4.3 Article

Effect of Yi Gong San Decoction on Iron Homeostasis in a Mouse Model of Acute Inflammation

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Publisher

HINDAWI LTD
DOI: 10.1155/2016/2696480

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Funding

  1. National Natural Sciences Foundation of China [81102569, 81500676]
  2. Science & Technology Commission of Shanghai Municipality [13ZR1440000]
  3. Shanghai Municipal Commission of Health and Family Planning [201440587]

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We investigated the effect of Yi Gong San (YGS) decoction on iron homeostasis and the possible underlying mechanisms in a mouse model of acute inflammation in this study. Our findings suggest that YGS regulates iron homeostasis by downregulating the level of HAMP mRNA, which may depend on regulation of the IL-6/STAT3 or BMP/HJV/SMAD pathway during acute inflammation.

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