Journal
EXPERIMENTAL CELL RESEARCH
Volume 343, Issue 1, Pages 73-81Publisher
ELSEVIER INC
DOI: 10.1016/j.yexcr.2015.11.009
Keywords
Extracellular matrix; Breast cancer; Splicing; Microstructure
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Funding
- DOD Breast Cancer Research Program [BC133875]
- L'Oreal USA for women in science program
- CDMRP [793705, BC133875] Funding Source: Federal RePORTER
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The extracellular matrix in the healthy breast has an important tumor suppressive role, whereas the abnormal ECM in tumors can promote aggressiveness, and has been linked to breast cancer relapse, survival and resistance to chemotherapy. This review article gives an overview of the elements of the ECM which have been linked to prognosis of breast cancers, including changes in ECM protein composition, splicing, and microstructure. Published by Elsevier Inc.
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