amyotrophic lateral sclerosis
Hirofumi Maruyama et al.
NATURE (2010)
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
Masaaki Komatsu et al.
NATURE CELL BIOLOGY (2010)
PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1
Sven Geisler et al.
NATURE CELL BIOLOGY (2010)
Progressive motor weakness in transgenic mice expressing human TDP-43
Nancy R. Stallings et al.
NEUROBIOLOGY OF DISEASE (2010)
Lithium carbonate in amyotrophic lateral sclerosis Lack of efficacy in a dose-finding trial
A. Chio et al.
NEUROLOGY (2010)
Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS
Jane O. Johnson et al.
NEURON (2010)
Degradation of TDP-43 and its pathogenic form by autophagy and the ubiquitin-proteasome system
Xiaoju Wang et al.
NEUROSCIENCE LETTERS (2010)
17-AAG Induces Cytoplasmic α-Synuclein Aggregate Clearance by Induction of Autophagy
Michael Riedel et al.
PLOS ONE (2010)
Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)
Laura E. Cox et al.
PLOS ONE (2010)
Ablation of Dicer from Murine Schwann Cells Increases Their Proliferation while Blocking Myelination
Juliane Bremer et al.
PLOS ONE (2010)
A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model
Andrey S. Tsvetkov et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Deletion of TDP-43 down-regulates Tbc1d1, a gene linked to obesity, and alters body fat metabolism
Po-Min Chiang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice
Xiu Shan et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
TDP-43 transgenic mice develop spastic paralysis and neuronal inclusions characteristic of ALS and frontotemporal lobar degeneration
Hans Wils et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
Transgenic Rat Model of Neurodegeneration Caused by Mutation in the TDP Gene
Hongxia Zhou et al.
PLOS GENETICS (2010)
Accumulation of TDP-43 and α-actin in an amyotrophic lateral sclerosis patient with the K17I ANG mutation
Danielle Seilhean et al.
ACTA NEUROPATHOLOGICA (2009)
Deleterious Variants of FIG4. a Phosphoinositide Phosphatase, in Patients with ALS
Clement Y. Chow et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2009)
Evolution and assembly of ESCRTs
Sara Ghazi-Tabatabai et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
p62 at the Crossroads of Autophagy, Apoptosis, and Cancer
Jorge Moscat et al.
CELL (2009)
Autophagy Is Required to Maintain Muscle Mass
Eva Masiero et al.
CELL METABOLISM (2009)
High-content screening of primary neurons: ready for prime time
Aaron Daub et al.
CURRENT OPINION IN NEUROBIOLOGY (2009)
Control of autophagy initiation by phosphoinositide 3-phosphatase jumpy
Isabelle Vergne et al.
EMBO JOURNAL (2009)
PLIC proteins or ubiquilins regulate autophagy-dependent cell survival during nutrient starvation
Elsa-Noah N'Diaye et al.
EMBO REPORTS (2009)
XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
Claudio Hetz et al.
GENES & DEVELOPMENT (2009)
Binding and Uptake of Aβ1-42 by Primary Human Astrocytes In Vitro
Henrietta M. Nielsen et al.
GLIA (2009)
Rapamycin Rescues TDP-43 Mislocalization and the Associated Low Molecular Mass Neurofilament Instability
Antonella Caccamo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
ULK1•ATG13•FIP200 Complex Mediates mTOR Signaling and Is Essential for Autophagy
Ian G. Ganley et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Autophagy promotes synapse development in Drosophila
Wei Shen et al.
JOURNAL OF CELL BIOLOGY (2009)
Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
Jeong-Sun Ju et al.
JOURNAL OF CELL BIOLOGY (2009)
The Adaptor Protein p62/SQSTM1 Targets Invading Bacteria to the Autophagy Pathway
Yiyu T. Zheng et al.
JOURNAL OF IMMUNOLOGY (2009)
Microglia in ALS: The Good, The Bad, and The Resting
Jenny S. Henkel et al.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY (2009)
Activation of the Mammalian Target of Rapamycin (mTOR) Is Essential for Oligodendrocyte Differentiation
William A. Tyler et al.
JOURNAL OF NEUROSCIENCE (2009)
Nutrient-dependent mTORC1 Association with the ULK1-Atg13-FIP200 Complex Required for Autophagy
Nao Hosokawa et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery
Chang Hwa Jung et al.
MOLECULAR BIOLOGY OF THE CELL (2009)
Mimicking Aspects of Frontotemporal Lobar Degeneration and Lou Gehrig's Disease in Rats via TDP-43 Overexpression
Jason B. Tatom et al.
MOLECULAR THERAPY (2009)
Oxidative damage to the promoter region of SQSTM1/p62 is common to neurodegenerative disease
Yifeng Du et al.
NEUROBIOLOGY OF DISEASE (2009)
Involvement of CHOP, an ER-stress apoptotic mediator, in both human sporadic ALS and ALS model mice
Yasushi Ito et al.
NEUROBIOLOGY OF DISEASE (2009)
被撤回的出版物: Increased muscle PGC-1 alpha expression protects from sarcopenia and metabolic disease during aging(Retracted article. See vol.113,pg.E8502,2016)
Tina Wenz et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
Iga Wegorzewska et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
A Gene Network Regulating Lysosomal Biogenesis and Function
Marco Sardiello et al.
SCIENCE (2009)
White matter lesions in the brain with frontotemporal lobar degeneration with motor neuron disease: TDP-43-immunopositive inclusions co-localize with p62, but not ubiquitin
Masanori Hiji et al.
ACTA NEUROPATHOLOGICA (2008)
Sporadic amyotrophic lateral sclerosis: two pathological patterns shown by analysis of distribution of TDP-43-immunoreactive neuronal and glial cytoplasmic inclusions
Yasushi Nishihira et al.
ACTA NEUROPATHOLOGICA (2008)
TDP-43 mutation in familial amyotrophic lateral sclerosis
Akio Yokoseki et al.
ANNALS OF NEUROLOGY (2008)
Autophagy and amyotrophic lateral sclerosis: The multiple roles of lithium
Francesco Fornai et al.
AUTOPHAGY (2008)
Roles of VCP in human neurodegenerative disorders
Akira Kakizuka
BIOCHEMICAL SOCIETY TRANSACTIONS (2008)
Autophagy and the ubiquitin-proteasome system: Collaborators in neuroprotection
Natalia B. Nedelsky et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2008)
The signaling adaptor p62 is an important NF-κB mediator in tumorigenesis
Angeles Duran et al.
CANCER CELL (2008)
Autophagy in the pathogenesis of disease
Beth Levine et al.
CELL (2008)
Skeletal Muscle Is a Primary Target of SOD1G93A-Mediated Toxicity
Gabriella Dobrowolny et al.
CELL METABOLISM (2008)
The Atg8 and Atg12 ubiquitin-like conjugation systems in macroautophagy
Jiefei Geng et al.
EMBO REPORTS (2008)
Autophagy induced by Alexander disease-mutant GFAP accumulation is regulated by p38/MAPK and mTOR signaling pathways
Guomei Tang et al.
HUMAN MOLECULAR GENETICS (2008)
Suppression of autophagy in skeletal muscle uncovers the accumulation of ubiquitinated proteins and their potential role in muscle damage in Pompe disease
Nina Raben et al.
HUMAN MOLECULAR GENETICS (2008)
Structural basis for sorting mechanism of p62 in selective autophagy
Yoshinobu Ichimura et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Autophagy induction and autophagosome clearance in neurons: Relationship to autophagic pathology in Alzheimer's disease
Barry Boland et al.
JOURNAL OF NEUROSCIENCE (2008)
Nrf2 Activation in Astrocytes Protects against Neurodegeneration in Mouse Models of Familial Amyotrophic Lateral Sclerosis
Marcelo R. Vargas et al.
JOURNAL OF NEUROSCIENCE (2008)
Constitutive activation of chaperone-mediated autophagy in cells with impaired macroautophagy
Susmita Kaushik et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
Beclin 1 Forms Two Distinct Phosphatidylinositol 3-Kinase Complexes with Mammalian Atg14 and UVRAG
Eisuke Itakura et al.
MOLECULAR BIOLOGY OF THE CELL (2008)
JNK1-mediated phosphorylation of BcI-2 regulates starvation-induced autophagy
Yongjie Wei et al.
MOLECULAR CELL (2008)
TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology:: a genetic and histopathological analysis
Vivianna M. Van Deerlin et al.
LANCET NEUROLOGY (2008)
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
Tatsuya Saitoh et al.
NATURE (2008)
Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking
Chengyu Liang et al.
NATURE CELL BIOLOGY (2008)
TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
Edor Kabashi et al.
NATURE GENETICS (2008)
Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease
Angelo C. Lepore et al.
NATURE NEUROSCIENCE (2008)
Astrocytes as determinants of disease progression in inherited amyotrophic lateral sclerosis
Koji Yamanaka et al.
NATURE NEUROSCIENCE (2008)
Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis
Julie D. Atkin et al.
NEUROBIOLOGY OF DISEASE (2008)
Lithium delays progression of amyotrophic lateral sclerosis
Francesco Fornai et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or inhibit fusion in Drosophila
Hansong Deng et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Autophagy is essential for preimplantation development of mouse embryos
Satoshi Tsukamoto et al.
SCIENCE (2008)
TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis
Jemeen Sreedharan et al.
SCIENCE (2008)
CHMP2B C-truncating mutations in frontotemporal lobar degeneration are associated with an aberrant endosomal phenotype in vitro
Julie van der Zee et al.
HUMAN MOLECULAR GENETICS (2008)
TDP-43-immunoreactive neuronal and glial inclusions in the neostriatum in amyotrophic lateral sclerosis with and without dementia
Haixin Zhang et al.
ACTA NEUROPATHOLOGICA (2008)
FoxO3 controls autophagy in skeletal muscle in vivo
Cristina Mammucari et al.
CELL METABOLISM (2007)
Oxidative and endoplasmic reticulum stress interplay in sporadic amyotrophic lateral sclerosis
Ekaterina V. Ilieva et al.
BRAIN (2007)
Functional multivesicular bodies are required for autophagic clearance of protein aggregates associated with neurodegenerative disease
Maria Filimonenko et al.
JOURNAL OF CELL BIOLOGY (2007)
ESCRT-III dysfunction causes autophagosome accumulation and neurodegeneration
Jin-A Lee et al.
CURRENT BIOLOGY (2007)
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
Nobutoshi Morimoto et al.
BRAIN RESEARCH (2007)
Essential role for autophagy protein Atg7 in the maintenance of axonal homeostasis and the prevention of axonal degeneration
Masaaki Komatsu et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Optineurin negatively regulates TNFα-induced NF-κB activation by competing with NEMO for ubiquitinated RIP
Guozhi Zhu et al.
CURRENT BIOLOGY (2007)
p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy
Serhiy Pankiv et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Ambra1 regulates autophagy and development of the nervous system
Gian Maria Fimia et al.
NATURE (2007)
Small molecules enhance autophagy and reduce toxicity in Huntington's disease models
Sovan Sarkar et al.
NATURE CHEMICAL BIOLOGY (2007)
Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations
Ian R. A. Mackenzie et al.
ANNALS OF NEUROLOGY (2007)
Pathological consequences of VCP mutations on human striated muscle
Christian U. Huebbers et al.
BRAIN (2007)
Mutation of the sequestosome 1 (p62) gene increases osteoclastogenesis but does not induce Paget disease
Noriyoshi Kurihara et al.
JOURNAL OF CLINICAL INVESTIGATION (2007)
TDP-43 is a component of ubiquitin-positive tau-negative inclusions in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Tetsuaki Arai et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2006)
Immunoreactivities of p62, an ubiqutin-binding protein, in the spinal anterior horn cells of patients with amyotrophic lateral sclerosis
Yuji Mizuno et al.
JOURNAL OF THE NEUROLOGICAL SCIENCES (2006)
Transgenic mouse models of amyotrophic lateral sclerosis
Jean-Pierre Julien et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2006)
Wild-type microglia extend survival in PU.1 knockout mice with familial amyotrophic lateral sclerosis
David R. Beers et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Role of FIP200 in cardiac and liver development and its regulation of TNFα and TSC-mTOR signaling pathways
Boyi Gan et al.
JOURNAL OF CELL BIOLOGY (2006)
Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis
Manuela Neumann et al.
SCIENCE (2006)
ALS phenotypes with mutations in CHMP2B (charged multivesicular body protein 2B)
N. Parkinson et al.
NEUROLOGY (2006)
Induction of autophagy in axonal dystrophy and degeneration
Qing Jun Wang et al.
JOURNAL OF NEUROSCIENCE (2006)
Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused inactivation of Drosophila Pink1 is rescued by by Parkin
Yufeng Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
p97: The cell's molecular purgatory?
Dalia Halawani et al.
MOLECULAR CELL (2006)
Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice
Taichi Hara et al.
NATURE (2006)
Loss of autophagy in the central nervous system causes neurodegeneration in mice
Masaaki Komatsu et al.
NATURE (2006)
Regulation of autophagy by sphingosine kinase 1 and its role in cell survival during nutrient starvation
G Lavieu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62
A Rodriguez et al.
CELL METABOLISM (2006)
Autophagy: molecular machinery for self-eating
T Yorimitsu et al.
CELL DEATH AND DIFFERENTIATION (2005)
Treatment of hepatocellular carcinoma with adenoviral vector-mediated Flt3 ligand gene therapy
H Wang et al.
CANCER GENE THERAPY (2005)
Mutations in the endosomal ESCRTIII-complex subunit CHMP2B in frontotemporal dementia
G Skibinski et al.
NATURE GENETICS (2005)
Runx1 prevents wasting, myofibrillar disorganization, and autophagy of skeletal muscle
XX Wang et al.
GENES & DEVELOPMENT (2005)
Mutant valosin-containing protein causes a novel type of frontotemporal dementia
R Schröder et al.
ANNALS OF NEUROLOGY (2005)
Inclusion body myopathy associated with Paget disease of bone and frontotemporal dementia is caused by mutant valosin-containing protein
GDJ Watts et al.
NATURE GENETICS (2004)
Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis:: an [11C](R)-PK11195 positron emission tomography study
MR Turner et al.
NEUROBIOLOGY OF DISEASE (2004)
In vivo analysis of autophagy in response to nutrient starvation using transgenic mice expressing a fluorescent autophagosome marker
N Mizushima et al.
MOLECULAR BIOLOGY OF THE CELL (2004)
The atypical PKC-interacting protein p62 is an important mediator of RANK-activated osteoclastogenesis
A Durán et al.
DEVELOPMENTAL CELL (2004)
Glial cells
KR Jessen
INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY (2004)
Sequestosome 1/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasome degradation
ML Seibenhener et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
The role of autophagy during the early neonatal starvation period
A Kuma et al.
NATURE (2004)
Protein aggregation and neurodegenerative disease
CA Ross et al.
NATURE MEDICINE (2004)
Apolipoprotein E promotes astrocyte colocalization and degradation of deposited amyloid-β peptides
M Koistinaho et al.
NATURE MEDICINE (2004)
Ubiquitin family proteins and their relationship to the proteasome: a structural perspective
KJ Walters et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2004)
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
ZY Yue et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
Neuronal and glial inclusions in frontotemporal dementia with or without motor neuron disease are immunopositive for p62
T Arai et al.
NEUROSCIENCE LETTERS (2003)
Adult mouse astrocytes degrade amyloid-β in vitro and in situ
T Wyss-Coray et al.
NATURE MEDICINE (2003)
Biomedicine - Toxic proteins in neurodegenerative disease
JP Taylor et al.
SCIENCE (2002)
Recurrent mutation of the gene encoding sequestosome 1 (SQSTM1/p62) in Paget disease of bone
N Laurin et al.
AMERICAN JOURNAL OF HUMAN GENETICS (2002)
VCP (p97) regulates NF kappa B signaling pathway, which IS important for metastasis of osteosarcoma cell line
T Asai et al.
JAPANESE JOURNAL OF CANCER RESEARCH (2002)
p62 is a common component of cytoplasmic inclusions in protein aggregation diseases
K Zatloukal et al.
AMERICAN JOURNAL OF PATHOLOGY (2002)
Ultrastructural changes of mitochondria in the skeletal muscle of patients with amyotrophic lateral sclerosis
MJ Chung et al.
ULTRASTRUCTURAL PATHOLOGY (2002)
Ubiquitin-binding protein p62 expression is induced during apoptosis and proteasomal inhibition in neuronal cells
E Kuusisto et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2001)
New component of the vacuolar class C-Vps complex couples nucleotide exchange on the Ypt7 GTPase to SNARE-dependent docking and fusion
AE Wurmser et al.
JOURNAL OF CELL BIOLOGY (2000)
Therapeutic drug monitoring of sirolimus: correlations with efficacy and toxicity
BD Kahan et al.
CLINICAL TRANSPLANTATION (2000)
Restricted expression of G86R Cu/Zn superoxide dismutase in astrocytes results in astrocytosis but does not cause motoneuron degeneration
YH Gong et al.
JOURNAL OF NEUROSCIENCE (2000)
Share Paper
