Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 44, Issue 1, Pages 12-19Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000065
Keywords
endothelial dysfunction; chronic kidney disease; nitric oxide; l-arginine; CAT-1; aerobic exercise
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Funding
- National Institutes of Health [DK080469, GM103446, HL113514]
- ACSM Foundation
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL113514] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R15DK080469] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P20GM103446] Funding Source: NIH RePORTER
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Endothelial dysfunction occurs in chronic kidney disease (CKD) and increases the risk for cardiovascular disease. The mechanisms of endothelial dysfunction seem to evolve throughout kidney disease progression, culminating in reduced l-arginine transport and impaired nitric oxide bioavailability in advanced disease. This review examines the hypothesis that aerobic exercise may reverse endothelial dysfunction by improving endothelial cell l-arginine uptake in CKD.
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