Related references
Note: Only part of the references are listed.Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells
Chandrani Fouzder et al.
TOXICOLOGY IN VITRO (2021)
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis
Yun Pyo Kang et al.
CELL METABOLISM (2021)
ATDC binds to KEAP1 to drive NRF2-mediated tumorigenesis and chemoresistance in pancreatic cancer
Vinee Purohit et al.
GENES & DEVELOPMENT (2021)
The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2
Chunjie Meng et al.
ONCOGENE (2021)
NRF2-Dependent Bioactivation of Mitomycin C as a Novel Strategy To Target KEAP1-NRF2 Pathway Activation in Human Cancer
Liam Baird et al.
MOLECULAR AND CELLULAR BIOLOGY (2021)
Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone
Laura Torrente et al.
REDOX BIOLOGY (2020)
Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma
Kewen Hu et al.
JOURNAL OF CLINICAL INVESTIGATION (2020)
A small molecule G6PD inhibitor reveals immune dependence on pentose phosphate pathway
Jonathan M. Ghergurovich et al.
NATURE CHEMICAL BIOLOGY (2020)
Microenvironmental Activation of Nrf2 Restricts the Progression of Nrf2-Activated Malignant Tumors
Makiko Hayashi et al.
CANCER RESEARCH (2020)
Gain-of-function genetic screen of the kinome reveals BRSK2 as an inhibitor of the NRF2 transcription factor
Tigist Y. Tamir et al.
JOURNAL OF CELL SCIENCE (2020)
KEAP1, a cysteine-based sensor and a drug target for the prevention and treatment of chronic disease
Sharadha Dayalan Naidu et al.
OPEN BIOLOGY (2020)
Geldanamycin-Derived HSP90 Inhibitors Are Synthetic Lethal with NRF2
Liam Baird et al.
MOLECULAR AND CELLULAR BIOLOGY (2020)
KEAP1/NFE2L2 Mutations Predict Lung Cancer Radiation Resistance That Can Be Targeted by Glutaminase Inhibition
Michael S. Binkley et al.
CANCER DISCOVERY (2020)
PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor
Tigist Y. Tamir et al.
SCIENTIFIC REPORTS (2020)
Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer
Janine M. DeBlasi et al.
CANCERS (2020)
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation
Sarmistha Saha et al.
MOLECULES (2020)
NRF2 Activation in Cancer: From DNA to Protein
Erica W. Cloer et al.
CANCER RESEARCH (2019)
Cysteine dioxygenase 1 is a metabolic liability for non-small cell lung cancer
Yun Pyo Kang et al.
ELIFE (2019)
Mutations in the KEAP1-NFE2L2 Pathway Define a Molecular Subset of Rapidly Progressing Lung Adenocarcinoma
Frauke Goeman et al.
JOURNAL OF THORACIC ONCOLOGY (2019)
The Oncogenic Action of NRF2 Depends on De-glycation by Fructosamine-3-Kinase
Viraj R. Sanghvi et al.
CELL (2019)
Cancer Cells Upregulate NRF2 Signaling to Adapt to Autophagy Inhibition
Christina G. Towers et al.
DEVELOPMENTAL CELL (2019)
Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma
Sarah A. Best et al.
NATURE COMMUNICATIONS (2019)
Therapeutic targeting of the NRF2 and KEAP 1 partnership in chronic diseases
Antonio Cuadrado et al.
NATURE REVIEWS DRUG DISCOVERY (2019)
Erastin, a ferroptosis-inducing agent, sensitized cancer cells to X-ray irradiation via glutathione starvation in vitro and in vivo
Yuki Shibata et al.
PLOS ONE (2019)
Gene-expression signature regulated by the KEAP1-NRF2-CUL3 axis is associated with a poor prognosis in head and neck squamous cell cancer
Akhileshwar Namani et al.
BMC CANCER (2018)
NRF2 and the Hallmarks of Cancer
Montserrat Rojo de la Vega et al.
CANCER CELL (2018)
Oncogenic Signaling Pathways in The Cancer Genome Atlas
Francisco Sanchez-Vega et al.
CELL (2018)
Synergy between the KEAP1/NRF2 and PI3K Pathways Drives Non-Small-Cell Lung Cancer with an Altered Immune Microenvironment
Sarah A. Best et al.
CELL METABOLISM (2018)
Pharmacological blockade of ASCT2-dependent glutamine transport leads to antitumor efficacy in preclinical models
Michael L. Schulte et al.
NATURE MEDICINE (2018)
xCT (SLC7A11)-mediated metabolic reprogramming promotes non-small cell lung cancer progression
Xiangming Ji et al.
ONCOGENE (2018)
The ferroptosis inducer erastin irreversibly inhibits system xc- and synergizes with cisplatin to increase cisplatin's cytotoxicity in cancer cells
Mami Sato et al.
SCIENTIFIC REPORTS (2018)
Inhibition of Glucose-6-Phosphate Dehydrogenase Reverses Cisplatin Resistance in Lung Cancer Cells via the Redox System
Weipeng Hong et al.
FRONTIERS IN PHARMACOLOGY (2018)
Activation of p62/SQSTM1-Keap1-Nuclear Factor erythroid 2-Related Factor 2 Pathway in Cancer
Yoshinobu Ichimura et al.
FRONTIERS IN ONCOLOGY (2018)
A catalogue of somatic NRF2 gain-of-function mutations in cancer
Michael John Kerins et al.
SCIENTIFIC REPORTS (2018)
Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells
Hitoshi Endo et al.
SCIENTIFIC REPORTS (2018)
The Regulation of NRF2 by Nutrient-Responsive Signaling and Its Role in Anabolic Cancer Metabolism
Sae Bom Lee et al.
ANTIOXIDANTS & REDOX SIGNALING (2018)
The Roles of NRF2 in Modulating Cellular Iron Homeostasis
Michael John Kerins et al.
ANTIOXIDANTS & REDOX SIGNALING (2018)
Phase 1 study of ARQ 761, a β-lapachone analogue that promotes NQO1-mediated programmed cancer cell necrosis
David E. Gerber et al.
BRITISH JOURNAL OF CANCER (2018)
A metabolite-derived protein modification integrates glycolysis with KEAP1-NRF2 signalling
Michael J. Bollong et al.
NATURE (2018)
Systemic depletion of L-cyst(e)ine with cyst(e)inase increases reactive oxygen species and suppresses tumor growth
Shiro L. Cramer et al.
NATURE MEDICINE (2017)
Halofuginone enhances the chemo-sensitivity of cancer cells by suppressing NRF2 accumulation
Kouhei Tsuchida et al.
FREE RADICAL BIOLOGY AND MEDICINE (2017)
Using a novel NQO1 bioactivatable drug, beta-lapachone (ARQ761), to enhance chemotherapeutic effects by metabolic modulation in pancreatic cancer
Muhammad Shaalan Beg et al.
JOURNAL OF SURGICAL ONCOLOGY (2017)
Keap1 loss promotes Kras-driven lung cancer and results in dependence on glutaminolysis
Rodrigo Romero et al.
NATURE MEDICINE (2017)
β-lapachone suppresses tumour progression by inhibiting epithelial-to-mesenchymal transition in NQO1-positive breast cancers
Yang Yang et al.
SCIENTIFIC REPORTS (2017)
WDR23 regulates NRF2 independently of KEAP1
Jacqueline Y. Lo et al.
PLOS GENETICS (2017)
Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer
Volkan I. Sayin et al.
ELIFE (2017)
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Marta Pajares et al.
REDOX BIOLOGY (2017)
Keap1, the cysteine-based mammalian intracellular sensor for electrophiles and oxidants
Albena T. Dinkova-Kostova et al.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS (2017)
Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
Xiaofang Sun et al.
HEPATOLOGY (2016)
Application of Mass Spectrometry Profiling to Establish Brusatol as an Inhibitor of Global Protein Synthesis
Steffan Vartanian et al.
MOLECULAR & CELLULAR PROTEOMICS (2016)
Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
Anju Singh et al.
ACS CHEMICAL BIOLOGY (2016)
Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes
Marta Pajares et al.
AUTOPHAGY (2016)
2-Amino-4-bis(aryloxybenzyl)aminobutanoic acids: A novel scaffold for inhibition of ASCT2-mediated glutamine transport
Michael L. Schulte et al.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS (2016)
p62, Upregulated during Preneoplasia, Induces Hepatocellular Carcinogenesis by Maintaining Survival of Stressed HCC-Initiating Cells
Atsushi Umemura et al.
CANCER CELL (2016)
Leveraging an NQO1 Bioactivatable Drug for Tumor-Selective Use of Poly(ADP-ribose) Polymerase Inhibitors
Xiumei Huang et al.
CANCER CELL (2016)
NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth
Hironori Satoh et al.
CANCER RESEARCH (2016)
AMPK Facilitates Nuclear Accumulation of Nrf2 by Phosphorylating at Serine 550
Min Sung Joo et al.
MOLECULAR AND CELLULAR BIOLOGY (2016)
Sulforaphane Preconditioning Sensitizes Human Colon Cancer Cells towards the Bioreductive Anticancer Prodrug PR-104A
Melanie M. Erzinger et al.
PLOS ONE (2016)
p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming
Tetsuya Saito et al.
NATURE COMMUNICATIONS (2016)
Recurrent Loss of NFE2L2 Exon 2 Is a Mechanism for Nrf2 Pathway Activation in Human Cancers
Leonard D. Goldstein et al.
CELL REPORTS (2016)
NAD(P)H: Quinone Oxidoreductase-1 Expression Sensitizes Malignant Melanoma Cells to the HSP90 Inhibitor 17-AAG
Shuya Kasai et al.
PLOS ONE (2016)
A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer
Michael J. Bollong et al.
ACS CHEMICAL BIOLOGY (2015)
Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of beta-TrCP and GSK-3
John D. Hayes et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2015)
NQO1 protein expression predicts poor prognosis of non-small cell lung cancers
Zhenling Li et al.
BMC CANCER (2015)
Brusatol provokes a rapid and transient inhibition of Nrf2 signaling and sensitizes mammalian cells to chemical toxicity-implications for therapeutic targeting of Nrf2
Adedamola Olayanju et al.
FREE RADICAL BIOLOGY AND MEDICINE (2015)
Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP
Antonio Cuadrado
FREE RADICAL BIOLOGY AND MEDICINE (2015)
NRF2 regulates serine biosynthesis in non-small cell lung cancer
Gina M. DeNicola et al.
NATURE GENETICS (2015)
The PTEN/NRF2 Axis Promotes Human Carcinogenesis
Ana I. Rojo et al.
ANTIOXIDANTS & REDOX SIGNALING (2014)
NQO1 overexpression is associated with poor prognosis in squamous cell carcinoma of the uterine cervix
Yue Ma et al.
BMC CANCER (2014)
Oncogenic KRAS Confers Chemoresistance by Upregulating NRF2
Shasha Tao et al.
CANCER RESEARCH (2014)
Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
Tongde Wu et al.
GENES & DEVELOPMENT (2014)
Clinical implications of high NQO1 expression in breast cancers
Yang Yang et al.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH (2014)
The Nrf2 regulatory network provides an interface between redox and intermediary metabolism
John D. Hayes et al.
TRENDS IN BIOCHEMICAL SCIENCES (2014)
Integrative Radiogenomic Profiling of Squamous Cell Lung Cancer
Mohamed E. Abazeed et al.
CANCER RESEARCH (2013)
Nrf2 is a potential therapeutic target in radioresistance in human cancer
Suna Zhou et al.
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY (2013)
PTEN modulators: a patent review
Chandra S. Boosani et al.
EXPERT OPINION ON THERAPEUTIC PATENTS (2013)
Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy
Yoshinobu Ichimura et al.
MOLECULAR CELL (2013)
Inhibition of the Nrf2 transcription factor by the alkaloid trigonelline renders pancreatic cancer cells more susceptible to apoptosis through decreased proteasomal gene expression and proteasome activity
A. Arlt et al.
ONCOGENE (2013)
Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
S. Chowdhry et al.
ONCOGENE (2013)
Glucose availability is a decisive factor for Nrf2-mediated gene expression
Elke H. Heiss et al.
REDOX BIOLOGY (2013)
NAD(P)H:quinone oxidoreductase 1 (NQO1) in the sensitivity and resistance to antitumor quinones
David Siegel et al.
BIOCHEMICAL PHARMACOLOGY (2012)
Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
Yoichiro Mitsuishi et al.
CANCER CELL (2012)
An NQO1 Substrate with Potent Antitumor Activity That Selectively Kills by PARP1-Induced Programmed Necrosis
Xiumei Huang et al.
CANCER RESEARCH (2012)
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Scott J. Dixon et al.
CELL (2012)
TBK-1 Promotes Autophagy-Mediated Antimicrobial Defense by Controlling Autophagosome Maturation
Manohar Pilli et al.
IMMUNITY (2012)
Comprehensive genomic characterization of squamous cell lung cancers
Peter S. Hammerman et al.
NATURE (2012)
Nrf2: control of sensitivity to carcinogens
Stephen L. Slocum et al.
ARCHIVES OF TOXICOLOGY (2011)
Succination of Keap1 and Activation of Nrf2-Dependent Antioxidant Pathways in FH-Deficient Papillary Renal Cell Carcinoma Type 2
Lisa Kinch et al.
CANCER CELL (2011)
Renal Cyst Formation in Fh1-Deficient Mice Is Independent of the Hif/Phd Pathway: Roles for Fumarate in KEAP1 Succination and Nrf2 Signaling
Julie Adam et al.
CANCER CELL (2011)
Disruption of xCT inhibits cell growth via the ROS/autophagy pathway in hepatocellular carcinoma
Weijie Guo et al.
CANCER LETTERS (2011)
NRF2 Blockade Suppresses Colon Tumor Angiogenesis by Inhibiting Hypoxia-Induced Activation of HIF-1α
Tae-Hyoung Kim et al.
CANCER RESEARCH (2011)
Persistent activation of Nrf2 through p62 in hepatocellular carcinoma cells
Yoshihiro Inami et al.
JOURNAL OF CELL BIOLOGY (2011)
Coffee constituents as modulators of Nrf2 nuclear translocation and ARE (EpRE)-dependent gene expression
Ute Boettler et al.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY (2011)
p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway
Angeles Duran et al.
MOLECULAR CELL (2011)
Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins
Gen Matsumoto et al.
MOLECULAR CELL (2011)
Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
Gina M. De Nicola et al.
NATURE (2011)
Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
Dongmei Ren et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
NRF2 Mutation Confers Malignant Potential and Resistance to Chemoradiation Therapy in Advanced Esophageal Squamous Cancer
Tatsuhiro Shibata et al.
NEOPLASIA (2011)
The Bioreductive Prodrug PR-104A Is Activated under Aerobic Conditions by Human Aldo-Keto Reductase 1C3
Christopher P. Guise et al.
CANCER RESEARCH (2010)
Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
Hironori Satoh et al.
CARCINOGENESIS (2010)
Nrf2 and Keap1 Abnormalities in Non-Small Cell Lung Carcinoma and Association with Clinicopathologic Features
Luisa M. Solis et al.
CLINICAL CANCER RESEARCH (2010)
Knockout of the transcription factor NRF2 disrupts spermatogenesis in an age-dependent manner
Brooke N. Nakamura et al.
FREE RADICAL BIOLOGY AND MEDICINE (2010)
p62/SQSTM1 Is a Target Gene for Transcription Factor NRF2 and Creates a Positive Feedback Loop by Inducing Antioxidant Response Element-driven Gene Transcription
Ashish Jain et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
Weimin Chen et al.
MOLECULAR CELL (2009)
RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy
Anju Singh et al.
CANCER RESEARCH (2008)
Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
Xiao-Jun Wang et al.
CARCINOGENESIS (2008)
Enzymatic reduction and glutathione conjugation of benzoquinone ansamycin heat shock protein 90 inhibitors: Relevance for toxicity and mechanism of action
Wenchang Guo et al.
DRUG METABOLISM AND DISPOSITION (2008)
Oridonin confers protection against arsenic-induced toxicity through activation of the Nrf2-mediated defensive response
Yu Du et al.
ENVIRONMENTAL HEALTH PERSPECTIVES (2008)
NQO1 expression in pancreatic cancer and its potential use as a biomarker
Nida S. Awadallah et al.
APPLIED IMMUNOHISTOCHEMISTRY & MOLECULAR MORPHOLOGY (2008)
Identification of human reductases that activate the dinitrobenzamide mustard prodrug PR-104A:: A role for NADPH:cytochrome P450 oxidoreductase under hypoxia
Chris P. Guise et al.
BIOCHEMICAL PHARMACOLOGY (2007)
An NQO1-and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by β-lapachone
Erik A. Bey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Increased protein glycation in fructosamine 3-kinase-deficient mice
Maria Veiga-Da-Cunha et al.
BIOCHEMICAL JOURNAL (2006)
Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer
Anju Singh et al.
PLOS MEDICINE (2006)
Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2
Qiang Ma et al.
AMERICAN JOURNAL OF PATHOLOGY (2006)
Keap1 recruits Neh2 through binding to ETGE and DLG motifs: Characterization of the two-site molecular recognition model
KI Tong et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Formation of 17-allylamino-demethoxygeldanamycin (17-AAG) hydroquinone by NAD(P)H:quinone oxidoreductase 1:: Role of 17-AAG hydroquinone in heat shock protein 90 inhibition.
WC Guo et al.
CANCER RESEARCH (2005)
Antitumor activity of bruceantin: An old drug with new promise
M Cuendet et al.
JOURNAL OF NATURAL PRODUCTS (2004)
Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex
DD Zhang et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Phosphorylation of Nrf2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrf2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression
DA Bloom et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Nrf2 is a direct PERK substrate and effector of PERK-dependent cell survival
SB Cullinan et al.
MOLECULAR AND CELLULAR BIOLOGY (2003)
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
M McMahon et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Electrophile response element-mediated induction of the cystine/glutamate exchange transporter gene expression
H Sasaki et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the xc- cystine transporter:: a new action for an old drug
PW Gout et al.
LEUKEMIA (2001)
Immunodetection of NAD(P)H:quinone oxidoreductase 1 (NQO1) in human tissues
D Sieger et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Persuasive evidence that quinone reductase type 1 (DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen
LT Dinkova-Kostova et al.
FREE RADICAL BIOLOGY AND MEDICINE (2000)
Share Paper
