4.7 Article

Minocycline Activity against Unusual Clinically Significant Gram-Negative Pathogens

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 65, Issue 11, Pages -

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01264-21

Keywords

Achromobacter; Aeromonas; minocycline; surveillance

Funding

  1. Melinta Therapeutics, Inc.

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The study analyzed the minocycline susceptibility of various Gram-negative pathogens and found that it can be a useful treatment option, especially for infections caused by Achromobacter and Stenotrophomonas maltophilia which showed the highest susceptibility to minocycline among the species studied.
The minocycline susceptibility of 3,856 isolates including Burkholderia, Achromobacter, Alcaligenes, Aeromonas, and Stenotrophomonas maltophilia from the SENTRY surveillance (2014 to 2019) were analyzed. The susceptibilities of these species (%S) were Achromobacter spp. (n = 411; 92.6%), Burkholderia cepacia species complex (n = 199; 85.9%), Aeromonas spp. (n = 127; 99.2%), Chryseobacterium spp. (n = 59; 94.9%), Alcaligenes faecalis (n = 42; 88.1%), and S. maltophilia (n = 2,287; 99.5%). These data suggest that minocycline is a useful treatment option for infections caused by unusual Gram-negative pathogens.

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