Biology and Models of the Blood-Brain Barrier

The blood-brain barrier (BBB) is one of the most selective endothelial barriers. An understanding of its cellular, morphological, and biological properties in health and disease is necessary to develop therapeutics that can be transported from blood to brain. In vivo models have provided some insight into these features and transport mechanisms adopted at the brain, yet they have failed as a robust platform for the translation of results into clinical outcomes. In this article, we provide a general overview of major BBB features and describe various models that have been designed to replicate this barrier and neurological pathologies linked with the BBB. We propose several key parameters and design characteristics that can be employed to engineer physiologically relevant models of the blood-brain interface and highlight the need for a consensus in the measurement of fundamental properties of this barrier.

Automated summary

The article provides a general overview of the major features of the blood-brain barrier and describes various models designed to replicate this barrier and associated neurological pathologies. It emphasizes the need for consensus in measuring the fundamental properties of the barrier and proposes key parameters and design characteristics for creating physiologically relevant models of the blood-brain interface.