Journal
ARCHIVES OF GERONTOLOGY AND GERIATRICS
Volume 95, Issue -, Pages -Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.archger.2021.104386
Keywords
Walking speed; Grip strength; Angina pectoris; Myocardial infarction; Older adults
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan [19K07888, 19K11138]
- Grants-in-Aid for Scientific Research [19K07888, 19K11138] Funding Source: KAKEN
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Walking speed was strongly associated with CHD risk in older populations, especially in women. Weak grip strength was related to CHD risk in men, but the association weakened after additional multivariate adjustment.
Background: Physical function is a strong predictor of the adverse outcomes of cardiovascular disease in older populations. However, studies of healthy older people on the prevention of coronary heart disease (CHD) are very limited. Objectives: We prospectively examined the association of walking speed and handgrip strength with CHD in the community-dwelling older populations. Methods: The study cohort in Japan included 1272 older people free from heart disease at the baseline. Physical function was identified based on walking speed and handgrip strength assessment at the survey site. Any new case of CHD was identified based on a self-reported doctor's diagnosis. Cox-proportion hazard models were adjusted for covariate factors to examine the CHD risk. Results: During the 7-year follow-up, 45 new cases of CHD (25 men and 20 women) were documented. Slow walking speed was strongly associated with CHD risk after adjusting for all confounding factors in the total participants and women (hazard ratio (HR)= 2.53, 95%confidence interval (CI), 1.20-5.33, p=0.015, and HR= 4.78, 95% CI,1.07-21.35, p=0.040, respectively), but not in men. Weak grip strength was associated with CHD after age-adjustment (HR= 2.45, 95%CI, 1.03-5.81, p=0.043) only in men. However, after additional multivariate adjustment, the associations were getting weaker.
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