Conservation of Resistance-Nodulation-Cell Division Efflux Pump-Mediated Antibiotic Resistance in Burkholderia cepacia Complex and Burkholderia pseudomallei Complex Species

Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkhoideria. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.

Automated summary

Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species are typically multidrug resistant, with dominant resistance mechanisms mediated by efflux pumps of the RND family. Comparative bioinformatic and functional studies suggest that RND pump-based resistance mechanisms are conserved in Burkholderia, providing a basis for adopting a uniform RND efflux pump nomenclature.