Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 65, Issue 10, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00877-21
Keywords
cefiderocol; Acinetobacter baumannii; susceptibility testing; PER-type beta-lactamase; NDM; PER; beta-lactamase
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Funding
- University of Fribourg, Switzerland
- Swiss National Science Foundation [FNS 310030_1888801]
- NARA
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The study found that PER-like beta-lactamases and NDM-like beta-lactamases significantly contributed to reduced susceptibility to Cefiderocol (FDC). The combination of FDC with avibactam exhibited excellent activity against multidrug-resistant isolates coproducing OXA-23 and PER-type beta-lactamases.
Cefiderocol (FDC) is a recently developed siderophore cephalosporin showing excellent antibacterial activity against Gram-negative bacteria, including Acinetobacter baumannii. By investigating a series of A. baumannii clinical isolates with elevated MICs of FDC, we showed that PER-like beta-lactamases and, to a lesser extent, NDM-like beta-lactamases, significantly contributed to reduced susceptibility to that antibiotic. Interestingly, we showed that combination of FDC with avibactam exhibited excellent activity against all multidrug-resistant isolates coproducing OXA-23 and PER-type beta-lactamases.
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