Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 44, Issue 4, Pages 144-149Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000089
Keywords
fatigue; calcium-sensitivity; muscle; phosphate; acidosis; regulation
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Funding
- American Heart Association [14GRNT20450002]
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Muscle fatigue can result from either the accumulation of metabolic by-products (e.g., P-i and H+) or a decrease in myoplasmic Ca++; however, individually, neither change can explain quantitatively the decrease in force capacity. Therefore, the emerging view is that, by decreasing the sensitivity of myofilaments to calcium, P-i and H+ act synergistically with decreased Ca++ levels to contribute to fatigue.
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