Journal
EXPERIMENTAL CELL RESEARCH
Volume 343, Issue 1, Pages 35-41Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2015.10.027
Keywords
Integrin; Talin; Paxillin; FAK; Fibronectin; Conformation
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Funding
- Academy of Finland [290506, 136288]
- Swiss Foundation for Research on Myopathies
- Swiss National Science Foundation [31003A-130742]
- Ligue Genevoise contre le Cancer
- Swiss National Science Foundation (SNF) [31003A_130742] Funding Source: Swiss National Science Foundation (SNF)
- Academy of Finland (AKA) [136288, 136288] Funding Source: Academy of Finland (AKA)
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Cell-matrix adhesions have since long been recognized to be critical for the survival and proliferation of cells. In fact, these adhesive structures do not only physically anchor cells, but they also induce vital intracellular signaling at cell-matrix adhesion sites. Recent progress in the cell adhesion field is now starting to provide data and ideas how this so far enigmatic signaling process is induced and regulated by intracellular acto-myosin tension, or stiffness of the extracellular matrix. Understanding how cells are using this mechanosignaling system will be key to control biological processes such as development, cancer growth, metastasis formation and tissue regeneration. In this review, we illustrate and discuss the mechanosignaling mechanisms important in the regulation of cell-matrix adhesions at the molecular level. (C) 2015 Elsevier Inc. All rights reserved.
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