Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 44, Issue 1, Pages 4-11Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000070
Keywords
obesity; prediabetes; type 2 diabetes; insulin resistance; metabolic syndrome; lifestyle modification
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Funding
- Pfizer, Inc.
- NIH [5R56 DK081038]
- ADA [7-04-JF-10]
- ACSM Doctoral Student Foundation [S17100000000113]
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Combining metformin with exercise has been proposed to improve glucose homeostasis. However, we primarily discuss evidence suggesting that metformin and other pharmacological agents/dietary supplements (e.g., statins, resveratol, or antioxidants) may in fact oppose exercise-induced benefits on insulin sensitivity and cardiometabolic health. We explore the novel hypothesis that attenuation of oxidative stress from exercise by these exogenous compounds blunts metabolic adaptation.
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