Contribution of Interleukin-12A Genotypes to Breast Cancer Risk

Background/Aim: Breast cancer incidence is highest among women worldwide, and practical markers for personalized therapeutic strategies are few. Interleukin-12 (IL-12) is a cytokine that is reported to be significantly lower in healthy controls than breast cancer cases, however, its genotypic contribution to carcinogenesis has never been revealed in breast cancer. We examined whether IL-12A rs568408 and rs2243115 genotypes contribute to elevated breast cancer risk and summarized related literature among other cancers. Materials and Methods: IL-12A genotypic profiles were determined among 1,232 breast cancer cases and 1,232 healthy controls via polymerase chain reaction- restriction fragment length polymorphism methodology. Results: The variant genotypes of IL-12A rs568408 and rs2243115 were not found to be significantly associated with elevated breast cancer risk (both p>0.05). Conclusion: IL 12A rs568408 and rs2243115 genotypes may not serve as good predictors of breast cancer risk.

Automated summary

The variant genotypes of IL-12A rs568408 and rs2243115 were not found to be significantly associated with elevated breast cancer risk, indicating that these genotypes may not be good predictors for breast cancer risk.