Journal
EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 241, Issue 10, Pages 1015-1024Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1535370216648022
Keywords
Chitosan; decellularized matrix; amniotic membrane; inflammation; tissue regeneration; biomaterial
Categories
Funding
- NSF Graduate Research Fellowship [DGE 11-44245 FLLW]
- University of Illinois Graduate Dissertation Fellowship
- National Science Foundation [1105300]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of the National Institutes of Health [R03 AR062811]
- Direct For Mathematical & Physical Scien
- Division Of Materials Research [1105300] Funding Source: National Science Foundation
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Tissue regeneration strategies have traditionally relied on designing biomaterials that closely mimic features of the native extracellular matrix (ECM) as a means to potentially promote site-specific cellular behaviors. However, inflammation, while a necessary component of wound healing, can alter processes associated with successful tissue regeneration following an initial injury. These processes can be further magnified by the implantation of a biomaterial within the wound site. In addition to designing biomaterials to satisfy biocompatibility concerns as well as to replicate elements of the composition, structure, and mechanics of native tissue, we propose that ECM analogs should also include features that modulate the inflammatory response. Indeed, strategies that enhance, reduce, or even change the temporal phenotype of inflammatory processes have unique potential as future pro-regenerative analogs. Here, we review derivatives of three natural materials with intrinsic anti-inflammatory properties and discuss their potential to address the challenges of inflammation in tissue engineering and chronic wounds.
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