Journal
ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH
Volume 77, Issue 8, Pages 611-620Publisher
ROUTLEDGE JOURNALS, TAYLOR & FRANCIS LTD
DOI: 10.1080/19338244.2021.1980759
Keywords
Metals; metalloids; oxidative stress; biomarkers; rural community
Funding
- Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil [88881.134001/2016-01]
- Brazilian National Council for Scientific and Technological Development (CNPq) [309152/2018-6]
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The study found that exposure to toxic metals and metalloids can alter antioxidant enzyme activities, with barium potentially promoting lipid peroxidation.
We examined the association between exposure to metals, metalloids, and oxidative stress biomarkers among rural community residents in Brazil. Multiple linear regression was used to evaluate associations between serum metal and metalloid concentrations and blood oxidative stress biomarkers, adjusting for sex, age, education, smoking, and alcohol use. After adjustment for covariates, glutathione peroxidase activity (GPx) was inversely and significantly associated with an increase in serum arsenic (As) levels. Positive and significant associations were seen between elevated glutathione reductase (GR) activity and serum cadmium (Cd), barium (Ba), and lead (Pb) concentrations. In addition, we observed a significant increase in malondialdehyde (MDA) levels in association with an increase in Ba levels. These findings suggest that toxic metals and metalloids such as As, Ba, Cd, and Pb alter antioxidant enzyme activities. In addition, Ba seems to promote lipid peroxidation.
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